Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6QEL

E. coli DnaBC apo complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003678	molecular_function	DNA helicase activity
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006268	biological_process	DNA unwinding involved in DNA replication
A	0006269	biological_process	DNA replication, synthesis of primer
A	0006270	biological_process	DNA replication initiation
A	0010212	biological_process	response to ionizing radiation
A	0016787	molecular_function	hydrolase activity
A	0016853	molecular_function	isomerase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0030894	cellular_component	replisome
A	0031297	biological_process	replication fork processing
A	0032508	biological_process	DNA duplex unwinding
A	0033202	cellular_component	DNA helicase complex
A	0042802	molecular_function	identical protein binding
A	0043139	molecular_function	5'-3' DNA helicase activity
A	1990077	cellular_component	primosome complex
A	1990100	cellular_component	DnaB-DnaC complex
A	1990156	cellular_component	DnaB-DnaG complex
A	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
A	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
A	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
B	0003677	molecular_function	DNA binding
B	0003678	molecular_function	DNA helicase activity
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0006260	biological_process	DNA replication
B	0006268	biological_process	DNA unwinding involved in DNA replication
B	0006269	biological_process	DNA replication, synthesis of primer
B	0006270	biological_process	DNA replication initiation
B	0010212	biological_process	response to ionizing radiation
B	0016787	molecular_function	hydrolase activity
B	0016853	molecular_function	isomerase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0030894	cellular_component	replisome
B	0031297	biological_process	replication fork processing
B	0032508	biological_process	DNA duplex unwinding
B	0033202	cellular_component	DNA helicase complex
B	0042802	molecular_function	identical protein binding
B	0043139	molecular_function	5'-3' DNA helicase activity
B	1990077	cellular_component	primosome complex
B	1990100	cellular_component	DnaB-DnaC complex
B	1990156	cellular_component	DnaB-DnaG complex
B	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
B	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
B	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
C	0003677	molecular_function	DNA binding
C	0003678	molecular_function	DNA helicase activity
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005829	cellular_component	cytosol
C	0006260	biological_process	DNA replication
C	0006268	biological_process	DNA unwinding involved in DNA replication
C	0006269	biological_process	DNA replication, synthesis of primer
C	0006270	biological_process	DNA replication initiation
C	0010212	biological_process	response to ionizing radiation
C	0016787	molecular_function	hydrolase activity
C	0016853	molecular_function	isomerase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0030894	cellular_component	replisome
C	0031297	biological_process	replication fork processing
C	0032508	biological_process	DNA duplex unwinding
C	0033202	cellular_component	DNA helicase complex
C	0042802	molecular_function	identical protein binding
C	0043139	molecular_function	5'-3' DNA helicase activity
C	1990077	cellular_component	primosome complex
C	1990100	cellular_component	DnaB-DnaC complex
C	1990156	cellular_component	DnaB-DnaG complex
C	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
C	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
C	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
D	0003677	molecular_function	DNA binding
D	0003678	molecular_function	DNA helicase activity
D	0004386	molecular_function	helicase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005829	cellular_component	cytosol
D	0006260	biological_process	DNA replication
D	0006268	biological_process	DNA unwinding involved in DNA replication
D	0006269	biological_process	DNA replication, synthesis of primer
D	0006270	biological_process	DNA replication initiation
D	0010212	biological_process	response to ionizing radiation
D	0016787	molecular_function	hydrolase activity
D	0016853	molecular_function	isomerase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0030894	cellular_component	replisome
D	0031297	biological_process	replication fork processing
D	0032508	biological_process	DNA duplex unwinding
D	0033202	cellular_component	DNA helicase complex
D	0042802	molecular_function	identical protein binding
D	0043139	molecular_function	5'-3' DNA helicase activity
D	1990077	cellular_component	primosome complex
D	1990100	cellular_component	DnaB-DnaC complex
D	1990156	cellular_component	DnaB-DnaG complex
D	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
D	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
D	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
E	0003677	molecular_function	DNA binding
E	0003678	molecular_function	DNA helicase activity
E	0004386	molecular_function	helicase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005829	cellular_component	cytosol
E	0006260	biological_process	DNA replication
E	0006268	biological_process	DNA unwinding involved in DNA replication
E	0006269	biological_process	DNA replication, synthesis of primer
E	0006270	biological_process	DNA replication initiation
E	0010212	biological_process	response to ionizing radiation
E	0016787	molecular_function	hydrolase activity
E	0016853	molecular_function	isomerase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0030894	cellular_component	replisome
E	0031297	biological_process	replication fork processing
E	0032508	biological_process	DNA duplex unwinding
E	0033202	cellular_component	DNA helicase complex
E	0042802	molecular_function	identical protein binding
E	0043139	molecular_function	5'-3' DNA helicase activity
E	1990077	cellular_component	primosome complex
E	1990100	cellular_component	DnaB-DnaC complex
E	1990156	cellular_component	DnaB-DnaG complex
E	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
E	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
E	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
F	0003677	molecular_function	DNA binding
F	0003678	molecular_function	DNA helicase activity
F	0004386	molecular_function	helicase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005829	cellular_component	cytosol
F	0006260	biological_process	DNA replication
F	0006268	biological_process	DNA unwinding involved in DNA replication
F	0006269	biological_process	DNA replication, synthesis of primer
F	0006270	biological_process	DNA replication initiation
F	0010212	biological_process	response to ionizing radiation
F	0016787	molecular_function	hydrolase activity
F	0016853	molecular_function	isomerase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0030894	cellular_component	replisome
F	0031297	biological_process	replication fork processing
F	0032508	biological_process	DNA duplex unwinding
F	0033202	cellular_component	DNA helicase complex
F	0042802	molecular_function	identical protein binding
F	0043139	molecular_function	5'-3' DNA helicase activity
F	1990077	cellular_component	primosome complex
F	1990100	cellular_component	DnaB-DnaC complex
F	1990156	cellular_component	DnaB-DnaG complex
F	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
F	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
F	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0006260	biological_process	DNA replication
G	0006268	biological_process	DNA unwinding involved in DNA replication
G	0006269	biological_process	DNA replication, synthesis of primer
G	0006270	biological_process	DNA replication initiation
G	0006271	biological_process	DNA strand elongation involved in DNA replication
G	0016787	molecular_function	hydrolase activity
G	0016887	molecular_function	ATP hydrolysis activity
G	0031297	biological_process	replication fork processing
G	1990077	cellular_component	primosome complex
G	1990100	cellular_component	DnaB-DnaC complex
G	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
G	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
G	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0006260	biological_process	DNA replication
H	0006268	biological_process	DNA unwinding involved in DNA replication
H	0006269	biological_process	DNA replication, synthesis of primer
H	0006270	biological_process	DNA replication initiation
H	0006271	biological_process	DNA strand elongation involved in DNA replication
H	0016787	molecular_function	hydrolase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0031297	biological_process	replication fork processing
H	1990077	cellular_component	primosome complex
H	1990100	cellular_component	DnaB-DnaC complex
H	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
H	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
H	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
I	0003677	molecular_function	DNA binding
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0006260	biological_process	DNA replication
I	0006268	biological_process	DNA unwinding involved in DNA replication
I	0006269	biological_process	DNA replication, synthesis of primer
I	0006270	biological_process	DNA replication initiation
I	0006271	biological_process	DNA strand elongation involved in DNA replication
I	0016787	molecular_function	hydrolase activity
I	0016887	molecular_function	ATP hydrolysis activity
I	0031297	biological_process	replication fork processing
I	1990077	cellular_component	primosome complex
I	1990100	cellular_component	DnaB-DnaC complex
I	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
I	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
I	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
J	0003677	molecular_function	DNA binding
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0006260	biological_process	DNA replication
J	0006268	biological_process	DNA unwinding involved in DNA replication
J	0006269	biological_process	DNA replication, synthesis of primer
J	0006270	biological_process	DNA replication initiation
J	0006271	biological_process	DNA strand elongation involved in DNA replication
J	0016787	molecular_function	hydrolase activity
J	0016887	molecular_function	ATP hydrolysis activity
J	0031297	biological_process	replication fork processing
J	1990077	cellular_component	primosome complex
J	1990100	cellular_component	DnaB-DnaC complex
J	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
J	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
J	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
K	0003677	molecular_function	DNA binding
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0006260	biological_process	DNA replication
K	0006268	biological_process	DNA unwinding involved in DNA replication
K	0006269	biological_process	DNA replication, synthesis of primer
K	0006270	biological_process	DNA replication initiation
K	0006271	biological_process	DNA strand elongation involved in DNA replication
K	0016787	molecular_function	hydrolase activity
K	0016887	molecular_function	ATP hydrolysis activity
K	0031297	biological_process	replication fork processing
K	1990077	cellular_component	primosome complex
K	1990100	cellular_component	DnaB-DnaC complex
K	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
K	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
K	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex
L	0003677	molecular_function	DNA binding
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0006260	biological_process	DNA replication
L	0006268	biological_process	DNA unwinding involved in DNA replication
L	0006269	biological_process	DNA replication, synthesis of primer
L	0006270	biological_process	DNA replication initiation
L	0006271	biological_process	DNA strand elongation involved in DNA replication
L	0016787	molecular_function	hydrolase activity
L	0016887	molecular_function	ATP hydrolysis activity
L	0031297	biological_process	replication fork processing
L	1990077	cellular_component	primosome complex
L	1990100	cellular_component	DnaB-DnaC complex
L	1990158	cellular_component	DnaB-DnaC-DnaT-PriA-PriB complex
L	1990159	cellular_component	DnaB-DnaC-DnaT-PriA-PriC complex
L	1990160	cellular_component	DnaB-DnaC-Rep-PriC complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue ADP A 1001

Chain	Residue
A	PRO233
A	SER234
A	GLY236
A	LYS237
A	THR238
A	THR239
A	ARG420
A	GLY455
A	MG1002

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 1002

Chain	Residue
A	THR238
A	GLU262
A	ASP343
A	ADP1001

site_id	AC3
Number of Residues	15
Details	binding site for residue ADP B 1001

Chain	Residue
A	GLN441
A	ARG442
A	GLY444
A	PRO445
B	PRO233
B	SER234
B	GLY236
B	LYS237
B	THR238
B	THR239
B	GLU262
B	ARG271
B	PHE453
B	GLY455
B	MG1002

site_id	AC4
Number of Residues	4
Details	binding site for residue MG B 1002

Chain	Residue
A	ARG442
B	THR238
B	GLU262
B	ADP1001

site_id	AC5
Number of Residues	14
Details	binding site for residue ADP C 1001

Chain	Residue
B	ARG442
B	ASN443
B	GLY444
C	PRO233
C	SER234
C	GLY236
C	LYS237
C	THR238
C	GLU262
C	ARG271
C	PHE453
C	GLY455
C	GLN456
C	MG1002

site_id	AC6
Number of Residues	4
Details	binding site for residue MG C 1002

Chain	Residue
B	ARG442
C	THR238
C	GLU262
C	ADP1001

site_id	AC7
Number of Residues	15
Details	binding site for residue ADP D 1001

Chain	Residue
C	ARG442
C	ASN443
C	GLY444
D	PRO233
D	SER234
D	LYS237
D	THR238
D	THR239
D	GLU262
D	ARG271
D	GLN281
D	PHE453
D	GLY455
D	GLN456
D	MG1002

site_id	AC8
Number of Residues	5
Details	binding site for residue MG D 1002

Chain	Residue
C	ARG442
D	THR238
D	GLU262
D	ASP343
D	ADP1001

site_id	AC9
Number of Residues	15
Details	binding site for residue ADP E 1001

Chain	Residue
D	LYS440
D	GLN441
D	ARG442
D	ASN443
D	GLY444
E	PRO233
E	SER234
E	GLY236
E	LYS237
E	THR238
E	THR239
E	GLU262
E	PHE453
E	GLY455
E	MG1002

site_id	AD1
Number of Residues	4
Details	binding site for residue MG E 1002

Chain	Residue
E	THR238
E	GLU262
E	ASP343
E	ADP1001

site_id	AD2
Number of Residues	14
Details	binding site for residue ADP F 1001

Chain	Residue
F	PHE453
F	GLY455
F	GLN456
F	MG1002
E	ARG442
E	ASN443
E	PRO445
F	PRO233
F	SER234
F	GLY236
F	LYS237
F	THR238
F	THR239
F	GLU262

site_id	AD3
Number of Residues	4
Details	binding site for residue MG F 1002

Chain	Residue
E	ARG442
F	THR238
F	GLU262
F	ADP1001

site_id	AD4
Number of Residues	11
Details	binding site for residue ADP G 301

Chain	Residue
G	HIS66
G	TYR74
G	ARG75
G	PRO108
G	GLY109
G	THR110
G	GLY111
G	LYS112
G	ASN113
G	HIS114
G	MG302

site_id	AD5
Number of Residues	4
Details	binding site for residue MG G 302

Chain	Residue
G	LYS112
G	ASN113
G	ASP169
G	ADP301

site_id	AD6
Number of Residues	14
Details	binding site for residue 08T H 301

Chain	Residue
G	ARG220
H	HIS66
H	ASN73
H	TYR74
H	ARG75
H	PRO108
H	GLY109
H	THR110
H	GLY111
H	LYS112
H	ASN113
H	HIS114
H	ARG237
H	MG302

site_id	AD7
Number of Residues	4
Details	binding site for residue MG H 302

Chain	Residue
G	ARG220
H	ASN113
H	ASP169
H	08T301

site_id	AD8
Number of Residues	16
Details	binding site for residue 08T I 301

Chain	Residue
H	ARG220
I	LEU65
I	HIS66
I	ASN73
I	TYR74
I	ARG75
I	GLY109
I	THR110
I	GLY111
I	LYS112
I	ASN113
I	HIS114
I	ASN203
I	TYR236
I	ARG237
I	MG302

site_id	AD9
Number of Residues	3
Details	binding site for residue MG I 302

Chain	Residue
I	ASN113
I	ASP169
I	08T301

site_id	AE1
Number of Residues	13
Details	binding site for residue 08T J 301

Chain	Residue
I	ARG220
J	LEU65
J	HIS66
J	ASN73
J	TYR74
J	GLY109
J	GLY111
J	LYS112
J	ASN113
J	HIS114
J	ASN203
J	ARG237
J	MG302

site_id	AE2
Number of Residues	4
Details	binding site for residue MG J 302

Chain	Residue
J	LYS112
J	ASN113
J	ASP169
J	08T301

site_id	AE3
Number of Residues	13
Details	binding site for residue 08T K 301

Chain	Residue
J	ARG220
K	LEU65
K	HIS66
K	ASN73
K	TYR74
K	PRO108
K	THR110
K	GLY111
K	LYS112
K	ASN113
K	HIS114
K	ARG237
K	MG302

site_id	AE4
Number of Residues	4
Details	binding site for residue MG K 302

Chain	Residue
J	ARG220
K	ASN113
K	ASP169
K	08T301

site_id	AE5
Number of Residues	14
Details	binding site for residue 08T L 301

Chain	Residue
K	ARG220
L	LEU65
L	HIS66
L	ASN73
L	TYR74
L	THR110
L	GLY111
L	LYS112
L	ASN113
L	HIS114
L	ASN203
L	TYR236
L	ARG237
L	MG302

site_id	AE6
Number of Residues	4
Details	binding site for residue MG L 302

Chain	Residue
L	LYS112
L	ASN113
L	ASP169
L	08T301

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	SITE: Probably involved in the interaction with the DnaB protein

Chain	Residue	Details
G	CYS69
H	CYS69
I	CYS69
J	CYS69
K	CYS69
L	CYS69

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)