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6QQV

Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0002939biological_processtRNA N1-guanine methylation
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006400biological_processtRNA modification
A0008033biological_processtRNA processing
A0008168molecular_functionmethyltransferase activity
A0032259biological_processmethylation
A0052906molecular_functiontRNA (guanine(37)-N1)-methyltransferase activity
B0002939biological_processtRNA N1-guanine methylation
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006400biological_processtRNA modification
B0008033biological_processtRNA processing
B0008168molecular_functionmethyltransferase activity
B0032259biological_processmethylation
B0052906molecular_functiontRNA (guanine(37)-N1)-methyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues17
Detailsbinding site for residue JEW A 301
ChainResidue
APRO83
AILE133
AGLY134
ATYR136
ALEU138
AASN139
AGLY140
AGLY141
AHOH514
ATHR84
APRO85
AGLY109
AARG110
ATYR111
AGLU112
AGLY113
ASER132

site_idAC2
Number of Residues9
Detailsbinding site for residue SO4 B 301
ChainResidue
AALA123
AARG125
AMET126
ATHR185
AARG186
BASP50
BSER51
BTYR53
BHOH404

site_idAC3
Number of Residues3
Detailsbinding site for residue SO4 B 302
ChainResidue
BARG127
BARG129
BHOH407

site_idAC4
Number of Residues17
Detailsbinding site for residue JEW B 303
ChainResidue
BPRO83
BTHR84
BPRO85
BGLY109
BARG110
BTYR111
BGLU112
BGLY113
BSER132
BILE133
BGLY134
BTYR136
BVAL137
BLEU138
BGLY140
BGLY141
BHOH472

Functional Information from PROSITE/UniProt
site_idPS00430
Number of Residues86
DetailsTONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. gsmkidvvtifpeylqpvrqslpgkaidaglvdvavhdlrrwthdvhksvddspygggpgmvmkptvwgdaldeicts.....................................ETLLVVPT
ChainResidueDetails
AGLY-1-THR84

227111

PDB entries from 2024-11-06

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