Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6QFA

CryoEM structure of a beta3K279T GABA(A)R homomer in complex with histamine and megabody Mb25

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0004890	molecular_function	GABA-A receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0004890	molecular_function	GABA-A receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0004890	molecular_function	GABA-A receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0004890	molecular_function	GABA-A receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0004890	molecular_function	GABA-A receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue HSM B 502

Chain	Residue
A	ASP43
A	TYR62
B	TYR97
B	GLU155
B	SER156
B	TYR157
B	PHE200
B	TYR205

site_id	AC2
Number of Residues	8
Details	binding site for residue HSM C 502

Chain	Residue
B	TYR62
C	TYR97
C	GLU155
C	SER156
C	TYR157
C	PHE200
C	TYR205
B	ASP43

site_id	AC3
Number of Residues	8
Details	binding site for residue HSM D 502

Chain	Residue
C	ASP43
C	TYR62
D	TYR97
D	GLU155
D	SER156
D	TYR157
D	PHE200
D	TYR205

site_id	AC4
Number of Residues	8
Details	binding site for residue HSM E 502

Chain	Residue
D	ASP43
D	TYR62
E	TYR97
E	GLU155
E	SER156
E	TYR157
E	PHE200
E	TYR205

site_id	AC5
Number of Residues	8
Details	binding site for residue HSM A 502

Chain	Residue
A	TYR97
A	GLU155
A	SER156
A	TYR157
A	PHE200
A	TYR205
E	ASP43
E	TYR62

site_id	AC6
Number of Residues	3
Details	binding site for Mono-Saccharide NAG A 501 bound to ASN A 80

Chain	Residue
A	PRO78
A	ASN80
A	HIS119

site_id	AC7
Number of Residues	10
Details	binding site for Poly-Saccharide residues NAG A 502 through MAN A 506 bound to ASN A 149

Chain	Residue
A	ASN149
A	ARG192
A	SER195
A	ARG196
A	ASN197
A	SER211
A	ARG213
O	ASN417
O	TYR418
O	ASP500

site_id	AC8
Number of Residues	3
Details	binding site for Mono-Saccharide NAG B 501 bound to ASN B 80

Chain	Residue
B	PRO78
B	ASN80
B	HIS119

site_id	AC9
Number of Residues	10
Details	binding site for Poly-Saccharide residues NAG B 502 through MAN B 506 bound to ASN B 149

Chain	Residue
B	ASN149
B	ARG192
B	SER195
B	ARG196
B	ASN197
B	SER211
B	ARG213
K	ASN417
K	TYR418
K	ASP500

site_id	AD1
Number of Residues	3
Details	binding site for Mono-Saccharide NAG C 501 bound to ASN C 80

Chain	Residue
C	PRO78
C	ASN80
C	HIS119

site_id	AD2
Number of Residues	9
Details	binding site for Poly-Saccharide residues NAG C 502 through MAN C 506 bound to ASN C 149

Chain	Residue
C	ASN149
C	ARG192
C	SER195
C	ARG196
C	ASN197
C	SER211
C	ARG213
L	TYR418
L	ASP500

site_id	AD3
Number of Residues	3
Details	binding site for Mono-Saccharide NAG D 501 bound to ASN D 80

Chain	Residue
D	PRO78
D	ASN80
D	HIS119

site_id	AD4
Number of Residues	9
Details	binding site for Poly-Saccharide residues NAG D 502 through MAN D 506 bound to ASN D 149

Chain	Residue
D	ASN149
D	ARG192
D	SER195
D	ARG196
D	ASN197
D	SER211
D	ARG213
M	TYR418
M	ASP500

site_id	AD5
Number of Residues	3
Details	binding site for Mono-Saccharide NAG E 501 bound to ASN E 80

Chain	Residue
E	PRO78
E	ASN80
E	HIS119

site_id	AD6
Number of Residues	10
Details	binding site for Poly-Saccharide residues NAG E 502 through MAN E 506 bound to ASN E 149

Chain	Residue
E	ARG213
N	ASN417
N	TYR418
N	ASP500
E	ASN149
E	ARG192
E	SER195
E	ARG196
E	ASN197
E	SER211

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CmMdLrrYPlDeqnC

Chain	Residue	Details
B	CYS136-CYS150

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	425
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	15
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	55
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	15
Details	Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4COF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	5
Details	Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	5
Details	Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"30140029","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A96","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"24909990","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30140029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30602789","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35355020","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A96","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I53","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7QN7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)