6RNG
Dipeptide Gly-Pro binds to a glycolytic enzyme fructose bisphosphate aldolase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003729 | molecular_function | mRNA binding |
| A | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| A | 0005507 | molecular_function | copper ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006096 | biological_process | glycolytic process |
| A | 0009506 | cellular_component | plasmodesma |
| A | 0016829 | molecular_function | lyase activity |
| A | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| A | 0031930 | biological_process | mitochondria-nucleus signaling pathway |
| A | 0071456 | biological_process | cellular response to hypoxia |
| A | 1901149 | molecular_function | salicylic acid binding |
| B | 0003729 | molecular_function | mRNA binding |
| B | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| B | 0005507 | molecular_function | copper ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006094 | biological_process | gluconeogenesis |
| B | 0006096 | biological_process | glycolytic process |
| B | 0009506 | cellular_component | plasmodesma |
| B | 0016829 | molecular_function | lyase activity |
| B | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| B | 0031930 | biological_process | mitochondria-nucleus signaling pathway |
| B | 0071456 | biological_process | cellular response to hypoxia |
| B | 1901149 | molecular_function | salicylic acid binding |
| F | 0003729 | molecular_function | mRNA binding |
| F | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| F | 0005507 | molecular_function | copper ion binding |
| F | 0005515 | molecular_function | protein binding |
| F | 0005634 | cellular_component | nucleus |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0005783 | cellular_component | endoplasmic reticulum |
| F | 0005829 | cellular_component | cytosol |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0006094 | biological_process | gluconeogenesis |
| F | 0006096 | biological_process | glycolytic process |
| F | 0009506 | cellular_component | plasmodesma |
| F | 0016829 | molecular_function | lyase activity |
| F | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| F | 0031930 | biological_process | mitochondria-nucleus signaling pathway |
| F | 0071456 | biological_process | cellular response to hypoxia |
| F | 1901149 | molecular_function | salicylic acid binding |
| G | 0003729 | molecular_function | mRNA binding |
| G | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| G | 0005507 | molecular_function | copper ion binding |
| G | 0005515 | molecular_function | protein binding |
| G | 0005634 | cellular_component | nucleus |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005739 | cellular_component | mitochondrion |
| G | 0005783 | cellular_component | endoplasmic reticulum |
| G | 0005829 | cellular_component | cytosol |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0006094 | biological_process | gluconeogenesis |
| G | 0006096 | biological_process | glycolytic process |
| G | 0009506 | cellular_component | plasmodesma |
| G | 0016829 | molecular_function | lyase activity |
| G | 0030388 | biological_process | fructose 1,6-bisphosphate metabolic process |
| G | 0031930 | biological_process | mitochondria-nucleus signaling pathway |
| G | 0071456 | biological_process | cellular response to hypoxia |
| G | 1901149 | molecular_function | salicylic acid binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 401 |
| Chain | Residue |
| A | GLN156 |
| A | ARG203 |
| A | LYS210 |
| A | ASP214 |
| A | HOH548 |
| B | GLN156 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 401 |
| Chain | Residue |
| B | ILE159 |
| B | ARG203 |
| B | ALA207 |
| B | LYS210 |
| B | HOH501 |
| A | GLN156 |
| A | HOH526 |
| B | GLN156 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 B 402 |
| Chain | Residue |
| B | ARG253 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 403 |
| Chain | Residue |
| B | SER32 |
| B | THR35 |
| B | LYS103 |
| B | HOH507 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 404 |
| Chain | Residue |
| A | LYS288 |
| A | HOH513 |
| A | HOH540 |
| B | LYS285 |
| B | HOH521 |
| B | HOH534 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 405 |
| Chain | Residue |
| B | GLU11 |
| B | LYS94 |
| B | ARG139 |
| B | HOH522 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 406 |
| Chain | Residue |
| A | GLN156 |
| A | ARG203 |
| B | GLN156 |
| B | ARG203 |
| B | HOH516 |
| B | HOH549 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue GLY B 407 |
| Chain | Residue |
| B | GLY267 |
| B | ARG298 |
| B | PRO408 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue PRO B 408 |
| Chain | Residue |
| B | LEU265 |
| B | SER266 |
| B | GLY267 |
| B | ARG298 |
| B | GLY407 |
| B | HOH548 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 F 401 |
| Chain | Residue |
| F | GLN156 |
| F | ILE159 |
| F | ARG203 |
| F | ALA207 |
| F | LYS210 |
| F | ASP214 |
| F | HOH551 |
| G | GLN156 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 F 402 |
| Chain | Residue |
| F | ASP30 |
| F | SER32 |
| F | THR35 |
| F | LYS103 |
| F | HOH520 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 G 401 |
| Chain | Residue |
| F | GLN156 |
| G | GLN156 |
| G | ILE159 |
| G | ARG203 |
| G | ALA207 |
| G | LYS210 |
| G | ASP214 |
| G | HOH512 |
| G | HOH560 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 G 402 |
| Chain | Residue |
| G | ASP30 |
| G | GLU31 |
| G | SER32 |
| G | THR35 |
| G | LYS103 |
| G | HOH537 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 G 403 |
| Chain | Residue |
| F | LYS288 |
| F | HOH529 |
| G | LYS285 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 G 404 |
| Chain | Residue |
| F | LYS327 |
| G | GLU11 |
| G | LYS94 |
| G | ARG139 |
| G | HOH572 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue GLY G 405 |
| Chain | Residue |
| G | SER266 |
| G | GLY267 |
| G | ARG298 |
| G | PRO406 |
| G | HOH556 |
| site_id | AD8 |
| Number of Residues | 8 |
| Details | binding site for residue PRO G 406 |
| Chain | Residue |
| G | ARG39 |
| G | LYS225 |
| G | SER266 |
| G | SER295 |
| G | GLY297 |
| G | ARG298 |
| G | GLY405 |
| G | HOH552 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue GLY G 407 |
| Chain | Residue |
| F | GLY64 |
| F | CYS68 |
| F | LYS327 |
| G | PRO408 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for residue PRO G 408 |
| Chain | Residue |
| G | HOH546 |
| G | ASN15 |
| G | GLY407 |
Functional Information from PROSITE/UniProt
| site_id | PS00158 |
| Number of Residues | 11 |
| Details | ALDOLASE_CLASS_I Fructose-bisphosphate aldolase class-I active site. VlLEGtLLKPN |
| Chain | Residue | Details |
| A | VAL217-ASN227 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P00883 |
| Chain | Residue | Details |
| A | GLU183 | |
| B | GLU183 | |
| F | GLU183 | |
| G | GLU183 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Schiff-base intermediate with dihydroxyacetone-P => ECO:0000250|UniProtKB:P00883 |
| Chain | Residue | Details |
| A | LYS225 | |
| B | LYS225 | |
| F | LYS225 | |
| G | LYS225 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P00883 |
| Chain | Residue | Details |
| A | ARG39 | |
| G | ARG39 | |
| G | SER266 | |
| G | ARG298 | |
| A | SER266 | |
| A | ARG298 | |
| B | ARG39 | |
| B | SER266 | |
| B | ARG298 | |
| F | ARG39 | |
| F | SER266 | |
| F | ARG298 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate => ECO:0000250|UniProtKB:P00883 |
| Chain | Residue | Details |
| A | TYR358 | |
| B | TYR358 | |
| F | TYR358 | |
| G | TYR358 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: N-acetylserine => ECO:0000250|UniProtKB:Q9LF98 |
| Chain | Residue | Details |
| A | SER2 | |
| B | SER2 | |
| F | SER2 | |
| G | SER2 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: S-glutathionyl cysteine; transient => ECO:0000269|PubMed:21782461 |
| Chain | Residue | Details |
| A | CYS68 | |
| B | CYS68 | |
| F | CYS68 | |
| G | CYS68 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: S-nitrosocysteine; transient; alternate => ECO:0000269|PubMed:21782461 |
| Chain | Residue | Details |
| A | CYS173 | |
| B | CYS173 | |
| F | CYS173 | |
| G | CYS173 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9LF98 |
| Chain | Residue | Details |
| A | SER350 | |
| B | SER350 | |
| F | SER350 | |
| G | SER350 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: N6,N6,N6-trimethyllysine => ECO:0000250|UniProtKB:Q9SJU4 |
| Chain | Residue | Details |
| A | LYS354 | |
| B | LYS354 | |
| F | LYS354 | |
| G | LYS354 |
