Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6R8T

Crystal structure of aIF2gamma subunit I181T from archaeon Sulfolobus solfataricus complexed with GDPCP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0001731	biological_process	formation of translation preinitiation complex
A	0003743	molecular_function	translation initiation factor activity
A	0003746	molecular_function	translation elongation factor activity
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0006414	biological_process	translational elongation
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	29
Details	binding site for residue GCP A 501

Chain	Residue
A	VAL18
A	GLY96
A	ASN149
A	LYS150
A	ASP152
A	VAL153
A	SER184
A	ALA185
A	LEU186
A	MG502
A	FMT513
A	ASP19
A	HOH649
A	HOH653
A	HOH659
A	HOH661
A	HOH672
A	HOH696
A	HOH745
A	HOH809
A	HOH853
A	HOH934
A	HIS20
A	GLY21
A	LYS22
A	THR23
A	THR24
A	MET45
A	THR46

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 502

Chain	Residue
A	THR23
A	THR46
A	GCP501
A	HOH649
A	HOH659

site_id	AC3
Number of Residues	7
Details	binding site for residue FMT A 503

Chain	Residue
A	TYR206
A	ARG207
A	ASP208
A	GLN211
A	ILE243
A	HOH655
A	HOH673

site_id	AC4
Number of Residues	4
Details	binding site for residue FMT A 504

Chain	Residue
A	LEU312
A	SER364
A	THR365
A	HOH681

site_id	AC5
Number of Residues	5
Details	binding site for residue FMT A 505

Chain	Residue
A	GLN251
A	GLU252
A	GLU344
A	MET345
A	HOH750

site_id	AC6
Number of Residues	5
Details	binding site for residue FMT A 506

Chain	Residue
A	LEU105
A	SER360
A	VAL361
A	GLY362
A	HOH931

site_id	AC7
Number of Residues	5
Details	binding site for residue FMT A 507

Chain	Residue
A	ASP19
A	ARG43
A	GLY44
A	FMT523
A	HOH894

site_id	AC8
Number of Residues	5
Details	binding site for residue FMT A 508

Chain	Residue
A	ILE32
A	ALA52
A	GLU53
A	HOH815
A	HOH857

site_id	AC9
Number of Residues	4
Details	binding site for residue FMT A 509

Chain	Residue
A	PRO125
A	GLU252
A	HOH731
A	HOH899

site_id	AD1
Number of Residues	5
Details	binding site for residue FMT A 510

Chain	Residue
A	VAL223
A	VAL237
A	ARG280
A	HOH605
A	HOH624

site_id	AD2
Number of Residues	4
Details	binding site for residue FMT A 511

Chain	Residue
A	THR366
A	LEU367
A	ARG383
A	ARG384

site_id	AD3
Number of Residues	4
Details	binding site for residue FMT A 512

Chain	Residue
A	ARG130
A	HOH614
A	HOH823
A	HOH841

site_id	AD4
Number of Residues	10
Details	binding site for residue FMT A 513

Chain	Residue
A	ASP152
A	VAL153
A	HIS187
A	PRO324
A	LEU326
A	GCP501
A	HOH661
A	HOH798
A	HOH819
A	HOH903

site_id	AD5
Number of Residues	6
Details	binding site for residue FMT A 514

Chain	Residue
A	VAL58
A	LYS64
A	TYR68
A	LEU86
A	HOH643
A	HOH691

site_id	AD6
Number of Residues	1
Details	binding site for residue FMT A 515

Chain	Residue
A	TRP33

site_id	AD7
Number of Residues	4
Details	binding site for residue FMT A 516

Chain	Residue
A	PHE230
A	ASN231
A	HOH680
A	HOH820

site_id	AD8
Number of Residues	8
Details	binding site for residue FMT A 517

Chain	Residue
A	ARG130
A	ASP250
A	LYS275
A	VAL339
A	ALA342
A	HOH608
A	HOH614
A	HOH682

site_id	AD9
Number of Residues	5
Details	binding site for residue FMT A 518

Chain	Residue
A	LYS212
A	GLN244
A	TRP389
A	SER390
A	HOH800

site_id	AE1
Number of Residues	6
Details	binding site for residue FMT A 519

Chain	Residue
A	LYS347
A	VAL348
A	ASP349
A	ARG399
A	ILE401
A	HOH662

site_id	AE2
Number of Residues	3
Details	binding site for residue FMT A 520

Chain	Residue
A	THR365
A	HOH635
A	HOH636

site_id	AE3
Number of Residues	10
Details	binding site for residue FMT A 521

Chain	Residue
A	LYS234
A	GLY235
A	GLY236
A	VAL237
A	SER277
A	GLY298
A	THR299
A	HOH605
A	HOH740
A	HOH947

site_id	AE4
Number of Residues	5
Details	binding site for residue FMT A 522

Chain	Residue
A	GLY258
A	LEU259
A	ARG260
A	GLN264
A	ASN310

site_id	AE5
Number of Residues	5
Details	binding site for residue FMT A 523

Chain	Residue
A	ASP19
A	GLY44
A	FMT507
A	HOH620
A	HOH788

site_id	AE6
Number of Residues	2
Details	binding site for residue FMT A 524

Chain	Residue
A	LYS343
A	HOH712

site_id	AE7
Number of Residues	6
Details	binding site for residue FMT A 525

Chain	Residue
A	ALA342
A	ILE401
A	ARG404
A	ARG406
A	HOH633
A	HOH789

site_id	AE8
Number of Residues	6
Details	binding site for residue NA A 526

Chain	Residue
A	GLN168
A	PHE169
A	LYS171
A	HOH810
A	HOH970
A	HOH1078

site_id	AE9
Number of Residues	7
Details	binding site for residue NA A 527

Chain	Residue
A	MET111
A	HOH776
A	HOH781
A	HOH909
A	HOH1032
A	HOH1207
A	HOH1208

site_id	AF1
Number of Residues	6
Details	binding site for residue NA A 528

Chain	Residue
A	VAL151
A	VAL154
A	TRP327
A	ASN328
A	HOH916
A	HOH1101

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00119, ECO:0000269\|PubMed:25690901, ECO:0007744\|PDB:4RD1

Chain	Residue	Details
A	ASP19
A	GLY44

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00119, ECO:0000269\|PubMed:16407071, ECO:0000269\|PubMed:25690901, ECO:0007744\|PDB:2AHO

Chain	Residue	Details
A	THR23
A	THR46

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q8U082, ECO:0000255\|HAMAP-Rule:MF_00119

Chain	Residue	Details
A	CYS59
A	CYS62
A	CYS74
A	CYS77

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00119, ECO:0000269\|PubMed:25690901, ECO:0007744\|PDB:4RCY, ECO:0007744\|PDB:4RD1

Chain	Residue	Details
A	ASN149
A	SER184

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)