6R5D

Crystal structure of the Pri1 subunit of human primase bound to dATP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0000428	cellular_component	DNA-directed RNA polymerase complex
A	0003899	molecular_function	DNA-directed RNA polymerase activity
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005658	cellular_component	alpha DNA polymerase:primase complex
A	0006260	biological_process	DNA replication
A	0006269	biological_process	DNA replication, synthesis of primer
A	0006270	biological_process	DNA replication initiation
A	0008270	molecular_function	zinc ion binding
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0032553	molecular_function	ribonucleotide binding
A	0046872	molecular_function	metal ion binding
E	0000287	molecular_function	magnesium ion binding
E	0000428	cellular_component	DNA-directed RNA polymerase complex
E	0003899	molecular_function	DNA-directed RNA polymerase activity
E	0005515	molecular_function	protein binding
E	0005654	cellular_component	nucleoplasm
E	0005658	cellular_component	alpha DNA polymerase:primase complex
E	0006260	biological_process	DNA replication
E	0006269	biological_process	DNA replication, synthesis of primer
E	0006270	biological_process	DNA replication initiation
E	0008270	molecular_function	zinc ion binding
E	0016020	cellular_component	membrane
E	0016740	molecular_function	transferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0032553	molecular_function	ribonucleotide binding
E	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 501

Chain	Residue
A	CYS121
A	CYS122
A	CYS128
A	CYS131

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MN A 502

Chain	Residue
A	ASP109
A	ASP111
A	MN503
A	DTP504
A	HOH650

---

site_id	AC3
Number of Residues	7
Details	binding site for residue MN A 503

Chain	Residue
A	ASP109
A	ASP111
A	ASP306
A	MN502
A	DTP504
A	HOH696
A	HOH762

---

site_id	AC4
Number of Residues	16
Details	binding site for residue DTP A 504

Chain	Residue
A	ASP109
A	ASP111
A	SER160
A	ARG162
A	ARG163
A	HIS166
A	HIS315
A	LEU316
A	LEU317
A	LYS318
A	HIS324
A	MN502
A	MN503
A	HOH623
A	HOH650
A	HOH696

---

site_id	AC5
Number of Residues	6
Details	binding site for residue EDO A 505

Chain	Residue
A	THR349
A	SER351
E	ASP149
E	PHE150
E	TYR188
E	HOH648

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 506

Chain	Residue
A	ASP126
A	ILE127
A	EDO510
A	HOH642
E	SER173

---

site_id	AC7
Number of Residues	5
Details	binding site for residue EDO A 507

Chain	Residue
A	LYS153
A	HIS154
A	ARG155
A	ASN401
A	HOH660

---

site_id	AC8
Number of Residues	3
Details	binding site for residue EDO A 508

Chain	Residue
A	HOH630
A	HOH637
E	ARG355

---

site_id	AC9
Number of Residues	4
Details	binding site for residue EDO A 509

Chain	Residue
A	ASN217
A	LYS220
A	TRP294
E	ASP51

---

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO A 510

Chain	Residue
A	TYR159
A	ARG329
A	PRO344
A	EDO506

---

site_id	AD2
Number of Residues	2
Details	binding site for residue EDO A 511

Chain	Residue
A	ARG19
A	ARG381

---

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN E 501

Chain	Residue
E	CYS121
E	CYS122
E	CYS128
E	CYS131

---

site_id	AD4
Number of Residues	5
Details	binding site for residue MN E 502

Chain	Residue
E	ASP109
E	ASP111
E	MN503
E	DTP504
E	HOH699

---

site_id	AD5
Number of Residues	7
Details	binding site for residue MN E 503

Chain	Residue
E	ASP109
E	ASP111
E	ASP306
E	MN502
E	DTP504
E	HOH675
E	HOH688

---

site_id	AD6
Number of Residues	19
Details	binding site for residue DTP E 504

Chain	Residue
A	ARG278
E	TYR54
E	ASP79
E	ASP109
E	ASP111
E	SER160
E	ARG162
E	ARG163
E	HIS166
E	HIS315
E	LEU316
E	LEU317
E	LYS318
E	HIS324
E	MN502
E	MN503
E	HOH663
E	HOH675
E	HOH688

---

site_id	AD7
Number of Residues	3
Details	binding site for residue EDO E 505

Chain	Residue
A	SER173
E	ASP343
E	PHE345

---

site_id	AD8
Number of Residues	5
Details	binding site for residue EDO E 506

Chain	Residue
A	ASP149
A	PHE150
A	TYR188
E	THR349
E	SER351

---

site_id	AD9
Number of Residues	6
Details	binding site for residue EDO E 507

Chain	Residue
A	ILE360
E	LEU191
E	LYS201
E	VAL202
E	HIS203
E	HOH707

---

site_id	AE1
Number of Residues	4
Details	binding site for residue EDO E 508

Chain	Residue
E	PHE342
E	ASP343
E	THR346
E	TYR391

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Motif: {"description":"Zinc knuckle motif","evidences":[{"source":"PubMed","id":"24043831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25550159","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26975377","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24043831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31479243","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31479243","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6R4S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24043831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25550159","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26975377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31479243","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24043831","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24239947","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31479243","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31479243","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---