6RLB

Structure of the dynein-2 complex; tail domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003824	molecular_function	catalytic activity
A	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0006259	biological_process	DNA metabolic process
A	0006281	biological_process	DNA repair
A	0007018	biological_process	microtubule-based movement
A	0008168	molecular_function	methyltransferase activity
A	0008569	molecular_function	minus-end-directed microtubule motor activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0030030	biological_process	cell projection organization
A	0030286	cellular_component	dynein complex
A	0032259	biological_process	methylation
A	0045505	molecular_function	dynein intermediate chain binding
A	0046872	molecular_function	metal ion binding
A	0051959	molecular_function	dynein light intermediate chain binding
B	0003677	molecular_function	DNA binding
B	0003824	molecular_function	catalytic activity
B	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0005886	cellular_component	plasma membrane
B	0005929	cellular_component	cilium
B	0006259	biological_process	DNA metabolic process
B	0006281	biological_process	DNA repair
B	0007018	biological_process	microtubule-based movement
B	0008168	molecular_function	methyltransferase activity
B	0008569	molecular_function	minus-end-directed microtubule motor activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0030030	biological_process	cell projection organization
B	0030286	cellular_component	dynein complex
B	0032259	biological_process	methylation
B	0045505	molecular_function	dynein intermediate chain binding
B	0046872	molecular_function	metal ion binding
B	0051959	molecular_function	dynein light intermediate chain binding
C	0000242	cellular_component	pericentriolar material
C	0000922	cellular_component	spindle pole
C	0005515	molecular_function	protein binding
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005856	cellular_component	cytoskeleton
C	0005868	cellular_component	cytoplasmic dynein complex
C	0005929	cellular_component	cilium
C	0030030	biological_process	cell projection organization
C	0031021	cellular_component	interphase microtubule organizing center
C	0035721	biological_process	intraciliary retrograde transport
C	0042073	biological_process	intraciliary transport
C	0045503	molecular_function	dynein light chain binding
C	0045504	molecular_function	dynein heavy chain binding
C	0048704	biological_process	embryonic skeletal system morphogenesis
C	0060271	biological_process	cilium assembly
C	0097542	cellular_component	ciliary tip
C	0097546	cellular_component	ciliary base
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005814	cellular_component	centriole
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005868	cellular_component	cytoplasmic dynein complex
D	0005929	cellular_component	cilium
D	0005930	cellular_component	axoneme
D	0030175	cellular_component	filopodium
D	0035721	biological_process	intraciliary retrograde transport
D	0036064	cellular_component	ciliary basal body
D	0042073	biological_process	intraciliary transport
D	0042995	cellular_component	cell projection
D	0045503	molecular_function	dynein light chain binding
D	0045504	molecular_function	dynein heavy chain binding
D	0060271	biological_process	cilium assembly
D	0097014	cellular_component	ciliary plasm
D	0097542	cellular_component	ciliary tip
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005794	cellular_component	Golgi apparatus
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005868	cellular_component	cytoplasmic dynein complex
E	0005874	cellular_component	microtubule
E	0005881	cellular_component	cytoplasmic microtubule
E	0005929	cellular_component	cilium
E	0005930	cellular_component	axoneme
E	0007368	biological_process	determination of left/right symmetry
E	0030030	biological_process	cell projection organization
E	0030286	cellular_component	dynein complex
E	0031514	cellular_component	motile cilium
E	0035721	biological_process	intraciliary retrograde transport
E	0035735	biological_process	intraciliary transport involved in cilium assembly
E	0035869	cellular_component	ciliary transition zone
E	0036064	cellular_component	ciliary basal body
E	0045177	cellular_component	apical part of cell
E	0045504	molecular_function	dynein heavy chain binding
E	0060271	biological_process	cilium assembly
E	0097542	cellular_component	ciliary tip
E	1902017	biological_process	regulation of cilium assembly
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005794	cellular_component	Golgi apparatus
F	0005813	cellular_component	centrosome
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005868	cellular_component	cytoplasmic dynein complex
F	0005874	cellular_component	microtubule
F	0005881	cellular_component	cytoplasmic microtubule
F	0005929	cellular_component	cilium
F	0005930	cellular_component	axoneme
F	0007368	biological_process	determination of left/right symmetry
F	0030030	biological_process	cell projection organization
F	0030286	cellular_component	dynein complex
F	0031514	cellular_component	motile cilium
F	0035721	biological_process	intraciliary retrograde transport
F	0035735	biological_process	intraciliary transport involved in cilium assembly
F	0035869	cellular_component	ciliary transition zone
F	0036064	cellular_component	ciliary basal body
F	0045177	cellular_component	apical part of cell
F	0045504	molecular_function	dynein heavy chain binding
F	0060271	biological_process	cilium assembly
F	0097542	cellular_component	ciliary tip
F	1902017	biological_process	regulation of cilium assembly
G	0003777	molecular_function	microtubule motor activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005813	cellular_component	centrosome
G	0005856	cellular_component	cytoskeleton
G	0005868	cellular_component	cytoplasmic dynein complex
G	0005874	cellular_component	microtubule
G	0005929	cellular_component	cilium
G	0007018	biological_process	microtubule-based movement
G	0007632	biological_process	visual behavior
G	0016020	cellular_component	membrane
G	0030286	cellular_component	dynein complex
G	0045505	molecular_function	dynein intermediate chain binding
G	0097542	cellular_component	ciliary tip
H	0003777	molecular_function	microtubule motor activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005856	cellular_component	cytoskeleton
H	0005868	cellular_component	cytoplasmic dynein complex
H	0005874	cellular_component	microtubule
H	0005929	cellular_component	cilium
H	0007018	biological_process	microtubule-based movement
H	0007632	biological_process	visual behavior
H	0016020	cellular_component	membrane
H	0030286	cellular_component	dynein complex
H	0045505	molecular_function	dynein intermediate chain binding
H	0097542	cellular_component	ciliary tip
I	0000776	cellular_component	kinetochore
I	0004857	molecular_function	enzyme inhibitor activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005694	cellular_component	chromosome
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005813	cellular_component	centrosome
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005868	cellular_component	cytoplasmic dynein complex
I	0005874	cellular_component	microtubule
I	0005875	cellular_component	microtubule associated complex
I	0005886	cellular_component	plasma membrane
I	0005929	cellular_component	cilium
I	0006915	biological_process	apoptotic process
I	0006974	biological_process	DNA damage response
I	0007017	biological_process	microtubule-based process
I	0007286	biological_process	spermatid development
I	0008180	cellular_component	COP9 signalosome
I	0015630	cellular_component	microtubule cytoskeleton
I	0016020	cellular_component	membrane
I	0019899	molecular_function	enzyme binding
I	0021762	biological_process	substantia nigra development
I	0030141	cellular_component	secretory granule
I	0030235	molecular_function	nitric-oxide synthase regulator activity
I	0030286	cellular_component	dynein complex
I	0035721	biological_process	intraciliary retrograde transport
I	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
I	0035861	cellular_component	site of double-strand break
I	0036487	molecular_function	nitric-oxide synthase inhibitor activity
I	0042326	biological_process	negative regulation of phosphorylation
I	0042802	molecular_function	identical protein binding
I	0044458	biological_process	motile cilium assembly
I	0044877	molecular_function	protein-containing complex binding
I	0045019	biological_process	negative regulation of nitric oxide biosynthetic process
I	0045505	molecular_function	dynein intermediate chain binding
I	0060703	molecular_function	deoxyribonuclease inhibitor activity
I	0070821	cellular_component	tertiary granule membrane
I	0072686	cellular_component	mitotic spindle
I	0097110	molecular_function	scaffold protein binding
I	0097542	cellular_component	ciliary tip
I	0101003	cellular_component	ficolin-1-rich granule membrane
I	0110027	biological_process	negative regulation of DNA strand resection involved in replication fork processing
I	1904115	cellular_component	axon cytoplasm
J	0000776	cellular_component	kinetochore
J	0004857	molecular_function	enzyme inhibitor activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005694	cellular_component	chromosome
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005813	cellular_component	centrosome
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0005868	cellular_component	cytoplasmic dynein complex
J	0005874	cellular_component	microtubule
J	0005875	cellular_component	microtubule associated complex
J	0005886	cellular_component	plasma membrane
J	0005929	cellular_component	cilium
J	0006915	biological_process	apoptotic process
J	0006974	biological_process	DNA damage response
J	0007017	biological_process	microtubule-based process
J	0007286	biological_process	spermatid development
J	0008180	cellular_component	COP9 signalosome
J	0015630	cellular_component	microtubule cytoskeleton
J	0016020	cellular_component	membrane
J	0019899	molecular_function	enzyme binding
J	0021762	biological_process	substantia nigra development
J	0030141	cellular_component	secretory granule
J	0030235	molecular_function	nitric-oxide synthase regulator activity
J	0030286	cellular_component	dynein complex
J	0035721	biological_process	intraciliary retrograde transport
J	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
J	0035861	cellular_component	site of double-strand break
J	0036487	molecular_function	nitric-oxide synthase inhibitor activity
J	0042326	biological_process	negative regulation of phosphorylation
J	0042802	molecular_function	identical protein binding
J	0044458	biological_process	motile cilium assembly
J	0044877	molecular_function	protein-containing complex binding
J	0045019	biological_process	negative regulation of nitric oxide biosynthetic process
J	0045505	molecular_function	dynein intermediate chain binding
J	0060703	molecular_function	deoxyribonuclease inhibitor activity
J	0070821	cellular_component	tertiary granule membrane
J	0072686	cellular_component	mitotic spindle
J	0097110	molecular_function	scaffold protein binding
J	0097542	cellular_component	ciliary tip
J	0101003	cellular_component	ficolin-1-rich granule membrane
J	0110027	biological_process	negative regulation of DNA strand resection involved in replication fork processing
J	1904115	cellular_component	axon cytoplasm
K	0000776	cellular_component	kinetochore
K	0004857	molecular_function	enzyme inhibitor activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005694	cellular_component	chromosome
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005813	cellular_component	centrosome
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0005868	cellular_component	cytoplasmic dynein complex
K	0005874	cellular_component	microtubule
K	0005875	cellular_component	microtubule associated complex
K	0005886	cellular_component	plasma membrane
K	0005929	cellular_component	cilium
K	0006915	biological_process	apoptotic process
K	0006974	biological_process	DNA damage response
K	0007017	biological_process	microtubule-based process
K	0007286	biological_process	spermatid development
K	0008180	cellular_component	COP9 signalosome
K	0015630	cellular_component	microtubule cytoskeleton
K	0016020	cellular_component	membrane
K	0019899	molecular_function	enzyme binding
K	0021762	biological_process	substantia nigra development
K	0030141	cellular_component	secretory granule
K	0030235	molecular_function	nitric-oxide synthase regulator activity
K	0030286	cellular_component	dynein complex
K	0035721	biological_process	intraciliary retrograde transport
K	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
K	0035861	cellular_component	site of double-strand break
K	0036487	molecular_function	nitric-oxide synthase inhibitor activity
K	0042326	biological_process	negative regulation of phosphorylation
K	0042802	molecular_function	identical protein binding
K	0044458	biological_process	motile cilium assembly
K	0044877	molecular_function	protein-containing complex binding
K	0045019	biological_process	negative regulation of nitric oxide biosynthetic process
K	0045505	molecular_function	dynein intermediate chain binding
K	0060703	molecular_function	deoxyribonuclease inhibitor activity
K	0070821	cellular_component	tertiary granule membrane
K	0072686	cellular_component	mitotic spindle
K	0097110	molecular_function	scaffold protein binding
K	0097542	cellular_component	ciliary tip
K	0101003	cellular_component	ficolin-1-rich granule membrane
K	0110027	biological_process	negative regulation of DNA strand resection involved in replication fork processing
K	1904115	cellular_component	axon cytoplasm
L	0000776	cellular_component	kinetochore
L	0004857	molecular_function	enzyme inhibitor activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005694	cellular_component	chromosome
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005813	cellular_component	centrosome
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0005868	cellular_component	cytoplasmic dynein complex
L	0005874	cellular_component	microtubule
L	0005875	cellular_component	microtubule associated complex
L	0005886	cellular_component	plasma membrane
L	0005929	cellular_component	cilium
L	0006915	biological_process	apoptotic process
L	0006974	biological_process	DNA damage response
L	0007017	biological_process	microtubule-based process
L	0007286	biological_process	spermatid development
L	0008180	cellular_component	COP9 signalosome
L	0015630	cellular_component	microtubule cytoskeleton
L	0016020	cellular_component	membrane
L	0019899	molecular_function	enzyme binding
L	0021762	biological_process	substantia nigra development
L	0030141	cellular_component	secretory granule
L	0030235	molecular_function	nitric-oxide synthase regulator activity
L	0030286	cellular_component	dynein complex
L	0035721	biological_process	intraciliary retrograde transport
L	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
L	0035861	cellular_component	site of double-strand break
L	0036487	molecular_function	nitric-oxide synthase inhibitor activity
L	0042326	biological_process	negative regulation of phosphorylation
L	0042802	molecular_function	identical protein binding
L	0044458	biological_process	motile cilium assembly
L	0044877	molecular_function	protein-containing complex binding
L	0045019	biological_process	negative regulation of nitric oxide biosynthetic process
L	0045505	molecular_function	dynein intermediate chain binding
L	0060703	molecular_function	deoxyribonuclease inhibitor activity
L	0070821	cellular_component	tertiary granule membrane
L	0072686	cellular_component	mitotic spindle
L	0097110	molecular_function	scaffold protein binding
L	0097542	cellular_component	ciliary tip
L	0101003	cellular_component	ficolin-1-rich granule membrane
L	0110027	biological_process	negative regulation of DNA strand resection involved in replication fork processing
L	1904115	cellular_component	axon cytoplasm
M	0000776	cellular_component	kinetochore
M	0004857	molecular_function	enzyme inhibitor activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005694	cellular_component	chromosome
M	0005737	cellular_component	cytoplasm
M	0005739	cellular_component	mitochondrion
M	0005813	cellular_component	centrosome
M	0005829	cellular_component	cytosol
M	0005856	cellular_component	cytoskeleton
M	0005868	cellular_component	cytoplasmic dynein complex
M	0005874	cellular_component	microtubule
M	0005875	cellular_component	microtubule associated complex
M	0005886	cellular_component	plasma membrane
M	0005929	cellular_component	cilium
M	0006915	biological_process	apoptotic process
M	0006974	biological_process	DNA damage response
M	0007017	biological_process	microtubule-based process
M	0007286	biological_process	spermatid development
M	0008180	cellular_component	COP9 signalosome
M	0015630	cellular_component	microtubule cytoskeleton
M	0016020	cellular_component	membrane
M	0019899	molecular_function	enzyme binding
M	0021762	biological_process	substantia nigra development
M	0030141	cellular_component	secretory granule
M	0030235	molecular_function	nitric-oxide synthase regulator activity
M	0030286	cellular_component	dynein complex
M	0035721	biological_process	intraciliary retrograde transport
M	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
M	0035861	cellular_component	site of double-strand break
M	0036487	molecular_function	nitric-oxide synthase inhibitor activity
M	0042326	biological_process	negative regulation of phosphorylation
M	0042802	molecular_function	identical protein binding
M	0044458	biological_process	motile cilium assembly
M	0044877	molecular_function	protein-containing complex binding
M	0045019	biological_process	negative regulation of nitric oxide biosynthetic process
M	0045505	molecular_function	dynein intermediate chain binding
M	0060703	molecular_function	deoxyribonuclease inhibitor activity
M	0070821	cellular_component	tertiary granule membrane
M	0072686	cellular_component	mitotic spindle
M	0097110	molecular_function	scaffold protein binding
M	0097542	cellular_component	ciliary tip
M	0101003	cellular_component	ficolin-1-rich granule membrane
M	0110027	biological_process	negative regulation of DNA strand resection involved in replication fork processing
M	1904115	cellular_component	axon cytoplasm
N	0000776	cellular_component	kinetochore
N	0004857	molecular_function	enzyme inhibitor activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005694	cellular_component	chromosome
N	0005737	cellular_component	cytoplasm
N	0005739	cellular_component	mitochondrion
N	0005813	cellular_component	centrosome
N	0005829	cellular_component	cytosol
N	0005856	cellular_component	cytoskeleton
N	0005868	cellular_component	cytoplasmic dynein complex
N	0005874	cellular_component	microtubule
N	0005875	cellular_component	microtubule associated complex
N	0005886	cellular_component	plasma membrane
N	0005929	cellular_component	cilium
N	0006915	biological_process	apoptotic process
N	0006974	biological_process	DNA damage response
N	0007017	biological_process	microtubule-based process
N	0007286	biological_process	spermatid development
N	0008180	cellular_component	COP9 signalosome
N	0015630	cellular_component	microtubule cytoskeleton
N	0016020	cellular_component	membrane
N	0019899	molecular_function	enzyme binding
N	0021762	biological_process	substantia nigra development
N	0030141	cellular_component	secretory granule
N	0030235	molecular_function	nitric-oxide synthase regulator activity
N	0030286	cellular_component	dynein complex
N	0035721	biological_process	intraciliary retrograde transport
N	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
N	0035861	cellular_component	site of double-strand break
N	0036487	molecular_function	nitric-oxide synthase inhibitor activity
N	0042326	biological_process	negative regulation of phosphorylation
N	0042802	molecular_function	identical protein binding
N	0044458	biological_process	motile cilium assembly
N	0044877	molecular_function	protein-containing complex binding
N	0045019	biological_process	negative regulation of nitric oxide biosynthetic process
N	0045505	molecular_function	dynein intermediate chain binding
N	0060703	molecular_function	deoxyribonuclease inhibitor activity
N	0070821	cellular_component	tertiary granule membrane
N	0072686	cellular_component	mitotic spindle
N	0097110	molecular_function	scaffold protein binding
N	0097542	cellular_component	ciliary tip
N	0101003	cellular_component	ficolin-1-rich granule membrane
N	0110027	biological_process	negative regulation of DNA strand resection involved in replication fork processing
N	1904115	cellular_component	axon cytoplasm

Functional Information from PROSITE/UniProt

site_id	PS00374
Number of Residues	7
Details	MGMT Methylated-DNA--protein-cysteine methyltransferase active site. IPCHRVV

Chain	Residue	Details
A	ILE-63-VAL-57

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site_id	PS01239
Number of Residues	15
Details	DYNEIN_LIGHT_1 Dynein light chain type 1 signature. HcIvGRnFGSyVTHE

Chain	Residue	Details
I	HIS55-GLU69

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
I	LYS36
J	LYS36
K	LYS36
L	LYS36
M	LYS36
N	LYS36

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site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:15193260, ECO:0000269|PubMed:30464262, ECO:0000269|PubMed:37696958

Chain	Residue	Details
I	SER88
J	SER88
K	SER88
L	SER88
M	SER88
N	SER88

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site_id	SWS_FT_FI3
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
I	LYS43
N	LYS43
J	LYS43
K	LYS43
L	LYS43
M	LYS43

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