6QMO

Death-associated Protein Kinase 1 (DAPK1) catalytic and auto-regulatory domains with S289E and S308A mutations

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue GOL A 401

Chain	Residue
A	LYS46
A	ARG48
A	LYS86
A	GLU224
A	ASN228
A	ASN233

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site_id	AC2
Number of Residues	5
Details	binding site for residue GOL A 402

Chain	Residue
A	ILE188
A	TYR191
A	ILE177
A	PHE178
A	GLY179

---

site_id	AC3
Number of Residues	4
Details	binding site for residue GOL A 403

Chain	Residue
A	ASN75
A	GLN122
A	ASN125
A	HOH511

---

site_id	AC4
Number of Residues	7
Details	binding site for residue GOL A 404

Chain	Residue
A	GLN38
A	TYR39
A	GLU94
A	LEU95
A	SER132
A	HOH506
A	HOH530

---

site_id	AC5
Number of Residues	6
Details	binding site for residue GOL A 405

Chain	Residue
A	ALA40
A	ILE77
A	GLU94
A	LEU95
A	VAL96
A	ILE160

---

site_id	AC6
Number of Residues	6
Details	binding site for residue GOL A 406

Chain	Residue
A	ARG5
A	TYR12
A	GLU32
A	SER34
A	GLN271
A	HOH558

---

site_id	AC7
Number of Residues	3
Details	binding site for residue CL A 407

Chain	Residue
A	LYS42
A	GLU64
A	HOH522

---

site_id	AC8
Number of Residues	1
Details	binding site for residue CL A 408

Chain	Residue
A	ARG263

---

site_id	AC9
Number of Residues	2
Details	binding site for residue CL A 409

Chain	Residue
A	GLU235
A	ARG253

---

site_id	AD1
Number of Residues	1
Details	binding site for residue CL A 410

Chain	Residue
A	HOH593

---

site_id	AD2
Number of Residues	2
Details	binding site for residue CL A 411

Chain	Residue
A	GLU100
A	ASP103

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site_id	AD3
Number of Residues	7
Details	binding site for residue PGE A 412

Chain	Residue
A	HIS80
A	HIS131
A	SER132
A	GLN134
A	LEU196
A	ILE266
A	GLN267

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	28
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGQFAVVKkCrekstglqyaak......FIKK

Chain	Residue	Details
A	LEU19-LYS46

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHfDLKpeNIML

Chain	Residue	Details
A	ILE135-LEU147

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP139

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING:

Chain	Residue	Details
A	LEU19
A	LYS42
A	GLU94
A	GLU100
A	ASP161

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by RPS6KA1 and RPS6KA3 => ECO:0000269|PubMed:16213824

Chain	Residue	Details
A	GLU289

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:11579085, ECO:0000269|PubMed:15729359, ECO:0000269|PubMed:17056602

Chain	Residue	Details
A	ALA308

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