6RO1

X-ray crystal structure of the MTR4 NVL complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000176	cellular_component	nuclear exosome (RNase complex)
A	0000178	cellular_component	exosome (RNase complex)
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0000460	biological_process	maturation of 5.8S rRNA
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0003724	molecular_function	RNA helicase activity
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005681	cellular_component	spliceosomal complex
A	0005730	cellular_component	nucleolus
A	0006364	biological_process	rRNA processing
A	0006397	biological_process	mRNA processing
A	0006401	biological_process	RNA catabolic process
A	0006974	biological_process	DNA damage response
A	0008380	biological_process	RNA splicing
A	0016076	biological_process	snRNA catabolic process
A	0016607	cellular_component	nuclear speck
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0031499	cellular_component	TRAMP complex
A	0071013	cellular_component	catalytic step 2 spliceosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue SO4 A 1101

Chain	Residue
A	HIS456
A	GLY457
A	THR482
A	THR484

---

site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 A 1102

Chain	Residue
A	SER395
A	LYS396
A	LYS397

---

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 1103

Chain	Residue
A	ARG854
A	THR566
A	TYR567

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 1104

Chain	Residue
A	LYS661
A	TRP671
A	GLY773
A	ILE774

---

site_id	AC5
Number of Residues	2
Details	binding site for residue SO4 A 1105

Chain	Residue
A	ILE191
A	LYS192

---

site_id	AC6
Number of Residues	10
Details	binding site for residue ADP A 1106

Chain	Residue
A	PHE138
A	ILE139
A	GLN144
A	THR163
A	SER164
A	ALA165
A	GLY166
A	LYS167
A	THR168
A	ARG527

---

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 B 301

Chain	Residue
A	GLN655
A	ARG743
B	SER180

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9DBY8

Chain	Residue	Details
B	SER191

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692

Chain	Residue	Details
B	SER211

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
B	SER215
A	GLY166
A	LYS167
A	THR168

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
B	LYS208

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS358
A	LYS723

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS684

---