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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6QLD

Structure of inner kinetochore CCAN-Cenp-A complex

Functional Information from GO Data
ChainGOidnamespacecontents
L0000776cellular_componentkinetochore
L0000940cellular_componentouter kinetochore
L0003674molecular_functionmolecular_function
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0007059biological_processchromosome segregation
L0008608biological_processattachment of spindle microtubules to kinetochore
L0030437biological_processascospore formation
L0034087biological_processestablishment of mitotic sister chromatid cohesion
L0034089biological_processestablishment of meiotic sister chromatid cohesion
L0034090biological_processmaintenance of meiotic sister chromatid cohesion
L0045144biological_processmeiotic sister chromatid segregation
L0051301biological_processcell division
L0051321biological_processmeiotic cell cycle
L0071459biological_processprotein localization to chromosome, centromeric region
N0000776cellular_componentkinetochore
N0000940cellular_componentouter kinetochore
N0005198molecular_functionstructural molecule activity
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0007059biological_processchromosome segregation
N0007094biological_processmitotic spindle assembly checkpoint signaling
N0008608biological_processattachment of spindle microtubules to kinetochore
N0034080biological_processCENP-A containing chromatin assembly
N0034087biological_processestablishment of mitotic sister chromatid cohesion
N0034089biological_processestablishment of meiotic sister chromatid cohesion
N0034090biological_processmaintenance of meiotic sister chromatid cohesion
N0051301biological_processcell division
N0051321biological_processmeiotic cell cycle
N0051382biological_processkinetochore assembly
N0071459biological_processprotein localization to chromosome, centromeric region
O0000776cellular_componentkinetochore
O0051382biological_processkinetochore assembly
Y0000776cellular_componentkinetochore
Y0003674molecular_functionmolecular_function
Y0005515molecular_functionprotein binding
Y0005634cellular_componentnucleus
Y0007059biological_processchromosome segregation
Y0008150biological_processbiological_process
Y0008608biological_processattachment of spindle microtubules to kinetochore
Y0051301biological_processcell division
Y0051321biological_processmeiotic cell cycle
Z0000776cellular_componentkinetochore
Z0003674molecular_functionmolecular_function
Z0005515molecular_functionprotein binding
Z0005634cellular_componentnucleus
Z0007059biological_processchromosome segregation
Z0008608biological_processattachment of spindle microtubules to kinetochore
Z0031511cellular_componentMis6-Sim4 complex
Z0051301biological_processcell division
Z0051321biological_processmeiotic cell cycle
a0000786cellular_componentnucleosome
a0003677molecular_functionDNA binding
a0030527molecular_functionstructural constituent of chromatin
a0046982molecular_functionprotein heterodimerization activity
b0003677molecular_functionDNA binding
b0030527molecular_functionstructural constituent of chromatin
b0046982molecular_functionprotein heterodimerization activity
d0000786cellular_componentnucleosome
d0003677molecular_functionDNA binding
d0030527molecular_functionstructural constituent of chromatin
d0046982molecular_functionprotein heterodimerization activity
e0000786cellular_componentnucleosome
e0003677molecular_functionDNA binding
e0030527molecular_functionstructural constituent of chromatin
e0046982molecular_functionprotein heterodimerization activity
f0003677molecular_functionDNA binding
f0030527molecular_functionstructural constituent of chromatin
f0046982molecular_functionprotein heterodimerization activity
g0000786cellular_componentnucleosome
g0003677molecular_functionDNA binding
g0030527molecular_functionstructural constituent of chromatin
g0046982molecular_functionprotein heterodimerization activity
h0000786cellular_componentnucleosome
h0003677molecular_functionDNA binding
h0030527molecular_functionstructural constituent of chromatin
h0046982molecular_functionprotein heterodimerization activity
i0000786cellular_componentnucleosome
i0003677molecular_functionDNA binding
i0030527molecular_functionstructural constituent of chromatin
i0046982molecular_functionprotein heterodimerization activity
Functional Information from PROSITE/UniProt
site_idPS00014
Number of Residues4
DetailsER_TARGET Endoplasmic reticulum targeting sequence. SNEL
ChainResidueDetails
USER317-LEU320
site_idPS00046
Number of Residues7
DetailsHISTONE_H2A Histone H2A signature. AGLtFPV
ChainResidueDetails
iALA23-VAL29
gALA23-VAL29
site_idPS00357
Number of Residues23
DetailsHISTONE_H2B Histone H2B signature. REIQTavRlILpGELaKHAVSEG
ChainResidueDetails
dARG96-GLY118
hARG96-GLY118
site_idPS00959
Number of Residues9
DetailsHISTONE_H3_2 Histone H3 signature 2. PFaRLVKEV
ChainResidueDetails
ePRO157-VAL165
aPRO157-VAL165
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues152
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues8
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"19113941","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"16768447","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"N6-glutaryllysine","evidences":[{"source":"PubMed","id":"31542297","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"N6,N6-dimethyllysine","evidences":[{"source":"PubMed","id":"19113941","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"12535538","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12535539","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14660635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15280549","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsSite: {"description":"Not ubiquitinated","evidences":[{"source":"PubMed","id":"10642555","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2201907","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"N5-methylglutamine","evidences":[{"source":"PubMed","id":"24352239","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"N6-malonyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"10642555","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12535538","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12535539","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14660635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15280549","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16432255","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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