6RLA
Structure of the dynein-2 complex; motor domains
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003908 | molecular_function | methylated-DNA-[protein]-cysteine S-methyltransferase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005874 | cellular_component | microtubule |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005929 | cellular_component | cilium |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0006281 | biological_process | DNA repair |
| A | 0006996 | biological_process | organelle organization |
| A | 0007018 | biological_process | microtubule-based movement |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008569 | molecular_function | minus-end-directed microtubule motor activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0030030 | biological_process | cell projection organization |
| A | 0030286 | cellular_component | dynein complex |
| A | 0032259 | biological_process | methylation |
| A | 0045505 | molecular_function | dynein intermediate chain binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051959 | molecular_function | dynein light intermediate chain binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003908 | molecular_function | methylated-DNA-[protein]-cysteine S-methyltransferase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0005874 | cellular_component | microtubule |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005929 | cellular_component | cilium |
| B | 0006259 | biological_process | DNA metabolic process |
| B | 0006281 | biological_process | DNA repair |
| B | 0006996 | biological_process | organelle organization |
| B | 0007018 | biological_process | microtubule-based movement |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008569 | molecular_function | minus-end-directed microtubule motor activity |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0030030 | biological_process | cell projection organization |
| B | 0030286 | cellular_component | dynein complex |
| B | 0032259 | biological_process | methylation |
| B | 0045505 | molecular_function | dynein intermediate chain binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051959 | molecular_function | dynein light intermediate chain binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue ADP A 4401 |
| Chain | Residue |
| A | LEU1662 |
| A | ARG1867 |
| A | ASP2072 |
| A | VAL1663 |
| A | GLY1692 |
| A | THR1693 |
| A | GLY1694 |
| A | LYS1695 |
| A | THR1696 |
| A | GLU1697 |
| A | LEU1866 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue ATP A 4402 |
| Chain | Residue |
| A | TYR1952 |
| A | GLU1953 |
| A | GLN1958 |
| A | PRO1980 |
| A | SER1981 |
| A | GLY1982 |
| A | ALA1983 |
| A | GLY1984 |
| A | LYS1985 |
| A | SER1986 |
| A | THR1987 |
| A | GLU2095 |
| A | SER2124 |
| A | LEU2125 |
| A | ARG2420 |
| A | MG4403 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 4403 |
| Chain | Residue |
| A | SER1986 |
| A | GLU2095 |
| A | ATP4402 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue ADP A 4404 |
| Chain | Residue |
| A | LEU2260 |
| A | MET2268 |
| A | GLY2294 |
| A | CYS2295 |
| A | GLY2296 |
| A | LYS2297 |
| A | GLY2298 |
| A | MET2299 |
| A | LYS2359 |
| A | ILE2441 |
| A | THR2500 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue ADP A 4405 |
| Chain | Residue |
| A | ASP2626 |
| A | LEU2628 |
| A | PHE2630 |
| A | VAL2633 |
| A | GLY2658 |
| A | VAL2659 |
| A | GLY2660 |
| A | ARG2661 |
| A | ARG2662 |
| A | THR2663 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | binding site for residue ADP B 4401 |
| Chain | Residue |
| B | LEU1662 |
| B | VAL1663 |
| B | GLY1692 |
| B | THR1693 |
| B | GLY1694 |
| B | LYS1695 |
| B | THR1696 |
| B | GLU1697 |
| B | LEU1866 |
| B | ARG1867 |
| B | ASP2072 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | binding site for residue ATP B 4402 |
| Chain | Residue |
| B | TYR1952 |
| B | GLU1953 |
| B | GLN1958 |
| B | PRO1980 |
| B | SER1981 |
| B | GLY1982 |
| B | ALA1983 |
| B | GLY1984 |
| B | LYS1985 |
| B | SER1986 |
| B | THR1987 |
| B | GLU2095 |
| B | SER2124 |
| B | LEU2125 |
| B | ARG2420 |
| B | MG4403 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 4403 |
| Chain | Residue |
| B | SER1986 |
| B | GLU2095 |
| B | ATP4402 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | binding site for residue ADP B 4404 |
| Chain | Residue |
| B | LEU2260 |
| B | MET2268 |
| B | GLY2294 |
| B | CYS2295 |
| B | GLY2296 |
| B | LYS2297 |
| B | GLY2298 |
| B | MET2299 |
| B | LYS2359 |
| B | ILE2441 |
| B | THR2500 |
| site_id | AD1 |
| Number of Residues | 10 |
| Details | binding site for residue ADP B 4405 |
| Chain | Residue |
| B | ARG2661 |
| B | ARG2662 |
| B | THR2663 |
| B | ASP2626 |
| B | LEU2628 |
| B | PHE2630 |
| B | VAL2633 |
| B | GLY2658 |
| B | VAL2659 |
| B | GLY2660 |
Functional Information from PROSITE/UniProt
| site_id | PS00374 |
| Number of Residues | 7 |
| Details | MGMT Methylated-DNA--protein-cysteine methyltransferase active site. IPCHRVV |
| Chain | Residue | Details |
| A | ILE-63-VAL-57 |
