6QL5

Structure of fatty acid synthase complex with bound gamma subunit from Saccharomyces cerevisiae at 2.8 angstrom

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004312	molecular_function	fatty acid synthase activity
A	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
A	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A	0004321	molecular_function	fatty-acyl-CoA synthase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005835	cellular_component	fatty acid synthase complex
A	0006633	biological_process	fatty acid biosynthetic process
A	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0042759	biological_process	long-chain fatty acid biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0004312	molecular_function	fatty acid synthase activity
B	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
B	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B	0004321	molecular_function	fatty-acyl-CoA synthase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005835	cellular_component	fatty acid synthase complex
B	0006633	biological_process	fatty acid biosynthetic process
B	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
B	0016491	molecular_function	oxidoreductase activity
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0042759	biological_process	long-chain fatty acid biosynthetic process
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0004312	molecular_function	fatty acid synthase activity
C	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
C	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
C	0004321	molecular_function	fatty-acyl-CoA synthase activity
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0005835	cellular_component	fatty acid synthase complex
C	0006633	biological_process	fatty acid biosynthetic process
C	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
C	0016491	molecular_function	oxidoreductase activity
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0042759	biological_process	long-chain fatty acid biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0004312	molecular_function	fatty acid synthase activity
D	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
D	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
D	0004321	molecular_function	fatty-acyl-CoA synthase activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0005835	cellular_component	fatty acid synthase complex
D	0006633	biological_process	fatty acid biosynthetic process
D	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
D	0016491	molecular_function	oxidoreductase activity
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0042759	biological_process	long-chain fatty acid biosynthetic process
D	0046872	molecular_function	metal ion binding
E	0000287	molecular_function	magnesium ion binding
E	0004312	molecular_function	fatty acid synthase activity
E	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
E	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
E	0004321	molecular_function	fatty-acyl-CoA synthase activity
E	0005515	molecular_function	protein binding
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0005835	cellular_component	fatty acid synthase complex
E	0006633	biological_process	fatty acid biosynthetic process
E	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
E	0016491	molecular_function	oxidoreductase activity
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0042759	biological_process	long-chain fatty acid biosynthetic process
E	0046872	molecular_function	metal ion binding
F	0000287	molecular_function	magnesium ion binding
F	0004312	molecular_function	fatty acid synthase activity
F	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
F	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
F	0004321	molecular_function	fatty-acyl-CoA synthase activity
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0005835	cellular_component	fatty acid synthase complex
F	0006633	biological_process	fatty acid biosynthetic process
F	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
F	0016491	molecular_function	oxidoreductase activity
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0042759	biological_process	long-chain fatty acid biosynthetic process
F	0046872	molecular_function	metal ion binding
G	0004312	molecular_function	fatty acid synthase activity
G	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
G	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
G	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G	0004321	molecular_function	fatty-acyl-CoA synthase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005811	cellular_component	lipid droplet
G	0005829	cellular_component	cytosol
G	0005835	cellular_component	fatty acid synthase complex
G	0006633	biological_process	fatty acid biosynthetic process
G	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
G	0016409	molecular_function	palmitoyltransferase activity
G	0016491	molecular_function	oxidoreductase activity
G	0016740	molecular_function	transferase activity
G	0016787	molecular_function	hydrolase activity
G	0016829	molecular_function	lyase activity
G	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
G	0042759	biological_process	long-chain fatty acid biosynthetic process
G	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
H	0004312	molecular_function	fatty acid synthase activity
H	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
H	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
H	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H	0004321	molecular_function	fatty-acyl-CoA synthase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005811	cellular_component	lipid droplet
H	0005829	cellular_component	cytosol
H	0005835	cellular_component	fatty acid synthase complex
H	0006633	biological_process	fatty acid biosynthetic process
H	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
H	0016409	molecular_function	palmitoyltransferase activity
H	0016491	molecular_function	oxidoreductase activity
H	0016740	molecular_function	transferase activity
H	0016787	molecular_function	hydrolase activity
H	0016829	molecular_function	lyase activity
H	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
H	0042759	biological_process	long-chain fatty acid biosynthetic process
H	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
I	0004312	molecular_function	fatty acid synthase activity
I	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
I	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
I	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I	0004321	molecular_function	fatty-acyl-CoA synthase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005811	cellular_component	lipid droplet
I	0005829	cellular_component	cytosol
I	0005835	cellular_component	fatty acid synthase complex
I	0006633	biological_process	fatty acid biosynthetic process
I	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
I	0016409	molecular_function	palmitoyltransferase activity
I	0016491	molecular_function	oxidoreductase activity
I	0016740	molecular_function	transferase activity
I	0016787	molecular_function	hydrolase activity
I	0016829	molecular_function	lyase activity
I	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
I	0042759	biological_process	long-chain fatty acid biosynthetic process
I	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
J	0004312	molecular_function	fatty acid synthase activity
J	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
J	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
J	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J	0004321	molecular_function	fatty-acyl-CoA synthase activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005811	cellular_component	lipid droplet
J	0005829	cellular_component	cytosol
J	0005835	cellular_component	fatty acid synthase complex
J	0006633	biological_process	fatty acid biosynthetic process
J	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
J	0016409	molecular_function	palmitoyltransferase activity
J	0016491	molecular_function	oxidoreductase activity
J	0016740	molecular_function	transferase activity
J	0016787	molecular_function	hydrolase activity
J	0016829	molecular_function	lyase activity
J	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
J	0042759	biological_process	long-chain fatty acid biosynthetic process
J	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
K	0004312	molecular_function	fatty acid synthase activity
K	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
K	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
K	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K	0004321	molecular_function	fatty-acyl-CoA synthase activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005811	cellular_component	lipid droplet
K	0005829	cellular_component	cytosol
K	0005835	cellular_component	fatty acid synthase complex
K	0006633	biological_process	fatty acid biosynthetic process
K	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
K	0016409	molecular_function	palmitoyltransferase activity
K	0016491	molecular_function	oxidoreductase activity
K	0016740	molecular_function	transferase activity
K	0016787	molecular_function	hydrolase activity
K	0016829	molecular_function	lyase activity
K	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
K	0042759	biological_process	long-chain fatty acid biosynthetic process
K	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
L	0004312	molecular_function	fatty acid synthase activity
L	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
L	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
L	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L	0004321	molecular_function	fatty-acyl-CoA synthase activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005811	cellular_component	lipid droplet
L	0005829	cellular_component	cytosol
L	0005835	cellular_component	fatty acid synthase complex
L	0006633	biological_process	fatty acid biosynthetic process
L	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
L	0016409	molecular_function	palmitoyltransferase activity
L	0016491	molecular_function	oxidoreductase activity
L	0016740	molecular_function	transferase activity
L	0016787	molecular_function	hydrolase activity
L	0016829	molecular_function	lyase activity
L	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
L	0042759	biological_process	long-chain fatty acid biosynthetic process
L	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005835	cellular_component	fatty acid synthase complex
M	0006633	biological_process	fatty acid biosynthetic process
M	0030674	molecular_function	protein-macromolecule adaptor activity
M	0070682	biological_process	proteasome regulatory particle assembly
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005835	cellular_component	fatty acid synthase complex
N	0006633	biological_process	fatty acid biosynthetic process
N	0030674	molecular_function	protein-macromolecule adaptor activity
N	0070682	biological_process	proteasome regulatory particle assembly
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005835	cellular_component	fatty acid synthase complex
O	0006633	biological_process	fatty acid biosynthetic process
O	0030674	molecular_function	protein-macromolecule adaptor activity
O	0070682	biological_process	proteasome regulatory particle assembly
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0005835	cellular_component	fatty acid synthase complex
P	0006633	biological_process	fatty acid biosynthetic process
P	0030674	molecular_function	protein-macromolecule adaptor activity
P	0070682	biological_process	proteasome regulatory particle assembly
Q	0005634	cellular_component	nucleus
Q	0005737	cellular_component	cytoplasm
Q	0005835	cellular_component	fatty acid synthase complex
Q	0006633	biological_process	fatty acid biosynthetic process
Q	0030674	molecular_function	protein-macromolecule adaptor activity
Q	0070682	biological_process	proteasome regulatory particle assembly
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0005835	cellular_component	fatty acid synthase complex
R	0006633	biological_process	fatty acid biosynthetic process
R	0030674	molecular_function	protein-macromolecule adaptor activity
R	0070682	biological_process	proteasome regulatory particle assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue PNS A 1901

Chain	Residue
A	SER180
I	SER510
I	GLN163
I	GLY164
I	ASN165
I	HIS273
I	SER274
I	MET338
I	LEU370
I	ASN372

---

site_id	AC2
Number of Residues	10
Details	binding site for residue PNS B 1901

Chain	Residue
B	SER180
G	GLN163
G	GLY164
G	ASN165
G	HIS273
G	SER274
G	MET338
G	LEU370
G	ASN372
G	SER510

---

site_id	AC3
Number of Residues	10
Details	binding site for residue PNS C 1901

Chain	Residue
C	SER180
H	GLN163
H	GLY164
H	ASN165
H	HIS273
H	SER274
H	MET338
H	LEU370
H	ASN372
H	SER510

---

site_id	AC4
Number of Residues	16
Details	binding site for residue FMN G 2101

Chain	Residue
G	PRO595
G	GLY596
G	MET597
G	THR598
G	ASN650
G	GLY682
G	LYS706
G	THR733
G	GLY737
G	GLY738
G	SER769
G	GLY770
G	GLY802
G	SER803
G	LEU1054
G	ALA1059

---

site_id	AC5
Number of Residues	16
Details	binding site for residue FMN H 2101

Chain	Residue
H	PRO595
H	GLY596
H	MET597
H	THR598
H	ASN650
H	GLY682
H	LYS706
H	THR733
H	GLY737
H	GLY738
H	SER769
H	GLY770
H	GLY802
H	SER803
H	LEU1054
H	ALA1059

---

site_id	AC6
Number of Residues	16
Details	binding site for residue FMN I 2101

Chain	Residue
I	PRO595
I	GLY596
I	MET597
I	THR598
I	ASN650
I	GLY682
I	LYS706
I	THR733
I	GLY737
I	GLY738
I	SER769
I	GLY770
I	GLY802
I	SER803
I	LEU1054
I	ALA1059

---

site_id	AC7
Number of Residues	16
Details	binding site for residue FMN J 2101

Chain	Residue
J	PRO595
J	GLY596
J	MET597
J	THR598
J	ASN650
J	GLY682
J	LYS706
J	THR733
J	GLY737
J	GLY738
J	SER769
J	GLY770
J	GLY802
J	SER803
J	LEU1054
J	ALA1059

---

site_id	AC8
Number of Residues	16
Details	binding site for residue FMN K 2101

Chain	Residue
K	GLY682
K	LYS706
K	THR733
K	GLY737
K	GLY738
K	SER769
K	GLY770
K	GLY802
K	SER803
K	LEU1054
K	ALA1059
K	PRO595
K	GLY596
K	MET597
K	THR598
K	ASN650

---

site_id	AC9
Number of Residues	16
Details	binding site for residue FMN L 2101

Chain	Residue
L	PRO595
L	GLY596
L	MET597
L	THR598
L	ASN650
L	GLY682
L	LYS706
L	THR733
L	GLY737
L	GLY738
L	SER769
L	GLY770
L	GLY802
L	SER803
L	LEU1054
L	ALA1059

---

site_id	AD1
Number of Residues	15
Details	binding site for Di-peptide PNS D 1901 and SER D 180

Chain	Residue
D	GLY178
D	LYS179
D	THR181
D	VAL182
D	GLN183
D	ASN184
L	GLN163
L	GLY164
L	ASN165
L	HIS273
L	SER274
L	MET338
L	LEU370
L	ASN372
L	SER510

---

site_id	AD2
Number of Residues	15
Details	binding site for Di-peptide PNS E 1901 and SER E 180

Chain	Residue
E	GLY178
E	LYS179
E	THR181
E	VAL182
E	GLN183
E	ASN184
J	GLN163
J	GLY164
J	ASN165
J	HIS273
J	SER274
J	MET338
J	LEU370
J	ASN372
J	SER510

---

site_id	AD3
Number of Residues	15
Details	binding site for Di-peptide PNS F 1901 and SER F 180

Chain	Residue
F	GLY178
F	LYS179
F	THR181
F	VAL182
F	GLN183
F	ASN184
K	GLN163
K	GLY164
K	ASN165
K	HIS273
K	SER274
K	MET338
K	LEU370
K	ASN372
K	SER510

---

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. LVGGKSTVQNEILGDL

Chain	Residue	Details
A	LEU175-LEU190

---

site_id	PS00606
Number of Residues	17
Details	KS3_1 Ketosynthase family 3 (KS3) active site signature. GPIktPVgACATSveSV

Chain	Residue	Details
A	GLY1296-VAL1312

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
M	SER24
D	CYS1305
D	HIS1542
D	HIS1583
E	CYS1305
E	HIS1542
E	HIS1583
F	CYS1305
F	HIS1542
F	HIS1583
N	SER24
O	SER24
P	SER24
Q	SER24
R	SER24
C	CYS1305
C	HIS1542
C	HIS1583

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
M	SER68
B	VAL1773
B	GLU1774
B	GLU1817
B	ARG1841
B	ILE1871
B	SER1872
B	HIS1873
C	ASP1772
C	VAL1773
C	GLU1774
N	SER68
C	GLU1817
C	ARG1841
C	ILE1871
C	SER1872
C	HIS1873
D	ASP1772
D	VAL1773
D	GLU1774
D	GLU1817
D	ARG1841
O	SER68
D	ILE1871
D	SER1872
D	HIS1873
E	ASP1772
E	VAL1773
E	GLU1774
E	GLU1817
E	ARG1841
E	ILE1871
E	SER1872
P	SER68
E	HIS1873
F	ASP1772
F	VAL1773
F	GLU1774
F	GLU1817
F	ARG1841
F	ILE1871
F	SER1872
F	HIS1873
Q	SER68
R	SER68
A	SER1872
A	HIS1873
B	ASP1772

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
G	THR733
E	SER1808
F	TYR1798
F	SER1808
H	THR733
I	THR733
J	THR733
K	THR733
L	THR733
D	TYR1798
D	SER1808
E	TYR1798

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198

Chain	Residue	Details
G	PHE1127
H	PHE1127
I	PHE1127
J	PHE1127
K	PHE1127
L	PHE1127

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047

Chain	Residue	Details
G	ASP1370
L	ASP1370
B	SER180
H	ASP1370
D	SER180
I	ASP1370
F	SER180
J	ASP1370
K	ASP1370

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	SER523
B	SER523
C	SER523
D	SER523
E	SER523
F	SER523

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950

Chain	Residue	Details
A	SER958
E	SER1440
F	SER958
F	SER1440
A	SER1440
B	SER958
B	SER1440
C	SER958
C	SER1440
D	SER958
D	SER1440
E	SER958

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047

Chain	Residue	Details
A	LYS37
F	LYS37
B	LYS37
C	LYS37
D	LYS37
E	LYS37

---