6RU8

Crystal structure of Casein Kinase I delta (CK1d) in complex with triple phosphorylated p63 PAD3P peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue ADP A 301

Chain	Residue
A	GLY16
A	GLU83
A	LEU85
A	ILE148
A	ASP149
A	HOH407
A	HOH423
A	HOH461
A	HOH464
A	HOH481
A	SER17
A	GLY18
A	ILE23
A	ALA36
A	LYS38
A	GLU52
A	TYR56
A	MET82

---

site_id	AC2
Number of Residues	8
Details	binding site for residue EDO A 302

Chain	Residue
A	ILE15
A	LEU85
A	GLY86
A	HOH464
D	ARG10
D	THR27
D	GLU34
D	EDO304

---

site_id	AC3
Number of Residues	7
Details	binding site for residue EDO A 303

Chain	Residue
A	PRO87
A	MET136
A	GLY142
A	TRP290
A	HOH422
D	ILE29
D	GLY32

---

site_id	AC4
Number of Residues	6
Details	binding site for residue EDO A 304

Chain	Residue
A	ILE29
A	GLY32
D	PRO87
D	MET136
D	GLY137
D	TRP290

---

site_id	AC5
Number of Residues	4
Details	binding site for residue EDO A 305

Chain	Residue
A	ARG157
A	ARG192
A	HOH404
A	HOH460

---

site_id	AC6
Number of Residues	3
Details	binding site for residue EDO A 306

Chain	Residue
A	ARG127
A	LYS154
A	LYS171

---

site_id	AC7
Number of Residues	5
Details	binding site for residue NA A 307

Chain	Residue
A	ASN143
A	TYR286
A	ASN291
A	HOH422
A	HOH523

---

site_id	AC8
Number of Residues	5
Details	binding site for residue SO4 A 308

Chain	Residue
A	ARG279
A	HOH443
C	SER267
C	ARG270
C	ARG274

---

site_id	AC9
Number of Residues	17
Details	binding site for residue ADP B 301

Chain	Residue
B	GLY16
B	SER17
B	GLY18
B	ILE23
B	ALA36
B	LYS38
B	GLU52
B	TYR56
B	MET82
B	GLU83
B	LEU85
B	ILE148
B	ASP149
B	HOH434
B	HOH456
B	HOH467
B	HOH471

---

site_id	AD1
Number of Residues	6
Details	binding site for residue EDO B 302

Chain	Residue
B	GLU117
B	HIS120
B	SER121
B	TYR156
B	ARG192
B	TYR266

---

site_id	AD2
Number of Residues	3
Details	binding site for residue EDO B 303

Chain	Residue
B	LYS171
B	ASN172
B	SO4308

---

site_id	AD3
Number of Residues	6
Details	binding site for residue EDO B 304

Chain	Residue
B	ASN183
B	LEU186
B	ARG256
B	HOH420
C	MET233
C	HOH488

---

site_id	AD4
Number of Residues	6
Details	binding site for residue EDO B 305

Chain	Residue
B	ASN253
B	SER257
B	HOH444
C	ASN253
C	ARG256
C	SER257

---

site_id	AD5
Number of Residues	4
Details	binding site for residue NA B 306

Chain	Residue
B	ASN143
B	TYR286
B	ASN291
B	HOH528

---

site_id	AD6
Number of Residues	5
Details	binding site for residue SO4 B 307

Chain	Residue
B	HOH452
D	SER267
D	ARG270
D	ARG274
B	ARG279

---

site_id	AD7
Number of Residues	4
Details	binding site for residue SO4 B 308

Chain	Residue
B	ARG127
B	LYS154
B	LYS171
B	EDO303

---

site_id	AD8
Number of Residues	17
Details	binding site for residue ADP C 301

Chain	Residue
C	GLY16
C	SER17
C	GLY18
C	ILE23
C	ALA36
C	LYS38
C	GLU52
C	TYR56
C	MET82
C	GLU83
C	LEU85
C	LEU135
C	ILE148
C	ASP149
C	HOH416
C	HOH421
C	HOH453

---

site_id	AD9
Number of Residues	6
Details	binding site for residue EDO C 302

Chain	Residue
C	ARG10
C	GLY12
C	LEU25
C	THR27
C	GLU34
C	EDO303

---

site_id	AE1
Number of Residues	7
Details	binding site for residue EDO C 303

Chain	Residue
B	LEU85
B	GLY86
B	HOH429
C	ARG10
C	THR27
C	GLU34
C	EDO302

---

site_id	AE2
Number of Residues	6
Details	binding site for residue EDO C 304

Chain	Residue
C	GLY21
C	ASP22
C	TYR24
C	LEU39
C	CYS41
C	HOH451

---

site_id	AE3
Number of Residues	4
Details	binding site for residue EDO C 305

Chain	Residue
B	LEU25
B	GLU34
C	LEU85
C	GLY86

---

site_id	AE4
Number of Residues	6
Details	binding site for residue EDO C 306

Chain	Residue
B	PRO87
B	MET136
B	GLY142
B	TRP290
C	ILE29
C	GLY32

---

site_id	AE5
Number of Residues	7
Details	binding site for residue EDO C 307

Chain	Residue
B	ILE29
B	GLY32
C	PRO87
C	MET136
C	GLY137
C	TRP290
C	HOH418

---

site_id	AE6
Number of Residues	19
Details	binding site for residue ADP D 301

Chain	Residue
D	SER17
D	GLY18
D	ILE23
D	ALA36
D	LYS38
D	GLU52
D	TYR56
D	MET82
D	GLU83
D	LEU85
D	LEU135
D	ILE148
D	ASP149
D	HOH401
D	HOH435
D	HOH441
D	HOH451
D	HOH456
D	HOH472

---

site_id	AE7
Number of Residues	5
Details	binding site for residue EDO D 302

Chain	Residue
A	SER257
D	PRO236
D	ILE237
D	GLU238
D	ASN253

---

site_id	AE8
Number of Residues	5
Details	binding site for residue EDO D 303

Chain	Residue
A	ASN253
A	SER257
A	HOH437
D	ASN253
D	SER257

---

site_id	AE9
Number of Residues	7
Details	binding site for residue EDO D 304

Chain	Residue
A	EDO302
D	ARG10
D	GLY12
D	LEU25
D	GLY26
D	THR27
D	GLU34

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGDIYlGtdiaagee..........VAIK

Chain	Residue	Details
A	ILE15-LYS38

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. FiHrDVKpdNFLM

Chain	Residue	Details
A	PHE124-MET136

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	804
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---