6R51
Crystal structure of apo PPEP-1(E143A/Y178F) in complex with fibrinogen-derived substrate peptide Ac-SLRPAPP-CONH2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0008237 | molecular_function | metallopeptidase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 A 301 |
| Chain | Residue |
| A | HIS25 |
| A | TYR194 |
| A | HOH402 |
| A | HOH412 |
| A | HOH425 |
| A | HOH471 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide ACE D 31 and SER D 32 |
| Chain | Residue |
| D | LEU33 |
| D | ARG34 |
| D | HOH101 |
| F | ACE31 |
| F | SER32 |
| A | GLY117 |
| A | GLY118 |
| A | SER119 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide PRO D 37 and LPD D 38 |
| Chain | Residue |
| A | GLY102 |
| A | TRP103 |
| A | HIS134 |
| A | ASP135 |
| A | ALA136 |
| A | HIS142 |
| A | ASN175 |
| A | PHE178 |
| A | HOH513 |
| D | ALA36 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide ACE F 31 and SER F 32 |
| Chain | Residue |
| C | GLY117 |
| C | GLY118 |
| C | SER119 |
| C | HIS150 |
| D | ACE31 |
| D | SER32 |
| F | LEU33 |
| F | ARG34 |
| F | HOH102 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide PRO F 37 and LPD F 38 |
| Chain | Residue |
| C | GLY102 |
| C | TRP103 |
| C | HIS134 |
| C | ASP135 |
| C | ALA136 |
| C | HIS142 |
| C | PHE178 |
| F | ALA36 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 555 |
| Details | Domain: {"description":"ATLF-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Region: {"description":"Interacts with substrate peptide","evidences":[{"source":"PubMed","id":"26211609","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24303041","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26211609","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26211609","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Site: {"description":"Interacts with substrate peptide","evidences":[{"source":"PubMed","id":"26211609","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"26211609","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
