6R8S

Crystal structure of aIF2gamma subunit I181K from archaeon Sulfolobus solfataricus complexed with GDPCP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0001731	biological_process	formation of translation preinitiation complex
A	0003743	molecular_function	translation initiation factor activity
A	0003746	molecular_function	translation elongation factor activity
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0006414	biological_process	translational elongation
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	binding site for residue GCP A 501

Chain	Residue
A	VAL18
A	GLY96
A	ASN149
A	LYS150
A	ASP152
A	SER184
A	ALA185
A	LEU186
A	MG502
A	FMT508
A	HOH607
A	ASP19
A	HOH664
A	HOH672
A	HOH673
A	HOH676
A	HOH681
A	HOH703
A	HOH733
A	HOH749
A	HIS20
A	GLY21
A	LYS22
A	THR23
A	THR24
A	MET45
A	THR46

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 502

Chain	Residue
A	THR23
A	THR46
A	GCP501
A	HOH673
A	HOH681

---

site_id	AC3
Number of Residues	3
Details	binding site for residue FMT A 503

Chain	Residue
A	ARG130
A	HOH690
A	HOH821

---

site_id	AC4
Number of Residues	4
Details	binding site for residue FMT A 504

Chain	Residue
A	LEU312
A	SER364
A	THR365
A	HOH634

---

site_id	AC5
Number of Residues	5
Details	binding site for residue FMT A 505

Chain	Residue
A	GLN251
A	GLU252
A	GLU344
A	MET345
A	HOH637

---

site_id	AC6
Number of Residues	5
Details	binding site for residue FMT A 506

Chain	Residue
A	ILE32
A	ALA52
A	GLU53
A	HOH700
A	HOH807

---

site_id	AC7
Number of Residues	5
Details	binding site for residue FMT A 507

Chain	Residue
A	HIS37
A	ARG219
A	ASP309
A	HOH619
A	HOH633

---

site_id	AC8
Number of Residues	9
Details	binding site for residue FMT A 508

Chain	Residue
A	ASP152
A	VAL153
A	HIS187
A	PRO324
A	LEU326
A	GCP501
A	HOH699
A	HOH733
A	HOH738

---

site_id	AC9
Number of Residues	3
Details	binding site for residue FMT A 509

Chain	Residue
A	ARG43
A	MET45
A	HOH846

---

site_id	AD1
Number of Residues	4
Details	binding site for residue FMT A 510

Chain	Residue
A	THR366
A	LEU367
A	ARG383
A	ARG384

---

site_id	AD2
Number of Residues	3
Details	binding site for residue FMT A 511

Chain	Residue
A	THR365
A	HOH689
A	HOH828

---

site_id	AD3
Number of Residues	3
Details	binding site for residue FMT A 513

Chain	Residue
A	PRO125
A	GLU252
A	HOH773

---

site_id	AD4
Number of Residues	8
Details	binding site for residue FMT A 514

Chain	Residue
A	TRP33
A	SER35
A	GLU40
A	GLY44
A	MET45
A	THR46
A	HOH673
A	HOH884

---

site_id	AD5
Number of Residues	7
Details	binding site for residue FMT A 515

Chain	Residue
A	TYR206
A	ARG207
A	ASP208
A	GLN211
A	ILE243
A	HOH635
A	HOH662

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00119, ECO:0000269|PubMed:25690901, ECO:0007744|PDB:4RD1

Chain	Residue	Details
A	ASP19
A	GLY44

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00119, ECO:0000269|PubMed:16407071, ECO:0000269|PubMed:25690901, ECO:0007744|PDB:2AHO

Chain	Residue	Details
A	THR23
A	THR46

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q8U082, ECO:0000255|HAMAP-Rule:MF_00119

Chain	Residue	Details
A	CYS59
A	CYS62
A	CYS74
A	CYS77

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00119, ECO:0000269|PubMed:25690901, ECO:0007744|PDB:4RCY, ECO:0007744|PDB:4RD1

Chain	Residue	Details
A	ASN149
A	SER184

---