6RFQ
Cryo-EM structure of a respiratory complex I assembly intermediate with NDUFAF2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| 1 | 0003954 | molecular_function | NADH dehydrogenase activity |
| 1 | 0005739 | cellular_component | mitochondrion |
| 1 | 0005743 | cellular_component | mitochondrial inner membrane |
| 1 | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| 1 | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| 1 | 0009060 | biological_process | aerobic respiration |
| 1 | 0016020 | cellular_component | membrane |
| 1 | 0070469 | cellular_component | respirasome |
| 1 | 1902600 | biological_process | proton transmembrane transport |
| 2 | 0005739 | cellular_component | mitochondrion |
| 2 | 0005743 | cellular_component | mitochondrial inner membrane |
| 2 | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| 2 | 0070469 | cellular_component | respirasome |
| 2 | 1902600 | biological_process | proton transmembrane transport |
| 3 | 0005739 | cellular_component | mitochondrion |
| 3 | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| 3 | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| 3 | 0016020 | cellular_component | membrane |
| 3 | 0031966 | cellular_component | mitochondrial membrane |
| 3 | 0070469 | cellular_component | respirasome |
| 3 | 1902600 | biological_process | proton transmembrane transport |
| 4 | 0003954 | molecular_function | NADH dehydrogenase activity |
| 4 | 0005739 | cellular_component | mitochondrion |
| 4 | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| 4 | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| 4 | 0009060 | biological_process | aerobic respiration |
| 4 | 0015990 | biological_process | electron transport coupled proton transport |
| 4 | 0016020 | cellular_component | membrane |
| 4 | 0031966 | cellular_component | mitochondrial membrane |
| 4 | 0042773 | biological_process | ATP synthesis coupled electron transport |
| 4 | 0048039 | molecular_function | ubiquinone binding |
| 4 | 0070469 | cellular_component | respirasome |
| 5 | 0003954 | molecular_function | NADH dehydrogenase activity |
| 5 | 0005739 | cellular_component | mitochondrion |
| 5 | 0005743 | cellular_component | mitochondrial inner membrane |
| 5 | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| 5 | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| 5 | 0015990 | biological_process | electron transport coupled proton transport |
| 5 | 0042773 | biological_process | ATP synthesis coupled electron transport |
| 5 | 0070469 | cellular_component | respirasome |
| 6 | 0005739 | cellular_component | mitochondrion |
| 6 | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| 6 | 0016020 | cellular_component | membrane |
| 6 | 0031966 | cellular_component | mitochondrial membrane |
| 6 | 0070469 | cellular_component | respirasome |
| 6 | 1902600 | biological_process | proton transmembrane transport |
| 8 | 0005739 | cellular_component | mitochondrion |
| 8 | 0005743 | cellular_component | mitochondrial inner membrane |
| 8 | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| 8 | 0005758 | cellular_component | mitochondrial intermembrane space |
| 8 | 0016020 | cellular_component | membrane |
| 9 | 0005739 | cellular_component | mitochondrion |
| 9 | 0005743 | cellular_component | mitochondrial inner membrane |
| 9 | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| 9 | 0005758 | cellular_component | mitochondrial intermembrane space |
| 9 | 0032981 | biological_process | mitochondrial respiratory chain complex I assembly |
| 9 | 0070469 | cellular_component | respirasome |
| a | 0005739 | cellular_component | mitochondrion |
| a | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| a | 0016020 | cellular_component | membrane |
| A | 0003954 | molecular_function | NADH dehydrogenase activity |
| A | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016651 | molecular_function | oxidoreductase activity, acting on NAD(P)H |
| A | 0042773 | biological_process | ATP synthesis coupled electron transport |
| A | 0045333 | biological_process | cellular respiration |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051536 | molecular_function | iron-sulfur cluster binding |
| A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| B | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| B | 0010181 | molecular_function | FMN binding |
| B | 0045271 | cellular_component | respiratory chain complex I |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051287 | molecular_function | NAD binding |
| B | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| B | 0070469 | cellular_component | respirasome |
| B | 1902600 | biological_process | proton transmembrane transport |
| c | 0005739 | cellular_component | mitochondrion |
| c | 0005743 | cellular_component | mitochondrial inner membrane |
| c | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| c | 0022900 | biological_process | electron transport chain |
| c | 0032981 | biological_process | mitochondrial respiratory chain complex I assembly |
| c | 0070469 | cellular_component | respirasome |
| C | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| C | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
| C | 0016651 | molecular_function | oxidoreductase activity, acting on NAD(P)H |
| C | 0048038 | molecular_function | quinone binding |
| C | 0051287 | molecular_function | NAD binding |
| d | 0005739 | cellular_component | mitochondrion |
| d | 0005743 | cellular_component | mitochondrial inner membrane |
| d | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| d | 0070469 | cellular_component | respirasome |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005743 | cellular_component | mitochondrial inner membrane |
| D | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| D | 0070469 | cellular_component | respirasome |
| E | 0005739 | cellular_component | mitochondrion |
| E | 0044877 | molecular_function | protein-containing complex binding |
| E | 1901006 | biological_process | ubiquinone-6 biosynthetic process |
| f | 0005739 | cellular_component | mitochondrion |
| f | 0005743 | cellular_component | mitochondrial inner membrane |
| f | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| f | 0070469 | cellular_component | respirasome |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0005743 | cellular_component | mitochondrial inner membrane |
| F | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| F | 0022904 | biological_process | respiratory electron transport chain |
| g | 0016020 | cellular_component | membrane |
| G | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| G | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| G | 0016651 | molecular_function | oxidoreductase activity, acting on NAD(P)H |
| G | 1902600 | biological_process | proton transmembrane transport |
| H | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0045271 | cellular_component | respiratory chain complex I |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| i | 0016020 | cellular_component | membrane |
| I | 0003954 | molecular_function | NADH dehydrogenase activity |
| I | 0005739 | cellular_component | mitochondrion |
| I | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| I | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
| I | 0016020 | cellular_component | membrane |
| I | 0016651 | molecular_function | oxidoreductase activity, acting on NAD(P)H |
| I | 0032981 | biological_process | mitochondrial respiratory chain complex I assembly |
| I | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| j | 0016020 | cellular_component | membrane |
| J | 0005739 | cellular_component | mitochondrion |
| J | 0005743 | cellular_component | mitochondrial inner membrane |
| J | 0005744 | cellular_component | TIM23 mitochondrial import inner membrane translocase complex |
| J | 0008320 | molecular_function | protein transmembrane transporter activity |
| J | 0030150 | biological_process | protein import into mitochondrial matrix |
| J | 0032981 | biological_process | mitochondrial respiratory chain complex I assembly |
| k | 0005739 | cellular_component | mitochondrion |
| k | 0016020 | cellular_component | membrane |
| k | 0032981 | biological_process | mitochondrial respiratory chain complex I assembly |
| K | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| K | 0048038 | molecular_function | quinone binding |
| K | 0051536 | molecular_function | iron-sulfur cluster binding |
| K | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| L | 0005739 | cellular_component | mitochondrion |
| L | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| L | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| L | 0016020 | cellular_component | membrane |
| L | 0016651 | molecular_function | oxidoreductase activity, acting on NAD(P)H |
| L | 0031966 | cellular_component | mitochondrial membrane |
| L | 0042773 | biological_process | ATP synthesis coupled electron transport |
| L | 0070469 | cellular_component | respirasome |
| L | 1902600 | biological_process | proton transmembrane transport |
| O | 0000035 | molecular_function | acyl binding |
| O | 0000036 | molecular_function | acyl carrier activity |
| O | 0005739 | cellular_component | mitochondrion |
| O | 0006633 | biological_process | fatty acid biosynthetic process |
| O | 0009107 | biological_process | lipoate biosynthetic process |
| O | 0016226 | biological_process | iron-sulfur cluster assembly |
| O | 0099128 | cellular_component | mitochondrial [2Fe-2S] assembly complex |
| P | 0005739 | cellular_component | mitochondrion |
| P | 0005743 | cellular_component | mitochondrial inner membrane |
| P | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| P | 0006979 | biological_process | response to oxidative stress |
| P | 0070469 | cellular_component | respirasome |
| Q | 0000035 | molecular_function | acyl binding |
| Q | 0000036 | molecular_function | acyl carrier activity |
| Q | 0005739 | cellular_component | mitochondrion |
| Q | 0006633 | biological_process | fatty acid biosynthetic process |
| R | 0005739 | cellular_component | mitochondrion |
| R | 0005743 | cellular_component | mitochondrial inner membrane |
| R | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| R | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
| R | 0070469 | cellular_component | respirasome |
| U | 0005739 | cellular_component | mitochondrion |
| U | 0005743 | cellular_component | mitochondrial inner membrane |
| U | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| U | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
| U | 0070469 | cellular_component | respirasome |
| W | 0005739 | cellular_component | mitochondrion |
| W | 0005743 | cellular_component | mitochondrial inner membrane |
| W | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| W | 0016020 | cellular_component | membrane |
| W | 0070469 | cellular_component | respirasome |
| X | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| X | 0016020 | cellular_component | membrane |
| Y | 0005739 | cellular_component | mitochondrion |
| Y | 0005743 | cellular_component | mitochondrial inner membrane |
| Y | 0005747 | cellular_component | obsolete mitochondrial respiratory chain complex I |
| Y | 0022900 | biological_process | electron transport chain |
| Y | 0070469 | cellular_component | respirasome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue SF4 A 801 |
| Chain | Residue |
| A | HIS129 |
| A | GLY236 |
| A | PRO130 |
| A | CYS133 |
| A | CYS136 |
| A | GLN138 |
| A | CYS142 |
| A | LEU144 |
| A | ARG182 |
| A | VAL235 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue SF4 A 802 |
| Chain | Residue |
| A | CYS183 |
| A | CYS186 |
| A | THR187 |
| A | CYS189 |
| A | CYS233 |
| A | VAL235 |
| A | LEU238 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue FES A 803 |
| Chain | Residue |
| A | CYS69 |
| A | TYR70 |
| A | CYS80 |
| A | ARG81 |
| A | CYS83 |
| A | CYS97 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue SF4 B 501 |
| Chain | Residue |
| B | SER380 |
| B | CYS381 |
| B | GLY382 |
| B | GLN383 |
| B | CYS384 |
| B | CYS387 |
| B | THR425 |
| B | CYS427 |
| B | GLY430 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | binding site for residue FMN B 502 |
| Chain | Residue |
| B | GLY86 |
| B | ARG87 |
| B | GLY88 |
| B | LYS97 |
| B | ASN118 |
| B | ASP120 |
| B | GLU121 |
| B | GLY209 |
| B | GLU210 |
| B | GLU211 |
| B | VAL244 |
| B | THR245 |
| B | ASN246 |
| B | THR249 |
| B | ALA428 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | binding site for residue NDP E 401 |
| Chain | Residue |
| E | GLY60 |
| E | ASN62 |
| E | GLY63 |
| E | PHE64 |
| E | LEU65 |
| E | ARG85 |
| E | LEU128 |
| E | ILE129 |
| E | GLY130 |
| E | ARG131 |
| E | PHE138 |
| E | VAL143 |
| E | SER167 |
| E | ALA168 |
| E | PHE169 |
| E | LYS183 |
| E | MET205 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue FES H 301 |
| Chain | Residue |
| H | CYS127 |
| H | CYS132 |
| H | CYS168 |
| H | LEU169 |
| H | ALA171 |
| H | CYS172 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue SF4 I 301 |
| Chain | Residue |
| I | HIS118 |
| I | CYS140 |
| I | ILE145 |
| I | CYS169 |
| I | ILE170 |
| I | CYS172 |
| I | GLY173 |
| I | CYS175 |
| I | GLU186 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue SF4 I 302 |
| Chain | Residue |
| I | CYS130 |
| I | CYS133 |
| I | LYS134 |
| I | LEU135 |
| I | CYS136 |
| I | ILE147 |
| I | CYS179 |
| site_id | AD1 |
| Number of Residues | 15 |
| Details | binding site for residue 3PE I 303 |
| Chain | Residue |
| I | LEU80 |
| I | PHE84 |
| 1 | PRO184 |
| 1 | ILE188 |
| 1 | PHE190 |
| 1 | ILE191 |
| 1 | TRP295 |
| 1 | VAL296 |
| 1 | PHE303 |
| 1 | ASN307 |
| 1 | PHE311 |
| 1 | ILE315 |
| C | ARG269 |
| I | TYR77 |
| I | PHE78 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue 3PE J 201 |
| Chain | Residue |
| 4 | T7X504 |
| J | ASP93 |
| J | GLY94 |
| J | TRP95 |
| J | GLY130 |
| J | TRP134 |
| site_id | AD3 |
| Number of Residues | 12 |
| Details | binding site for residue LMN J 202 |
| Chain | Residue |
| 2 | TYR396 |
| 4 | VAL184 |
| J | TYR82 |
| J | LYS92 |
| J | ASP93 |
| J | HIS97 |
| J | TRP134 |
| J | THR135 |
| J | ALA145 |
| J | THR162 |
| J | PHE163 |
| J | TRP164 |
| site_id | AD4 |
| Number of Residues | 16 |
| Details | binding site for residue 3PE J 203 |
| Chain | Residue |
| 5 | ASN602 |
| 5 | LEU606 |
| 5 | LEU620 |
| 5 | THR624 |
| 5 | LEU628 |
| 5 | LEU630 |
| 5 | VAL634 |
| 5 | ILE649 |
| 5 | ILE652 |
| J | VAL35 |
| J | GLY38 |
| J | ALA39 |
| J | VAL42 |
| J | ALA46 |
| J | ARG47 |
| J | PHE139 |
| site_id | AD5 |
| Number of Residues | 16 |
| Details | binding site for residue CDL J 204 |
| Chain | Residue |
| 5 | ARG586 |
| 5 | LEU587 |
| 5 | GLY591 |
| 5 | ARG594 |
| 5 | LEU595 |
| 5 | LYS598 |
| 5 | ILE647 |
| J | PRO116 |
| J | ALA117 |
| J | TRP121 |
| J | LEU124 |
| J | ALA128 |
| J | PHE132 |
| J | PHE139 |
| j | TYR48 |
| j | LMN101 |
| site_id | AD6 |
| Number of Residues | 8 |
| Details | binding site for residue SF4 K 301 |
| Chain | Residue |
| C | ARG141 |
| C | HIS226 |
| K | ALA84 |
| K | CYS85 |
| K | CYS86 |
| K | SER149 |
| K | CYS150 |
| K | CYS180 |
| site_id | AD7 |
| Number of Residues | 13 |
| Details | binding site for residue ZMP O 201 |
| Chain | Residue |
| O | SER66 |
| O | LEU67 |
| P | LEU21 |
| P | GLN22 |
| P | THR25 |
| P | GLU59 |
| P | PHE60 |
| P | HIS63 |
| P | ARG64 |
| P | GLN72 |
| P | LEU75 |
| P | GLY79 |
| P | GLU82 |
| site_id | AD8 |
| Number of Residues | 13 |
| Details | binding site for residue ZMP Q 201 |
| Chain | Residue |
| Q | SER89 |
| Q | LEU90 |
| R | PHE7 |
| R | ASN11 |
| R | SER22 |
| R | LYS46 |
| R | PHE47 |
| R | ASN50 |
| R | ALA51 |
| R | ILE53 |
| R | LEU59 |
| R | THR66 |
| R | HIS69 |
| site_id | AD9 |
| Number of Residues | 12 |
| Details | binding site for residue PLC W 401 |
| Chain | Residue |
| 1 | LEU183 |
| I | LYS76 |
| I | ALA81 |
| I | PHE84 |
| I | TYR88 |
| W | ALA25 |
| W | ARG26 |
| W | GLY27 |
| W | PHE28 |
| W | ARG29 |
| W | PRO30 |
| W | TYR33 |
| site_id | AE1 |
| Number of Residues | 8 |
| Details | binding site for residue PLC W 402 |
| Chain | Residue |
| 1 | PHE334 |
| W | GLY42 |
| W | PHE45 |
| W | TYR46 |
| W | LEU49 |
| W | GLY50 |
| W | GLN53 |
| g | TYR52 |
| site_id | AE2 |
| Number of Residues | 21 |
| Details | binding site for residue CDL X 201 |
| Chain | Residue |
| 1 | TYR332 |
| 2 | ILE3 |
| 3 | ASN85 |
| 3 | TYR86 |
| 3 | THR89 |
| 3 | LEU93 |
| 3 | LEU96 |
| 6 | PHE160 |
| 6 | LEU163 |
| 6 | VAL164 |
| X | SER129 |
| X | SER130 |
| X | PHE153 |
| X | PRO154 |
| X | TRP155 |
| X | PHE156 |
| X | PHE158 |
| X | VAL159 |
| X | ASN160 |
| g | PRO37 |
| g | CDL201 |
| site_id | AE3 |
| Number of Residues | 13 |
| Details | binding site for residue CDL g 201 |
| Chain | Residue |
| 2 | LEU4 |
| 2 | SER8 |
| 2 | THR11 |
| 2 | MET15 |
| X | LYS73 |
| X | ARG76 |
| X | VAL77 |
| X | PHE87 |
| X | CDL201 |
| g | PHE8 |
| g | TRP9 |
| g | TYR15 |
| g | 3PE202 |
| site_id | AE4 |
| Number of Residues | 13 |
| Details | binding site for residue 3PE g 202 |
| Chain | Residue |
| 1 | PRO318 |
| 3 | LEU96 |
| 3 | PHE102 |
| 3 | ILE106 |
| 3 | ASN107 |
| 3 | ASN109 |
| g | TYR15 |
| g | SER19 |
| g | ARG23 |
| g | LEU26 |
| g | PHE27 |
| g | PHE30 |
| g | CDL201 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue LMN j 101 |
| Chain | Residue |
| J | LEU114 |
| J | CDL204 |
| a | GLU34 |
| j | TYR48 |
| j | ARG50 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue PLC n 1101 |
| Chain | Residue |
| 4 | CYS467 |
| 4 | CDL502 |
| 5 | PHE65 |
| i | TYR51 |
| n | TYR35 |
| site_id | AE7 |
| Number of Residues | 15 |
| Details | binding site for residue T7X 2 501 |
| Chain | Residue |
| 2 | PHE74 |
| 2 | TYR85 |
| 2 | SER437 |
| 2 | VAL438 |
| 2 | TYR441 |
| 2 | SER445 |
| 2 | CPL502 |
| X | TRP59 |
| X | LEU60 |
| b | LYS18 |
| b | ARG25 |
| b | TYR32 |
| b | ALA42 |
| b | TRP43 |
| b | LEU46 |
| site_id | AE8 |
| Number of Residues | 12 |
| Details | binding site for residue CPL 2 502 |
| Chain | Residue |
| 2 | SER40 |
| 2 | TYR43 |
| 2 | TYR67 |
| 2 | PHE74 |
| 2 | TYR311 |
| 2 | THR314 |
| 2 | LEU378 |
| 2 | GLY453 |
| 2 | ILE460 |
| 2 | ILE463 |
| 2 | PHE464 |
| 2 | T7X501 |
| site_id | AE9 |
| Number of Residues | 10 |
| Details | binding site for residue T7X 2 503 |
| Chain | Residue |
| 2 | ILE166 |
| 2 | LEU199 |
| 2 | ILE202 |
| 2 | ASN256 |
| 2 | SER257 |
| 2 | LEU258 |
| 2 | VAL259 |
| 5 | VAL632 |
| 5 | LEU633 |
| L | PHE12 |
| site_id | AF1 |
| Number of Residues | 14 |
| Details | binding site for residue 3PE 4 501 |
| Chain | Residue |
| 2 | ALA358 |
| 2 | ILE366 |
| 2 | PHE369 |
| 2 | PRO376 |
| 4 | PHE14 |
| 4 | TYR28 |
| 4 | ASN110 |
| 4 | ASN112 |
| 4 | THR116 |
| 4 | LEU119 |
| 4 | ALA143 |
| 4 | LEU147 |
| 4 | ILE150 |
| 4 | 3PE503 |
| site_id | AF2 |
| Number of Residues | 23 |
| Details | binding site for residue CDL 4 502 |
| Chain | Residue |
| 4 | PHE337 |
| 4 | GLN371 |
| 4 | THR374 |
| 4 | TYR375 |
| 4 | LYS451 |
| 4 | PHE452 |
| 4 | ASN455 |
| 4 | ILE456 |
| 4 | ILE459 |
| 5 | LEU17 |
| 5 | PHE21 |
| 5 | 3PE901 |
| S | TYR169 |
| S | ALA173 |
| S | LEU176 |
| i | MET15 |
| i | TRP43 |
| n | TYR20 |
| n | LYS23 |
| n | TRP24 |
| n | VAL27 |
| n | SER28 |
| n | PLC1101 |
| site_id | AF3 |
| Number of Residues | 12 |
| Details | binding site for residue 3PE 4 503 |
| Chain | Residue |
| 2 | PHE452 |
| 2 | PHE454 |
| 4 | LEU3 |
| 4 | THR4 |
| 4 | PHE60 |
| 4 | ASN64 |
| 4 | PHE66 |
| 4 | GLY67 |
| 4 | LEU68 |
| 4 | 3PE501 |
| 4 | 3PE505 |
| b | THR5 |
| site_id | AF4 |
| Number of Residues | 12 |
| Details | binding site for residue T7X 4 504 |
| Chain | Residue |
| 2 | LEU411 |
| 4 | PHE165 |
| 4 | TYR166 |
| 4 | MET169 |
| 4 | PHE170 |
| 4 | SER173 |
| 4 | ILE227 |
| 5 | PRO589 |
| 5 | ILE592 |
| C | LEU37 |
| C | GLY38 |
| J | 3PE201 |
| site_id | AF5 |
| Number of Residues | 8 |
| Details | binding site for residue 3PE 4 505 |
| Chain | Residue |
| 4 | PHE38 |
| 4 | PHE55 |
| 4 | ASN56 |
| 4 | PHE57 |
| 4 | LEU126 |
| 4 | TRP130 |
| 4 | LEU140 |
| 4 | 3PE503 |
| site_id | AF6 |
| Number of Residues | 14 |
| Details | binding site for residue 3PE 5 901 |
| Chain | Residue |
| 4 | THR366 |
| 4 | THR367 |
| 4 | PRO370 |
| 4 | THR374 |
| 4 | ILE378 |
| 4 | CDL502 |
| 5 | TRP16 |
| 5 | HIS112 |
| 5 | ARG115 |
| 5 | LEU152 |
| i | SER14 |
| i | MET15 |
| i | THR16 |
| i | GLY18 |
| site_id | AF7 |
| Number of Residues | 8 |
| Details | binding site for residue PLC 5 902 |
| Chain | Residue |
| 5 | ILE296 |
| 5 | ASN299 |
| 5 | LYS431 |
| 5 | PHE536 |
| 5 | LEU538 |
| 5 | ASN544 |
| 5 | TYR547 |
| R | TRP29 |
| site_id | AF8 |
| Number of Residues | 12 |
| Details | binding site for residue 3PE 5 903 |
| Chain | Residue |
| 5 | GLN162 |
| 5 | LYS165 |
| 5 | SER166 |
| 5 | LEU168 |
| 5 | LEU172 |
| 5 | MET173 |
| 5 | PHE176 |
| 5 | GLY231 |
| 5 | LEU238 |
| 5 | ASN561 |
| 5 | ILE565 |
| a | ASP83 |
| site_id | AF9 |
| Number of Residues | 9 |
| Details | binding site for residue 3PE 6 301 |
| Chain | Residue |
| 1 | GLU101 |
| 1 | LEU102 |
| 1 | ASN103 |
| 1 | LEU104 |
| 3 | PHE4 |
| 6 | VAL41 |
| 6 | MET45 |
| 6 | TYR48 |
| 6 | LEU57 |
Functional Information from PROSITE/UniProt
| site_id | PS00012 |
| Number of Residues | 16 |
| Details | PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLNLDSLDTVEVVVAI |
| Chain | Residue | Details |
| O | ASP61-ILE76 | |
| Q | ASP84-ILE99 |
| site_id | PS00133 |
| Number of Residues | 11 |
| Details | CARBOXYPEPT_ZN_2 Zinc carboxypeptidases, zinc-binding region 2 signature. HSIAGLFiFPW |
| Chain | Residue | Details |
| X | HIS145-TRP155 |
| site_id | PS00198 |
| Number of Residues | 12 |
| Details | 4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaICP |
| Chain | Residue | Details |
| I | CYS130-PRO141 | |
| I | CYS169-PRO180 |
| site_id | PS00535 |
| Number of Residues | 12 |
| Details | COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK |
| Chain | Residue | Details |
| C | LEU119-LYS130 |
| site_id | PS00542 |
| Number of Residues | 22 |
| Details | COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREayDMYgvffegHpdlRrIM |
| Chain | Residue | Details |
| G | GLU179-MET200 |
| site_id | PS00641 |
| Number of Residues | 18 |
| Details | COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PryCYhdklaiaGnCRmC |
| Chain | Residue | Details |
| A | PRO66-CYS83 |
| site_id | PS00642 |
| Number of Residues | 13 |
| Details | COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPvCDqGGeCdLQ |
| Chain | Residue | Details |
| A | CYS133-GLN145 |
| site_id | PS00643 |
| Number of Residues | 11 |
| Details | COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIhCtRCVrF |
| Chain | Residue | Details |
| A | ARG182-PHE192 |
| site_id | PS00644 |
| Number of Residues | 16 |
| Details | COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GMGAYVCGEETSLIES |
| Chain | Residue | Details |
| B | GLY202-SER217 |
| site_id | PS00645 |
| Number of Residues | 12 |
| Details | COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG |
| Chain | Residue | Details |
| B | GLU379-GLY390 |
| site_id | PS00667 |
| Number of Residues | 16 |
| Details | COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQaFaDAVKLLlKE |
| Chain | Residue | Details |
| 1 | GLY46-GLU61 |
| site_id | PS00668 |
| Number of Residues | 14 |
| Details | COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLTESEseLVa.G |
| Chain | Residue | Details |
| 1 | PRO201-GLY214 |
| site_id | PS01099 |
| Number of Residues | 19 |
| Details | COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DnlFTlseveCLGaCvnAP |
| Chain | Residue | Details |
| H | ASP158-PRO176 |
| site_id | PS01150 |
| Number of Residues | 17 |
| Details | COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDVYvPgCPP |
| Chain | Residue | Details |
| K | GLY166-PRO182 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 320 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| 5 | ASN3-GLY23 | |
| 5 | ILE304-LEU322 | |
| 5 | LEU332-LEU354 | |
| 5 | LEU370-LEU390 | |
| 5 | VAL413-LEU433 | |
| 5 | ILE456-LEU476 | |
| 5 | ILE516-PHE536 | |
| 5 | LEU629-ILE649 | |
| 5 | MET34-LEU54 | |
| 5 | LEU84-ILE104 | |
| 5 | PHE116-TYR136 | |
| 5 | PHE137-TRP157 | |
| 5 | PHE180-ILE200 | |
| 5 | ALA204-MET224 | |
| 5 | THR244-LEU264 | |
| 5 | VAL276-ILE296 |
