6QID

Crystal structure of DEAH-box ATPase Prp43-S387A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000390	biological_process	spliceosomal complex disassembly
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0003724	molecular_function	RNA helicase activity
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005681	cellular_component	spliceosomal complex
A	0006397	biological_process	mRNA processing
A	0008380	biological_process	RNA splicing
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0071014	cellular_component	post-mRNA release spliceosomal complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue MPD A 1301

Chain	Residue
A	ARG152
A	GLU222
A	ASN382
A	GLU385
A	THR458
A	ARG464
A	SO41321
A	HOH1468

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site_id	AC2
Number of Residues	2
Details	binding site for residue MPD A 1302

Chain	Residue
A	ARG625
A	LYS595

---

site_id	AC3
Number of Residues	3
Details	binding site for residue MPD A 1303

Chain	Residue
A	ARG368
A	GLY370
A	HOH1560

---

site_id	AC4
Number of Residues	3
Details	binding site for residue MPD A 1304

Chain	Residue
A	TYR135
A	LEU138
A	PRO139

---

site_id	AC5
Number of Residues	2
Details	binding site for residue MPD A 1305

Chain	Residue
A	PRO399
A	GLU453

---

site_id	AC6
Number of Residues	3
Details	binding site for residue PEG A 1306

Chain	Residue
A	PRO517
A	HOH1407
A	HOH1495

---

site_id	AC7
Number of Residues	4
Details	binding site for residue MPD A 1307

Chain	Residue
A	ARG81
A	ARG85
A	ASP168
A	VAL169

---

site_id	AC8
Number of Residues	3
Details	binding site for residue MPD A 1308

Chain	Residue
A	TRP77
A	GLY79
A	ARG287

---

site_id	AC9
Number of Residues	2
Details	binding site for residue MPD A 1309

Chain	Residue
A	PRO460
A	ASP489

---

site_id	AD1
Number of Residues	3
Details	binding site for residue MPD A 1310

Chain	Residue
A	VAL344
A	TYR345
A	ARG358

---

site_id	AD2
Number of Residues	4
Details	binding site for residue MPD A 1311

Chain	Residue
A	THR296
A	GLN299
A	GLU304
A	PHE442

---

site_id	AD3
Number of Residues	2
Details	binding site for residue MPD A 1312

Chain	Residue
A	GLU502
A	GLN664

---

site_id	AD4
Number of Residues	4
Details	binding site for residue PEG A 1313

Chain	Residue
A	ALA251
A	ALA424
A	GLN427
A	GLU456

---

site_id	AD5
Number of Residues	2
Details	binding site for residue CL A 1314

Chain	Residue
A	GLY349
A	THR381

---

site_id	AD6
Number of Residues	3
Details	binding site for residue CL A 1315

Chain	Residue
A	ARG152
A	ARG153
A	HOH1932

---

site_id	AD7
Number of Residues	4
Details	binding site for residue CL A 1316

Chain	Residue
A	ARG153
A	ARG180
A	THR195
A	ARG201

---

site_id	AD8
Number of Residues	8
Details	binding site for residue MG A 1319

Chain	Residue
A	THR126
A	ASP218
A	GLU219
A	ADP1322
A	BEF1323
A	HOH1484
A	HOH1524
A	HOH1603

---

site_id	AD9
Number of Residues	2
Details	binding site for residue SO4 A 1320

Chain	Residue
A	PRO517
A	LEU521

---

site_id	AE1
Number of Residues	5
Details	binding site for residue SO4 A 1321

Chain	Residue
A	GLN404
A	LYS405
A	ARG464
A	MPD1301
A	HOH1475

---

site_id	AE2
Number of Residues	18
Details	binding site for residue ADP A 1322

Chain	Residue
A	GLY122
A	SER123
A	GLY124
A	LYS125
A	THR126
A	THR127
A	ARG162
A	THR389
A	ARG435
A	MG1319
A	BEF1323
A	HOH1430
A	HOH1471
A	HOH1484
A	HOH1521
A	HOH1582
A	HOH1669
A	HOH1777

---

site_id	AE3
Number of Residues	13
Details	binding site for residue BEF A 1323

Chain	Residue
A	THR121
A	LYS125
A	GLU219
A	ALA387
A	ARG432
A	ARG435
A	MG1319
A	ADP1322
A	HOH1460
A	HOH1484
A	HOH1524
A	HOH1603
A	HOH1622

---

Functional Information from PROSITE/UniProt

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. ScIILDEAHE

Chain	Residue	Details
A	SER213-GLU222

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