6R59
Crystal structure of PPEP-1(E143A/Y178F) in complex with substrate peptide Ac-EVAPPVP-NH2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 301 |
| Chain | Residue |
| A | HIS142 |
| A | HIS146 |
| A | GLU185 |
| E | PRO122 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 301 |
| Chain | Residue |
| B | HIS142 |
| B | HIS146 |
| B | GLU185 |
| C | PRO122 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide ACE C 118 and GLU C 119 |
| Chain | Residue |
| B | GLY118 |
| B | SER119 |
| B | HIS146 |
| B | HIS150 |
| C | VAL120 |
| B | THR30 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide VAL C 124 and LPD C 125 |
| Chain | Residue |
| A | GLU104 |
| A | GLY105 |
| B | GLY102 |
| B | TRP103 |
| B | HIS134 |
| B | ASP135 |
| B | ALA136 |
| B | HIS142 |
| B | ASN175 |
| B | PHE178 |
| B | HOH401 |
| C | PRO123 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide ACE E 118 and GLU E 119 |
| Chain | Residue |
| A | GLY118 |
| A | SER119 |
| A | HIS146 |
| A | HIS150 |
| A | GLN198 |
| A | HOH404 |
| A | HOH503 |
| E | VAL120 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide VAL E 124 and LPD E 125 |
| Chain | Residue |
| A | GLY102 |
| A | TRP103 |
| A | HIS134 |
| A | ASP135 |
| A | ALA136 |
| A | ASN175 |
| A | PHE178 |
| A | HOH418 |
| E | PRO123 |
| E | HOH201 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 370 |
| Details | Domain: {"description":"ATLF-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Region: {"description":"Interacts with substrate peptide","evidences":[{"source":"PubMed","id":"26211609","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24303041","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26211609","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26211609","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Site: {"description":"Interacts with substrate peptide","evidences":[{"source":"PubMed","id":"26211609","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"26211609","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
