Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6QEM

E. coli DnaBC complex bound to ssDNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003677	molecular_function	DNA binding
A	0003678	molecular_function	DNA helicase activity
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006269	biological_process	DNA replication, synthesis of primer
A	0006270	biological_process	DNA replication initiation
A	0010212	biological_process	response to ionizing radiation
A	0016787	molecular_function	hydrolase activity
A	0016853	molecular_function	isomerase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0030894	cellular_component	replisome
A	0031297	biological_process	replication fork processing
A	0033202	cellular_component	DNA helicase complex
A	0042802	molecular_function	identical protein binding
A	0043139	molecular_function	5'-3' DNA helicase activity
A	1990077	cellular_component	primosome complex
A	1990100	cellular_component	DnaB-DnaC complex
A	1990156	cellular_component	DnaB-DnaG complex
A	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
A	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
A	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
B	0000166	molecular_function	nucleotide binding
B	0003677	molecular_function	DNA binding
B	0003678	molecular_function	DNA helicase activity
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0006260	biological_process	DNA replication
B	0006269	biological_process	DNA replication, synthesis of primer
B	0006270	biological_process	DNA replication initiation
B	0010212	biological_process	response to ionizing radiation
B	0016787	molecular_function	hydrolase activity
B	0016853	molecular_function	isomerase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0030894	cellular_component	replisome
B	0031297	biological_process	replication fork processing
B	0033202	cellular_component	DNA helicase complex
B	0042802	molecular_function	identical protein binding
B	0043139	molecular_function	5'-3' DNA helicase activity
B	1990077	cellular_component	primosome complex
B	1990100	cellular_component	DnaB-DnaC complex
B	1990156	cellular_component	DnaB-DnaG complex
B	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
B	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
B	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
C	0000166	molecular_function	nucleotide binding
C	0003677	molecular_function	DNA binding
C	0003678	molecular_function	DNA helicase activity
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005829	cellular_component	cytosol
C	0006260	biological_process	DNA replication
C	0006269	biological_process	DNA replication, synthesis of primer
C	0006270	biological_process	DNA replication initiation
C	0010212	biological_process	response to ionizing radiation
C	0016787	molecular_function	hydrolase activity
C	0016853	molecular_function	isomerase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0030894	cellular_component	replisome
C	0031297	biological_process	replication fork processing
C	0033202	cellular_component	DNA helicase complex
C	0042802	molecular_function	identical protein binding
C	0043139	molecular_function	5'-3' DNA helicase activity
C	1990077	cellular_component	primosome complex
C	1990100	cellular_component	DnaB-DnaC complex
C	1990156	cellular_component	DnaB-DnaG complex
C	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
C	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
C	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
D	0000166	molecular_function	nucleotide binding
D	0003677	molecular_function	DNA binding
D	0003678	molecular_function	DNA helicase activity
D	0004386	molecular_function	helicase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005829	cellular_component	cytosol
D	0006260	biological_process	DNA replication
D	0006269	biological_process	DNA replication, synthesis of primer
D	0006270	biological_process	DNA replication initiation
D	0010212	biological_process	response to ionizing radiation
D	0016787	molecular_function	hydrolase activity
D	0016853	molecular_function	isomerase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0030894	cellular_component	replisome
D	0031297	biological_process	replication fork processing
D	0033202	cellular_component	DNA helicase complex
D	0042802	molecular_function	identical protein binding
D	0043139	molecular_function	5'-3' DNA helicase activity
D	1990077	cellular_component	primosome complex
D	1990100	cellular_component	DnaB-DnaC complex
D	1990156	cellular_component	DnaB-DnaG complex
D	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
D	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
D	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
E	0000166	molecular_function	nucleotide binding
E	0003677	molecular_function	DNA binding
E	0003678	molecular_function	DNA helicase activity
E	0004386	molecular_function	helicase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005829	cellular_component	cytosol
E	0006260	biological_process	DNA replication
E	0006269	biological_process	DNA replication, synthesis of primer
E	0006270	biological_process	DNA replication initiation
E	0010212	biological_process	response to ionizing radiation
E	0016787	molecular_function	hydrolase activity
E	0016853	molecular_function	isomerase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0030894	cellular_component	replisome
E	0031297	biological_process	replication fork processing
E	0033202	cellular_component	DNA helicase complex
E	0042802	molecular_function	identical protein binding
E	0043139	molecular_function	5'-3' DNA helicase activity
E	1990077	cellular_component	primosome complex
E	1990100	cellular_component	DnaB-DnaC complex
E	1990156	cellular_component	DnaB-DnaG complex
E	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
E	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
E	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
F	0000166	molecular_function	nucleotide binding
F	0003677	molecular_function	DNA binding
F	0003678	molecular_function	DNA helicase activity
F	0004386	molecular_function	helicase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005829	cellular_component	cytosol
F	0006260	biological_process	DNA replication
F	0006269	biological_process	DNA replication, synthesis of primer
F	0006270	biological_process	DNA replication initiation
F	0010212	biological_process	response to ionizing radiation
F	0016787	molecular_function	hydrolase activity
F	0016853	molecular_function	isomerase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0030894	cellular_component	replisome
F	0031297	biological_process	replication fork processing
F	0033202	cellular_component	DNA helicase complex
F	0042802	molecular_function	identical protein binding
F	0043139	molecular_function	5'-3' DNA helicase activity
F	1990077	cellular_component	primosome complex
F	1990100	cellular_component	DnaB-DnaC complex
F	1990156	cellular_component	DnaB-DnaG complex
F	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
F	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
F	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
G	0000166	molecular_function	nucleotide binding
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0006260	biological_process	DNA replication
G	0006269	biological_process	DNA replication, synthesis of primer
G	0006270	biological_process	DNA replication initiation
G	0006271	biological_process	DNA strand elongation involved in DNA replication
G	0016787	molecular_function	hydrolase activity
G	0031297	biological_process	replication fork processing
G	1990077	cellular_component	primosome complex
G	1990100	cellular_component	DnaB-DnaC complex
G	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
G	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
G	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
H	0000166	molecular_function	nucleotide binding
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0006260	biological_process	DNA replication
H	0006269	biological_process	DNA replication, synthesis of primer
H	0006270	biological_process	DNA replication initiation
H	0006271	biological_process	DNA strand elongation involved in DNA replication
H	0016787	molecular_function	hydrolase activity
H	0031297	biological_process	replication fork processing
H	1990077	cellular_component	primosome complex
H	1990100	cellular_component	DnaB-DnaC complex
H	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
H	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
H	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
I	0000166	molecular_function	nucleotide binding
I	0003677	molecular_function	DNA binding
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0006260	biological_process	DNA replication
I	0006269	biological_process	DNA replication, synthesis of primer
I	0006270	biological_process	DNA replication initiation
I	0006271	biological_process	DNA strand elongation involved in DNA replication
I	0016787	molecular_function	hydrolase activity
I	0031297	biological_process	replication fork processing
I	1990077	cellular_component	primosome complex
I	1990100	cellular_component	DnaB-DnaC complex
I	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
I	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
I	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
J	0000166	molecular_function	nucleotide binding
J	0003677	molecular_function	DNA binding
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0006260	biological_process	DNA replication
J	0006269	biological_process	DNA replication, synthesis of primer
J	0006270	biological_process	DNA replication initiation
J	0006271	biological_process	DNA strand elongation involved in DNA replication
J	0016787	molecular_function	hydrolase activity
J	0031297	biological_process	replication fork processing
J	1990077	cellular_component	primosome complex
J	1990100	cellular_component	DnaB-DnaC complex
J	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
J	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
J	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
K	0000166	molecular_function	nucleotide binding
K	0003677	molecular_function	DNA binding
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0006260	biological_process	DNA replication
K	0006269	biological_process	DNA replication, synthesis of primer
K	0006270	biological_process	DNA replication initiation
K	0006271	biological_process	DNA strand elongation involved in DNA replication
K	0016787	molecular_function	hydrolase activity
K	0031297	biological_process	replication fork processing
K	1990077	cellular_component	primosome complex
K	1990100	cellular_component	DnaB-DnaC complex
K	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
K	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
K	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
L	0000166	molecular_function	nucleotide binding
L	0003677	molecular_function	DNA binding
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0006260	biological_process	DNA replication
L	0006269	biological_process	DNA replication, synthesis of primer
L	0006270	biological_process	DNA replication initiation
L	0006271	biological_process	DNA strand elongation involved in DNA replication
L	0016787	molecular_function	hydrolase activity
L	0031297	biological_process	replication fork processing
L	1990077	cellular_component	primosome complex
L	1990100	cellular_component	DnaB-DnaC complex
L	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
L	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
L	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue 08T A 1001

Chain	Residue
A	PRO233
A	ARG420
A	GLY455
A	MG1002
F	LYS440
F	GLN441
F	ARG442
F	GLY444
F	PRO445
A	SER234
A	GLY236
A	LYS237
A	THR238
A	THR239
A	GLU262
A	ARG271
A	GLN384

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 1002

Chain	Residue
A	THR238
A	GLU262
A	ASP343
A	08T1001

site_id	AC3
Number of Residues	15
Details	binding site for residue 08T B 1001

Chain	Residue
A	GLN441
A	ARG442
A	GLY444
A	PRO445
B	PRO233
B	SER234
B	GLY236
B	LYS237
B	THR238
B	THR239
B	GLU262
B	ARG271
B	GLN384
B	GLY455
B	MG1002

site_id	AC4
Number of Residues	4
Details	binding site for residue MG B 1002

Chain	Residue
B	THR238
B	GLU262
B	ASP343
B	08T1001

site_id	AC5
Number of Residues	15
Details	binding site for residue 08T C 1001

Chain	Residue
B	LYS440
B	GLN441
B	ARG442
B	GLY444
B	PRO445
C	PRO233
C	SER234
C	GLY236
C	LYS237
C	THR238
C	THR239
C	GLU262
C	ARG271
C	GLN384
C	MG1002

site_id	AC6
Number of Residues	3
Details	binding site for residue MG C 1002

Chain	Residue
C	THR238
C	GLU262
C	08T1001

site_id	AC7
Number of Residues	17
Details	binding site for residue 08T D 1001

Chain	Residue
C	GLN441
C	ARG442
C	GLY444
C	PRO445
D	PRO233
D	SER234
D	GLY236
D	LYS237
D	THR238
D	THR239
D	GLU262
D	ARG271
D	GLN281
D	GLN384
D	ARG420
D	GLY455
D	MG1002

site_id	AC8
Number of Residues	4
Details	binding site for residue MG D 1002

Chain	Residue
D	THR238
D	GLU262
D	ASP343
D	08T1001

site_id	AC9
Number of Residues	16
Details	binding site for residue 08T E 1001

Chain	Residue
D	GLN441
D	ARG442
D	GLY444
D	PRO445
E	PRO233
E	SER234
E	GLY236
E	LYS237
E	THR238
E	THR239
E	GLU262
E	ARG271
E	GLN384
E	ARG420
E	GLY455
E	MG1002

site_id	AD1
Number of Residues	3
Details	binding site for residue MG E 1002

Chain	Residue
E	THR238
E	GLU262
E	08T1001

site_id	AD2
Number of Residues	13
Details	binding site for residue ADP G 301

Chain	Residue
G	ASN73
G	TYR74
G	ARG75
G	PRO108
G	GLY109
G	THR110
G	GLY111
G	LYS112
G	ASN113
G	TYR236
G	ARG237
L	ARG216
G	HIS66

site_id	AD3
Number of Residues	11
Details	binding site for residue ADP H 301

Chain	Residue
H	HIS66
H	ASN73
H	TYR74
H	ARG75
H	PRO108
H	GLY109
H	THR110
H	GLY111
H	LYS112
H	ASN113
H	TYR236

site_id	AD4
Number of Residues	13
Details	binding site for residue ADP I 301

Chain	Residue
H	ARG216
H	ARG220
I	ASN73
I	TYR74
I	ARG75
I	PRO108
I	GLY109
I	THR110
I	GLY111
I	LYS112
I	ASN113
I	HIS114
I	TYR236

site_id	AD5
Number of Residues	12
Details	binding site for residue ADP J 301

Chain	Residue
J	HIS66
J	TYR74
J	ARG75
J	PRO108
J	GLY109
J	THR110
J	GLY111
J	LYS112
J	ASN113
J	HIS114
J	TYR236
J	ARG237

site_id	AD6
Number of Residues	13
Details	binding site for residue ADP K 301

Chain	Residue
J	ARG216
K	HIS66
K	TYR74
K	ARG75
K	PRO108
K	GLY109
K	THR110
K	GLY111
K	LYS112
K	ASN113
K	HIS114
K	TYR236
K	ARG237

site_id	AD7
Number of Residues	13
Details	binding site for residue ADP L 301

Chain	Residue
L	HIS66
L	ASN73
L	TYR74
L	ARG75
L	GLN81
L	PRO108
L	GLY109
L	THR110
L	GLY111
L	LYS112
L	ASN113
L	HIS114
L	TYR236

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1602
Details	Domain: {"description":"SF4 helicase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00596","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30582519","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6BBM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Site: {"description":"Probably involved in interaction with DnaB protein","evidences":[{"source":"PubMed","id":"3301836","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)