6RCG

Crystal structure of Casein kinase 1 delta (CK1 delta) complexed with SR3029 inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue EDO A 301

Chain	Residue
A	HIS120
A	SER121
A	ARG192
A	TYR266
A	HOH454
A	HOH561

---

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO A 302

Chain	Residue
A	HOH410
A	PHE254
A	ASP265
A	TYR268

---

site_id	AC3
Number of Residues	20
Details	binding site for residue K0E A 303

Chain	Residue
A	ARG13
A	ILE15
A	GLY16
A	ILE23
A	ALA36
A	LYS38
A	TYR56
A	PRO66
A	MET82
A	GLU83
A	LEU84
A	LEU85
A	GLY86
A	LEU135
A	LYS217
A	ALA218
A	HOH414
A	HOH533
A	HOH596
A	HOH608

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGDIYlGtdiaagee..........VAIK

Chain	Residue	Details
A	ILE15-LYS38

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. FiHrDVKpdNFLM

Chain	Residue	Details
A	PHE124-MET136

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	268
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---