6R58
Crystal structure of PPEP-1(E143A/Y178F/E184A) in complex with substrate peptide Ac-EVNAPVP-CONH2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0008237 | molecular_function | metallopeptidase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0006508 | biological_process | proteolysis |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0008237 | molecular_function | metallopeptidase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 300 |
| Chain | Residue |
| A | HIS142 |
| A | HIS146 |
| A | GLU185 |
| E | ALA4 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 B 301 |
| Chain | Residue |
| B | SER119 |
| B | HIS150 |
| F | ACE0 |
| F | GLU1 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 300 |
| Chain | Residue |
| C | HIS146 |
| C | GLU185 |
| I | ALA4 |
| C | HIS142 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 301 |
| Chain | Residue |
| D | HIS142 |
| D | HIS146 |
| D | GLU185 |
| G | ALA4 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue NI D 302 |
| Chain | Residue |
| D | GLY23 |
| D | SER24 |
| D | HIS25 |
| D | MET26 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide ACE E 0 and GLU E 1 |
| Chain | Residue |
| A | SER119 |
| A | HIS150 |
| A | HOH456 |
| E | VAL2 |
| E | ASN3 |
| E | HOH105 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for Di-peptide VAL E 6 and LPD E 7 |
| Chain | Residue |
| A | HIS134 |
| A | ASP135 |
| A | HIS142 |
| A | PHE178 |
| B | GLY105 |
| E | PRO5 |
| E | HOH101 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for Di-peptide ACE F 0 and GLU F 1 |
| Chain | Residue |
| B | GLY118 |
| B | SER119 |
| B | HIS150 |
| B | PO4301 |
| F | VAL2 |
| F | ASN3 |
| F | HOH102 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide VAL F 6 and LPD F 7 |
| Chain | Residue |
| B | GLY102 |
| B | HIS134 |
| B | ASP135 |
| B | ASN175 |
| B | PHE178 |
| F | PRO5 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide ACE G 0 and GLU G 1 |
| Chain | Residue |
| B | TYR94 |
| D | GLY118 |
| D | SER119 |
| D | HIS150 |
| G | VAL2 |
| G | ASN3 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for Di-peptide VAL G 6 and LPD G 7 |
| Chain | Residue |
| C | GLY105 |
| D | GLY102 |
| D | HIS134 |
| D | ASP135 |
| D | HIS142 |
| D | PHE178 |
| G | PRO5 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide ACE I 0 and GLU I 1 |
| Chain | Residue |
| A | THR30 |
| C | GLY118 |
| C | SER119 |
| C | HOH429 |
| I | VAL2 |
| I | ASN3 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for Di-peptide VAL I 6 and LPD I 7 |
| Chain | Residue |
| C | GLY102 |
| C | TRP103 |
| C | HIS134 |
| C | ASP135 |
| C | ALA136 |
| C | PHE178 |
| I | PRO5 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 740 |
| Details | Domain: {"description":"ATLF-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Region: {"description":"Interacts with substrate peptide","evidences":[{"source":"PubMed","id":"26211609","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24303041","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26211609","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26211609","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Site: {"description":"Interacts with substrate peptide","evidences":[{"source":"PubMed","id":"26211609","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"26211609","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
