Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6R2N

Crystal structure of KlGlk1 glucokinase from Kluyveromyces lactis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001678	biological_process	intracellular glucose homeostasis
A	0004340	molecular_function	glucokinase activity
A	0004396	molecular_function	hexokinase activity
A	0005524	molecular_function	ATP binding
A	0005536	molecular_function	D-glucose binding
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0006006	biological_process	glucose metabolic process
A	0006091	biological_process	generation of precursor metabolites and energy
A	0006096	biological_process	glycolytic process
A	0008865	molecular_function	fructokinase activity
A	0016301	molecular_function	kinase activity
A	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
A	0019158	molecular_function	mannokinase activity
A	0019318	biological_process	hexose metabolic process
A	0019637	biological_process	organophosphate metabolic process
A	0046835	biological_process	carbohydrate phosphorylation
A	0051156	biological_process	glucose 6-phosphate metabolic process
A	1901135	biological_process	carbohydrate derivative metabolic process
B	0001678	biological_process	intracellular glucose homeostasis
B	0004340	molecular_function	glucokinase activity
B	0004396	molecular_function	hexokinase activity
B	0005524	molecular_function	ATP binding
B	0005536	molecular_function	D-glucose binding
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0006006	biological_process	glucose metabolic process
B	0006091	biological_process	generation of precursor metabolites and energy
B	0006096	biological_process	glycolytic process
B	0008865	molecular_function	fructokinase activity
B	0016301	molecular_function	kinase activity
B	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
B	0019158	molecular_function	mannokinase activity
B	0019318	biological_process	hexose metabolic process
B	0019637	biological_process	organophosphate metabolic process
B	0046835	biological_process	carbohydrate phosphorylation
B	0051156	biological_process	glucose 6-phosphate metabolic process
B	1901135	biological_process	carbohydrate derivative metabolic process
C	0001678	biological_process	intracellular glucose homeostasis
C	0004340	molecular_function	glucokinase activity
C	0004396	molecular_function	hexokinase activity
C	0005524	molecular_function	ATP binding
C	0005536	molecular_function	D-glucose binding
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0005975	biological_process	carbohydrate metabolic process
C	0006006	biological_process	glucose metabolic process
C	0006091	biological_process	generation of precursor metabolites and energy
C	0006096	biological_process	glycolytic process
C	0008865	molecular_function	fructokinase activity
C	0016301	molecular_function	kinase activity
C	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
C	0019158	molecular_function	mannokinase activity
C	0019318	biological_process	hexose metabolic process
C	0019637	biological_process	organophosphate metabolic process
C	0046835	biological_process	carbohydrate phosphorylation
C	0051156	biological_process	glucose 6-phosphate metabolic process
C	1901135	biological_process	carbohydrate derivative metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue EDO A 601

Chain	Residue
A	GLY235
A	THR236
A	EDO602

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO A 602

Chain	Residue
A	ASP428
A	LYS465
A	EDO601
A	HOH740

site_id	AC3
Number of Residues	3
Details	binding site for residue EDO A 603

Chain	Residue
A	THR133
A	HIS129
A	GLN130

site_id	AC4
Number of Residues	6
Details	binding site for residue EDO A 604

Chain	Residue
A	ASP220
A	GLN422
A	ARG439
A	ARG443
A	ARG462
A	EDO605

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 605

Chain	Residue
A	ILE225
A	GLN422
A	GLY437
A	SER440
A	EDO604

site_id	AC6
Number of Residues	4
Details	binding site for residue EDO A 606

Chain	Residue
A	THR71
A	HIS136
A	VAL139
A	HOH739

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO A 607

Chain	Residue
A	VAL59
A	THR60
A	ASP61
A	CYS475
A	HIS478
A	HOH706
A	HOH765

site_id	AC8
Number of Residues	2
Details	binding site for residue EDO A 608

Chain	Residue
A	ASP206
A	THR207

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO B 501

Chain	Residue
B	ASN205
B	ASP206
B	THR207
B	ASN239
B	EDO502

site_id	AD1
Number of Residues	6
Details	binding site for residue EDO B 502

Chain	Residue
B	ILE233
B	GLY237
B	THR238
B	ASN239
B	EDO501
B	EDO503

site_id	AD2
Number of Residues	3
Details	binding site for residue EDO B 503

Chain	Residue
B	THR236
B	GLY237
B	EDO502

site_id	AD3
Number of Residues	2
Details	binding site for residue BR C 501

Chain	Residue
B	GLU456
B	HOH603

Functional Information from PROSITE/UniProt

site_id	PS00378
Number of Residues	26
Details	HEXOKINASE_1 Hexokinase domain signature. MGFTFSYPvdqtsLSsgkLirWTKgF

Chain	Residue	Details
A	MET147-PHE172

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
A	THR106
A	GLY471
B	THR106
B	GLY471
C	THR106
C	GLY471

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)