Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6RKC

Inter-dimeric interface controls function and stability of S-methionine adenosyltransferase from U. urealiticum

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004478	molecular_function	methionine adenosyltransferase activity
A	0005524	molecular_function	ATP binding
A	0006556	biological_process	S-adenosylmethionine biosynthetic process
B	0004478	molecular_function	methionine adenosyltransferase activity
B	0005524	molecular_function	ATP binding
B	0006556	biological_process	S-adenosylmethionine biosynthetic process
C	0004478	molecular_function	methionine adenosyltransferase activity
C	0005524	molecular_function	ATP binding
C	0006556	biological_process	S-adenosylmethionine biosynthetic process
D	0004478	molecular_function	methionine adenosyltransferase activity
D	0005524	molecular_function	ATP binding
D	0006556	biological_process	S-adenosylmethionine biosynthetic process
E	0004478	molecular_function	methionine adenosyltransferase activity
E	0005524	molecular_function	ATP binding
E	0006556	biological_process	S-adenosylmethionine biosynthetic process
F	0004478	molecular_function	methionine adenosyltransferase activity
F	0005524	molecular_function	ATP binding
F	0006556	biological_process	S-adenosylmethionine biosynthetic process
G	0004478	molecular_function	methionine adenosyltransferase activity
G	0005524	molecular_function	ATP binding
G	0006556	biological_process	S-adenosylmethionine biosynthetic process
H	0004478	molecular_function	methionine adenosyltransferase activity
H	0005524	molecular_function	ATP binding
H	0006556	biological_process	S-adenosylmethionine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue K A 401

Chain	Residue
A	ASP231
A	THR232
A	MG402
A	PPK405
B	GLU44
B	HOH516

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 402

Chain	Residue
A	K401
A	PPK405
A	ASP18
A	ASP231
A	THR232

site_id	AC3
Number of Residues	3
Details	binding site for residue MG A 403

Chain	Residue
A	ASP113
A	ASP264
A	PPK409

site_id	AC4
Number of Residues	19
Details	binding site for residue SAM A 404

Chain	Residue
A	HIS16
A	PRO17
A	ASP158
A	LYS160
A	SER220
A	ARG222
A	PHE223
A	ASP231
A	PPK405
A	HOH501
A	HOH503
B	ALA42
B	GLU57
B	GLN93
B	ASP96
B	ILE97
B	LYS262
B	ILE295
B	HOH517

site_id	AC5
Number of Residues	14
Details	binding site for residue PPK A 405

Chain	Residue
A	HIS16
A	ASP18
A	LYS160
A	ARG237
A	LYS238
A	K401
A	MG402
A	SAM404
A	MG407
B	ASP113
B	GLY253
B	ALA254
B	LYS258
B	ASP264

site_id	AC6
Number of Residues	9
Details	binding site for residue SAM A 406

Chain	Residue
A	ILE58
A	THR59
A	THR60
A	ALA62
A	TYR63
A	VAL64
A	VAL66
D	GLU81
D	ASN82

site_id	AC7
Number of Residues	2
Details	binding site for residue MG A 407

Chain	Residue
A	PPK405
B	ASP264

site_id	AC8
Number of Residues	5
Details	binding site for residue K A 408

Chain	Residue
A	GLU44
A	PPK409
B	ASP231
B	THR232
B	MG401

site_id	AC9
Number of Residues	14
Details	binding site for residue PPK A 409

Chain	Residue
A	ASP113
A	GLY253
A	ALA254
A	LYS258
A	MG403
A	K408
B	HIS16
B	ASP18
B	LYS160
B	ASP231
B	ARG237
B	LYS238
B	MG401
B	SAM402

site_id	AD1
Number of Residues	5
Details	binding site for residue MG B 401

Chain	Residue
A	K408
A	PPK409
B	ASP18
B	ASP231
B	THR232

site_id	AD2
Number of Residues	18
Details	binding site for residue SAM B 402

Chain	Residue
B	HOH508
A	ALA42
A	GLU57
A	GLN93
A	ASP96
A	ILE97
A	LYS262
A	ILE295
A	PPK409
A	HOH521
B	HIS16
B	PRO17
B	ASP158
B	SER220
B	ARG222
B	PHE223
B	ASP231
B	HOH501

site_id	AD3
Number of Residues	13
Details	binding site for residue SAM B 403

Chain	Residue
B	ILE58
B	THR59
B	THR60
B	HIS61
B	ALA62
B	VAL64
B	VAL66
B	VAL90
B	LYS92
B	HOH505
C	TRP71
C	GLU81
C	ASN82

site_id	AD4
Number of Residues	5
Details	binding site for residue K C 401

Chain	Residue
C	ASP231
C	THR232
C	MG402
C	PPK405
D	GLU44

site_id	AD5
Number of Residues	3
Details	binding site for residue MG C 402

Chain	Residue
C	ASP18
C	K401
C	PPK405

site_id	AD6
Number of Residues	4
Details	binding site for residue MG C 403

Chain	Residue
C	ASP113
C	GLN114
C	ASP264
C	PPK408

site_id	AD7
Number of Residues	14
Details	binding site for residue SAM C 404

Chain	Residue
C	HIS16
C	ASP158
C	SER220
C	ARG222
C	PHE223
C	ASP231
C	PPK405
D	GLU57
D	GLN93
D	ASP96
D	ILE97
D	GLY112
D	LYS262
D	HOH501

site_id	AD8
Number of Residues	15
Details	binding site for residue PPK C 405

Chain	Residue
C	HIS16
C	ASP18
C	LYS160
C	ARG237
C	LYS238
C	K401
C	MG402
C	SAM404
C	MG407
C	HOH504
D	ASP113
D	GLY253
D	ALA254
D	LYS258
D	ASP264

site_id	AD9
Number of Residues	9
Details	binding site for residue SAM C 406

Chain	Residue
B	GLU81
B	ASN82
C	ILE58
C	THR59
C	THR60
C	HIS61
C	ALA62
C	VAL64
C	VAL66

site_id	AE1
Number of Residues	4
Details	binding site for residue MG C 407

Chain	Residue
C	PPK405
C	HOH504
D	GLY253
D	ASP264

site_id	AE2
Number of Residues	13
Details	binding site for residue PPK C 408

Chain	Residue
C	ASP113
C	GLY253
C	ALA254
C	LYS258
C	ASP264
C	MG403
D	HIS16
D	ASP18
D	LYS160
D	LYS238
D	MG401
D	SAM402
D	HOH503

site_id	AE3
Number of Residues	3
Details	binding site for residue MG D 401

Chain	Residue
C	PPK408
D	ASP18
D	ARG237

site_id	AE4
Number of Residues	16
Details	binding site for residue SAM D 402

Chain	Residue
C	ALA42
C	GLU57
C	GLN93
C	ASP96
C	ILE97
C	GLY112
C	LYS262
C	PPK408
C	HOH514
D	HIS16
D	PRO17
D	ASP158
D	SER220
D	ARG222
D	PHE223
D	ASP231

site_id	AE5
Number of Residues	12
Details	binding site for residue SAM D 403

Chain	Residue
A	TRP71
A	GLU81
A	ASN82
D	ILE58
D	THR59
D	THR60
D	HIS61
D	ALA62
D	VAL64
D	VAL66
D	VAL90
D	LYS92

site_id	AE6
Number of Residues	6
Details	binding site for residue K E 401

Chain	Residue
E	ASP231
E	THR232
E	MG402
E	PPK405
E	HOH513
F	GLU44

site_id	AE7
Number of Residues	4
Details	binding site for residue MG E 402

Chain	Residue
E	ASP18
E	ASP231
E	K401
E	PPK405

site_id	AE8
Number of Residues	4
Details	binding site for residue MG E 403

Chain	Residue
E	GLY253
E	ASP264
E	PPK409
F	HOH502

site_id	AE9
Number of Residues	18
Details	binding site for residue SAM E 404

Chain	Residue
E	HIS16
E	PRO17
E	ASP158
E	LYS160
E	SER220
E	ARG222
E	PHE223
E	ASP231
E	PPK405
F	ALA42
F	GLU57
F	GLN93
F	ASP96
F	ILE97
F	GLY112
F	ASP113
F	LYS262
F	HOH505

site_id	AF1
Number of Residues	15
Details	binding site for residue PPK E 405

Chain	Residue
E	HIS16
E	ASP18
E	LYS160
E	ARG237
E	LYS238
E	K401
E	MG402
E	SAM404
E	MG407
E	HOH502
F	ASP113
F	GLY253
F	ALA254
F	LYS258
F	ASP264

site_id	AF2
Number of Residues	9
Details	binding site for residue SAM E 406

Chain	Residue
E	ILE58
E	HIS61
E	ALA62
E	VAL64
E	VAL66
E	VAL90
E	LYS92
E	HOH509
H	GLU81

site_id	AF3
Number of Residues	4
Details	binding site for residue MG E 407

Chain	Residue
E	PPK405
E	HOH502
F	ASP113
F	ASP264

site_id	AF4
Number of Residues	5
Details	binding site for residue K E 408

Chain	Residue
E	GLU44
E	PPK409
F	ASP231
F	THR232
F	MG401

site_id	AF5
Number of Residues	16
Details	binding site for residue PPK E 409

Chain	Residue
E	ASP113
E	GLY253
E	ALA254
E	LYS258
E	ASP264
E	MG403
E	K408
F	HIS16
F	ASP18
F	LYS160
F	ASP231
F	ARG237
F	LYS238
F	MG401
F	SAM402
F	HOH502

site_id	AF6
Number of Residues	4
Details	binding site for residue MG F 401

Chain	Residue
E	K408
E	PPK409
F	ASP18
F	ARG237

site_id	AF7
Number of Residues	16
Details	binding site for residue SAM F 402

Chain	Residue
E	ALA42
E	GLU57
E	ILE97
E	ASP113
E	ILE295
E	PPK409
F	HIS16
F	PRO17
F	ASP158
F	LYS160
F	SER220
F	ARG222
F	PHE223
F	ASP231
F	HOH503
F	HOH512

site_id	AF8
Number of Residues	11
Details	binding site for residue SAM F 403

Chain	Residue
F	ILE58
F	THR59
F	THR60
F	HIS61
F	ALA62
F	TYR63
F	VAL64
F	HOH504
G	TRP71
G	GLU81
G	ASN82

site_id	AF9
Number of Residues	5
Details	binding site for residue K G 401

Chain	Residue
G	ASP231
G	THR232
G	MG402
G	PPK404
H	GLU44

site_id	AG1
Number of Residues	4
Details	binding site for residue MG G 402

Chain	Residue
G	ASP18
G	ARG237
G	K401
G	PPK404

site_id	AG2
Number of Residues	19
Details	binding site for residue SAM G 403

Chain	Residue
G	HIS16
G	PRO17
G	ASP158
G	SER220
G	ARG222
G	PHE223
G	ILE225
G	ASP231
G	PPK404
G	HOH509
H	ALA42
H	GLU57
H	GLN93
H	ASP96
H	ILE97
H	GLY112
H	ASP113
H	LYS262
H	ILE295

site_id	AG3
Number of Residues	15
Details	binding site for residue PPK G 404

Chain	Residue
G	HIS16
G	ASP18
G	LYS160
G	ASP231
G	ARG237
G	LYS238
G	K401
G	MG402
G	SAM403
G	MG407
H	ASP113
H	GLY253
H	ALA254
H	LYS258
H	ASP264

site_id	AG4
Number of Residues	13
Details	binding site for residue SAM G 405

Chain	Residue
F	TRP71
F	GLU81
F	ASN82
G	ILE58
G	THR59
G	THR60
G	HIS61
G	ALA62
G	TYR63
G	VAL64
G	VAL90
G	HOH501
G	HOH505

site_id	AG5
Number of Residues	4
Details	binding site for residue MG G 406

Chain	Residue
G	ASP113
G	ASP264
G	PPK409
H	LYS160

site_id	AG6
Number of Residues	3
Details	binding site for residue MG G 407

Chain	Residue
G	PPK404
H	ASP113
H	ASP264

site_id	AG7
Number of Residues	5
Details	binding site for residue K G 408

Chain	Residue
G	GLU44
G	PPK409
H	ASP231
H	THR232
H	MG401

site_id	AG8
Number of Residues	14
Details	binding site for residue PPK G 409

Chain	Residue
G	ASP113
G	ALA254
G	LYS258
G	ASP264
G	MG406
G	K408
H	HIS16
H	ASP18
H	LYS160
H	ASP231
H	ARG237
H	LYS238
H	MG401
H	SAM402

site_id	AG9
Number of Residues	3
Details	binding site for residue MG H 401

Chain	Residue
G	K408
G	PPK409
H	ASP18

site_id	AH1
Number of Residues	15
Details	binding site for residue SAM H 402

Chain	Residue
G	ALA42
G	GLU57
G	GLN93
G	ASP96
G	ILE97
G	LYS262
G	PPK409
G	HOH502
H	HIS16
H	PRO17
H	ASP158
H	SER220
H	ARG222
H	PHE223
H	ASP231

site_id	AH2
Number of Residues	8
Details	binding site for residue SAM H 403

Chain	Residue
E	TRP71
E	GLU81
E	ASN82
H	ILE58
H	THR60
H	HIS61
H	ALA62
H	VAL90

Functional Information from PROSITE/UniProt

site_id	PS00376
Number of Residues	11
Details	ADOMET_SYNTHASE_1 S-adenosylmethionine synthase signature 1. GAGDQGivfGY

Chain	Residue	Details
A	GLY110-TYR120

site_id	PS00377
Number of Residues	9
Details	ADOMET_SYNTHASE_2 S-adenosylmethionine synthase signature 2. GGGAFSgKD

Chain	Residue	Details
A	GLY251-ASP259

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)