6RB7
Ruminococcus gnavus sialic acid aldolase catalytic lysine mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019262 | biological_process | N-acetylneuraminate catabolic process |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019262 | biological_process | N-acetylneuraminate catabolic process |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0005975 | biological_process | carbohydrate metabolic process |
| E | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
| E | 0016829 | molecular_function | lyase activity |
| E | 0019262 | biological_process | N-acetylneuraminate catabolic process |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0005975 | biological_process | carbohydrate metabolic process |
| F | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
| F | 0016829 | molecular_function | lyase activity |
| F | 0019262 | biological_process | N-acetylneuraminate catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue TRS A 401 |
| Chain | Residue |
| A | ASP194 |
| A | GLU195 |
| A | GLY211 |
| A | MET256 |
| A | TYR257 |
| A | HOH517 |
| A | HOH661 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | HOH517 |
| A | HOH745 |
| A | HOH779 |
| B | HOH836 |
| A | ASN255 |
| A | HOH515 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 403 |
| Chain | Residue |
| A | ARG236 |
| A | TYR240 |
| A | HOH502 |
| E | GLU206 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | GLU66 |
| A | MET69 |
| A | HOH556 |
| A | HOH718 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue BCN A 405 |
| Chain | Residue |
| A | ALA229 |
| A | GLY230 |
| A | HOH706 |
| E | GLY230 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue GOL A 406 |
| Chain | Residue |
| A | HIS114 |
| A | PRO142 |
| A | GLN143 |
| A | GLY146 |
| A | HOH503 |
| A | HOH519 |
| A | HOH752 |
| B | HIS114 |
| B | GLN143 |
| B | GLY146 |
| B | HOH544 |
| B | HOH708 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 407 |
| Chain | Residue |
| A | ASN255 |
| A | PRO280 |
| A | HOH677 |
| B | PRO116 |
| B | HOH769 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue TRS B 401 |
| Chain | Residue |
| B | ASP194 |
| B | GLU195 |
| B | GLY211 |
| B | THR212 |
| B | MET256 |
| B | TYR257 |
| B | HOH675 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 402 |
| Chain | Residue |
| A | HOH766 |
| B | ASN255 |
| B | HOH549 |
| B | HOH730 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 403 |
| Chain | Residue |
| A | PRO116 |
| A | HOH768 |
| B | ASN255 |
| B | PRO280 |
| B | HOH701 |
| site_id | AD2 |
| Number of Residues | 9 |
| Details | binding site for residue TRS E 401 |
| Chain | Residue |
| E | ASP194 |
| E | GLU195 |
| E | GLY211 |
| E | THR212 |
| E | MET256 |
| E | TYR257 |
| E | HOH516 |
| E | HOH638 |
| E | HOH829 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL E 402 |
| Chain | Residue |
| E | ASN255 |
| E | HOH516 |
| E | HOH726 |
| E | HOH736 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue MG E 403 |
| Chain | Residue |
| E | ASN255 |
| E | PRO280 |
| E | HOH693 |
| E | HOH736 |
| F | PRO116 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue TRS F 401 |
| Chain | Residue |
| F | ASP194 |
| F | GLU195 |
| F | GLY211 |
| F | MET256 |
| F | TYR257 |
| F | HOH676 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL F 402 |
| Chain | Residue |
| E | PHE113 |
| F | ASN255 |
| F | TYR257 |
| F | HOH516 |
| F | HOH732 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue PEG F 403 |
| Chain | Residue |
| F | GLY74 |
| F | LYS75 |
| F | HOH742 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue PEG F 404 |
| Chain | Residue |
| F | ARG236 |
| F | HOH513 |
| F | HOH601 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue MG F 405 |
| Chain | Residue |
| E | PRO116 |
| E | HOH764 |
| F | ASN255 |
| F | PRO280 |
| F | HOH647 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_01237","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Schiff-base intermediate with substrate","evidences":[{"source":"HAMAP-Rule","id":"MF_01237","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31636419","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RD1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
