Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003746 | molecular_function | translation elongation factor activity |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005853 | cellular_component | eukaryotic translation elongation factor 1 complex |
| A | 0006412 | biological_process | translation |
| A | 0006414 | biological_process | translational elongation |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003746 | molecular_function | translation elongation factor activity |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005853 | cellular_component | eukaryotic translation elongation factor 1 complex |
| B | 0006412 | biological_process | translation |
| B | 0006414 | biological_process | translational elongation |
| B | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue GPE A 501 |
| Chain | Residue |
| A | ALA373 |
| A | GLU374 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue GPE A 502 |
| Chain | Residue |
| A | THR242 |
| A | GLU301 |
| A | LEU303 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | binding site for residue GDP A 503 |
| Chain | Residue |
| A | LYS20 |
| A | SER21 |
| A | THR22 |
| A | SER53 |
| A | ASN153 |
| A | LYS154 |
| A | ASP156 |
| A | SER157 |
| A | SER194 |
| A | GLY195 |
| A | TRP196 |
| A | HOH612 |
| A | HOH613 |
| A | HOH621 |
| B | GLU203 |
| B | PRO204 |
| B | HOH619 |
| A | HIS15 |
| A | ASP17 |
| A | SER18 |
| A | GLY19 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | HIS349 |
| A | GLY351 |
| A | LYS395 |
| A | SER396 |
| B | GLU48 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue GOL A 505 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 506 |
| Chain | Residue |
| A | ASP380 |
| A | ARG381 |
| A | ARG382 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 507 |
| Chain | Residue |
| A | HIS15 |
| A | GLN132 |
| A | SO4510 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 508 |
| Chain | Residue |
| A | ARG69 |
| A | ARG381 |
| B | ARG69 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 509 |
| Chain | Residue |
| A | PRO160 |
| A | SER163 |
| A | GLU164 |
| A | LYS165 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 510 |
| Chain | Residue |
| A | HIS15 |
| A | ILE127 |
| A | SER128 |
| A | GLN132 |
| A | THR133 |
| A | SO4507 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue GPE B 501 |
| Chain | Residue |
| B | ALA373 |
| B | GLU374 |
| site_id | AD3 |
| Number of Residues | 15 |
| Details | binding site for residue GDP B 502 |
| Chain | Residue |
| B | ASP17 |
| B | SER18 |
| B | GLY19 |
| B | LYS20 |
| B | SER21 |
| B | THR22 |
| B | ASN153 |
| B | LYS154 |
| B | ASP156 |
| B | SER194 |
| B | GLY195 |
| B | TRP196 |
| B | LYS385 |
| B | GOL503 |
| B | HOH624 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 503 |
| Chain | Residue |
| B | TRP196 |
| B | HIS197 |
| B | LYS385 |
| B | LEU387 |
| B | GDP502 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 504 |
| Chain | Residue |
| B | GLN147 |
| B | LEU148 |
| B | ILE149 |
| B | THR187 |
| B | ARG218 |
| B | THR234 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 505 |
| Chain | Residue |
| B | TYR167 |
| B | PRO185 |
| B | VAL188 |
| B | PRO189 |
| B | PHE190 |
| B | TRP214 |
| B | LYS215 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 506 |
| Chain | Residue |
| A | VAL253 |
| A | TYR254 |
| A | LYS255 |
| B | ASP35 |
| B | LYS36 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 507 |
| Chain | Residue |
| B | ARG381 |
| B | HOH631 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 508 |
| Chain | Residue |
| A | LEU347 |
| A | ASN348 |
| B | ARG69 |
| B | ARG96 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 509 |
| Chain | Residue |
| B | LYS129 |
| B | ARG134 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 510 |
| Chain | Residue |
| B | PRO160 |
| B | SER163 |
| B | GLU164 |
| B | LYS165 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 511 |
| Chain | Residue |
| B | TYR141 |
| B | LYS146 |
| B | SER416 |
| B | GLN417 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 512 |
| Chain | Residue |
| B | SER53 |
| B | ARG381 |
| B | ARG382 |
Functional Information from PROSITE/UniProt
| site_id | PS00301 |
| Number of Residues | 16 |
| Details | G_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DKlkaEReRGITIdiS |
| Chain | Residue | Details |
| B | ASP61-SER76 | |
| A | ASP61-SER76 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 474 |
| Details | Domain: {"description":"tr-type G"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Region: {"description":"G1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Region: {"description":"G2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Region: {"description":"G3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Region: {"description":"G4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Region: {"description":"G5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25326326","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4C0S","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q05639","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6,N6-dimethyllysine","evidences":[{"source":"UniProtKB","id":"Q05639","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6,N6,N6-trimethyllysine","evidences":[{"source":"UniProtKB","id":"Q05639","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"25326326","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4C0S","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q05639","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P62632","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"25326326","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4C0S","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"5-glutamyl glycerylphosphorylethanolamine","evidences":[{"source":"PubMed","id":"9518480","evidenceCode":"ECO:0000269"}]} |
