6RH8
Revisiting pH-gated conformational switch. Complex HK853 mutant H260A -RR468 mutant D53A pH 5.3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000155 | molecular_function | phosphorelay sensor kinase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0016310 | biological_process | phosphorylation |
| A | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| B | 0000155 | molecular_function | phosphorelay sensor kinase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0016310 | biological_process | phosphorylation |
| B | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| C | 0000156 | molecular_function | phosphorelay response regulator activity |
| C | 0000160 | biological_process | phosphorelay signal transduction system |
| C | 0003677 | molecular_function | DNA binding |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000156 | molecular_function | phosphorelay response regulator activity |
| D | 0000160 | biological_process | phosphorelay signal transduction system |
| D | 0003677 | molecular_function | DNA binding |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue ADP A 501 |
| Chain | Residue |
| A | ASN376 |
| A | VAL431 |
| A | GLY441 |
| A | THR442 |
| A | GLY443 |
| A | GLY445 |
| A | LEU446 |
| A | HOH632 |
| A | HOH634 |
| A | HOH649 |
| A | HOH655 |
| A | ASN380 |
| A | HOH661 |
| A | HOH666 |
| A | HOH680 |
| A | LYS383 |
| A | TYR384 |
| A | ASP411 |
| A | ILE416 |
| A | ILE424 |
| A | TYR429 |
| A | ARG430 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 502 |
| Chain | Residue |
| A | ASN300 |
| A | HIS301 |
| A | ASN304 |
| A | HOH604 |
| A | HOH606 |
| A | HOH607 |
| A | HOH668 |
| A | HOH685 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 503 |
| Chain | Residue |
| A | LYS270 |
| A | GLU274 |
| A | HOH605 |
| B | ASN300 |
| C | SER108 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 504 |
| Chain | Residue |
| A | PRO417 |
| A | ASP418 |
| A | HIS419 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 505 |
| Chain | Residue |
| A | ARG246 |
| A | GLU426 |
| A | GLN427 |
| site_id | AC6 |
| Number of Residues | 22 |
| Details | binding site for residue ADP B 501 |
| Chain | Residue |
| B | ASN376 |
| B | ASN380 |
| B | LYS383 |
| B | TYR384 |
| B | ASP411 |
| B | ILE416 |
| B | ILE424 |
| B | TYR429 |
| B | ARG430 |
| B | VAL431 |
| B | GLY441 |
| B | THR442 |
| B | GLY443 |
| B | GLY445 |
| B | LEU446 |
| B | HOH612 |
| B | HOH621 |
| B | HOH630 |
| B | HOH645 |
| B | HOH651 |
| B | HOH657 |
| B | HOH682 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| A | ASN300 |
| B | LYS270 |
| B | GLU274 |
| D | SER108 |
| D | GLN111 |
| D | HOH312 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 503 |
| Chain | Residue |
| B | HIS301 |
| B | ASN304 |
| B | HOH601 |
| B | HOH637 |
| B | HOH668 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 504 |
| Chain | Residue |
| B | ARG246 |
| B | GLN427 |
| B | HOH623 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 C 201 |
| Chain | Residue |
| A | GLU400 |
| A | LYS401 |
| A | ASP402 |
| C | LYS85 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 C 202 |
| Chain | Residue |
| C | ALA53 |
| C | ILE54 |
| C | MET55 |
| C | THR83 |
| C | ALA84 |
| C | LYS105 |
| C | HOH301 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 C 203 |
| Chain | Residue |
| A | HOH692 |
| C | ASP10 |
| C | SER11 |
| C | ALA12 |
| C | VAL13 |
| C | HOH304 |
| C | HOH321 |
| C | HOH343 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 C 204 |
| Chain | Residue |
| C | HOH305 |
| C | HOH323 |
| C | VAL102 |
| C | MET103 |
| C | ARG104 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 205 |
| Chain | Residue |
| C | ARG100 |
| C | HIS118 |
| C | HOH303 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 206 |
| Chain | Residue |
| C | HIS118 |
| C | GLU122 |
| C | HOH302 |
| site_id | AD7 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 D 201 |
| Chain | Residue |
| A | ARG314 |
| A | SER319 |
| A | HOH616 |
| B | LYS401 |
| D | GLY87 |
| D | GLU88 |
| D | GLU89 |
| D | ASP90 |
| D | HOH316 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 D 202 |
| Chain | Residue |
| B | LYS401 |
| B | ASP402 |
| D | LYS85 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 D 203 |
| Chain | Residue |
| B | SER346 |
| D | SER11 |
| D | ALA12 |
| D | VAL13 |
| D | HOH302 |
| D | HOH322 |
| D | HOH345 |
| site_id | AE1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 D 204 |
| Chain | Residue |
| D | ALA53 |
| D | ILE54 |
| D | MET55 |
| D | THR83 |
| D | ALA84 |
| D | LYS105 |
| D | HOH349 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 D 205 |
| Chain | Residue |
| D | MET103 |
| D | ARG104 |
| D | HOH301 |
| D | HOH315 |
| D | HOH319 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 D 206 |
| Chain | Residue |
| D | HIS118 |
| D | ASN121 |
| D | GLU122 |
