Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6QSK

Crystal structure of a nucleotide sugar transporter with bound nucleotide monophosphate.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0005458	molecular_function	GDP-mannose transmembrane transporter activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0015297	molecular_function	antiporter activity
A	0030659	cellular_component	cytoplasmic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0055085	biological_process	transmembrane transport
A	1990570	biological_process	GDP-mannose transmembrane transport
B	0000139	cellular_component	Golgi membrane
B	0005458	molecular_function	GDP-mannose transmembrane transporter activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005794	cellular_component	Golgi apparatus
B	0015297	molecular_function	antiporter activity
B	0030659	cellular_component	cytoplasmic vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0055085	biological_process	transmembrane transport
B	1990570	biological_process	GDP-mannose transmembrane transport
C	0000139	cellular_component	Golgi membrane
C	0005458	molecular_function	GDP-mannose transmembrane transporter activity
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005794	cellular_component	Golgi apparatus
C	0015297	molecular_function	antiporter activity
C	0030659	cellular_component	cytoplasmic vesicle membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0055085	biological_process	transmembrane transport
C	1990570	biological_process	GDP-mannose transmembrane transport
D	0000139	cellular_component	Golgi membrane
D	0005458	molecular_function	GDP-mannose transmembrane transporter activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005794	cellular_component	Golgi apparatus
D	0015297	molecular_function	antiporter activity
D	0030659	cellular_component	cytoplasmic vesicle membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0055085	biological_process	transmembrane transport
D	1990570	biological_process	GDP-mannose transmembrane transport
E	0000139	cellular_component	Golgi membrane
E	0005458	molecular_function	GDP-mannose transmembrane transporter activity
E	0005515	molecular_function	protein binding
E	0005739	cellular_component	mitochondrion
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005794	cellular_component	Golgi apparatus
E	0015297	molecular_function	antiporter activity
E	0030659	cellular_component	cytoplasmic vesicle membrane
E	0031410	cellular_component	cytoplasmic vesicle
E	0055085	biological_process	transmembrane transport
E	1990570	biological_process	GDP-mannose transmembrane transport
F	0000139	cellular_component	Golgi membrane
F	0005458	molecular_function	GDP-mannose transmembrane transporter activity
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005794	cellular_component	Golgi apparatus
F	0015297	molecular_function	antiporter activity
F	0030659	cellular_component	cytoplasmic vesicle membrane
F	0031410	cellular_component	cytoplasmic vesicle
F	0055085	biological_process	transmembrane transport
F	1990570	biological_process	GDP-mannose transmembrane transport
G	0000139	cellular_component	Golgi membrane
G	0005458	molecular_function	GDP-mannose transmembrane transporter activity
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005794	cellular_component	Golgi apparatus
G	0015297	molecular_function	antiporter activity
G	0030659	cellular_component	cytoplasmic vesicle membrane
G	0031410	cellular_component	cytoplasmic vesicle
G	0055085	biological_process	transmembrane transport
G	1990570	biological_process	GDP-mannose transmembrane transport
H	0000139	cellular_component	Golgi membrane
H	0005458	molecular_function	GDP-mannose transmembrane transporter activity
H	0005515	molecular_function	protein binding
H	0005739	cellular_component	mitochondrion
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0005794	cellular_component	Golgi apparatus
H	0015297	molecular_function	antiporter activity
H	0030659	cellular_component	cytoplasmic vesicle membrane
H	0031410	cellular_component	cytoplasmic vesicle
H	0055085	biological_process	transmembrane transport
H	1990570	biological_process	GDP-mannose transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue OLC A 401

Chain	Residue
A	TYR127
A	VAL137
E	MET140
E	LEU310
E	LYS328

site_id	AC2
Number of Residues	6
Details	binding site for residue 5GP C 401

Chain	Residue
C	SER266
C	TYR281
C	TYR28
C	LEU95
C	SER262
C	ILE265

site_id	AC3
Number of Residues	7
Details	binding site for residue 5GP D 401

Chain	Residue
D	TYR28
D	MET98
D	SER262
D	SER269
D	TYR281
D	GLY285
D	LYS289

site_id	AC4
Number of Residues	3
Details	binding site for residue NA D 402

Chain	Residue
D	TYR28
D	TYR281
D	GLY285

site_id	AC5
Number of Residues	4
Details	binding site for residue 5GP E 401

Chain	Residue
E	MET35
E	ILE265
E	SER269
E	TYR281

site_id	AC6
Number of Residues	5
Details	binding site for residue OLC E 402

Chain	Residue
A	MET140
E	TYR127
E	VAL137
E	LEU142
E	VAL149

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	288
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1260
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	168
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	96
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	32
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)