6QDJ

Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003774	molecular_function	cytoskeletal motor activity
A	0005524	molecular_function	ATP binding
A	0016459	cellular_component	myosin complex
A	0051015	molecular_function	actin filament binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue ADP A 801

Chain	Residue
A	ASN122
A	LYS180
A	THR181
A	GLU182
A	ASN236
A	ASN238
A	HOH927
A	HOH939
A	HOH960
A	HOH979
A	HOH1072
A	PRO123
A	HOH1108
A	TYR124
A	LYS125
A	TYR130
A	GLU175
A	GLY177
A	ALA178
A	GLY179

---

site_id	AC2
Number of Residues	8
Details	binding site for residue GOL A 802

Chain	Residue
A	ASN359
A	LYS361
A	ASP374
A	GLY375
A	ASP377
A	GLU378
A	HOH1047
A	HOH1048

---

site_id	AC3
Number of Residues	5
Details	binding site for residue GOL A 803

Chain	Residue
A	SER531
A	ASP534
A	GLU535
A	ARG659
A	HOH938

---

site_id	AC4
Number of Residues	7
Details	binding site for residue GOL A 804

Chain	Residue
A	SER114
A	GLY115
A	LEU116
A	MET492
A	GLY708
A	CYS712
A	HOH1012

---

site_id	AC5
Number of Residues	8
Details	binding site for residue GOL A 805

Chain	Residue
A	GLU482
A	ASP515
A	LEU516
A	CYS519
A	ARG580
A	HIS581
A	TYR582
A	HOH1057

---

site_id	AC6
Number of Residues	8
Details	binding site for residue GOL A 806

Chain	Residue
A	THR173
A	GLY174
A	GLU175
A	GLY463
A	PHE464
A	ASN703
A	GOL810
A	PGO814

---

site_id	AC7
Number of Residues	8
Details	binding site for residue GOL A 807

Chain	Residue
A	ARG241
A	GLY243
A	LEU265
A	ILE461
A	ALA462
A	HOH992
A	HOH1081
A	HOH1109

---

site_id	AC8
Number of Residues	3
Details	binding site for residue GOL A 808

Chain	Residue
A	ASN251
A	ASP692
A	ALA694

---

site_id	AC9
Number of Residues	7
Details	binding site for residue GOL A 809

Chain	Residue
A	TYR113
A	GLY115
A	LEU116
A	PHE117
A	LYS143
A	HIS675
A	PHE676

---

site_id	AD1
Number of Residues	6
Details	binding site for residue GOL A 810

Chain	Residue
A	GLU175
A	PHE464
A	GLU465
A	ILE466
A	ASN698
A	GOL806

---

site_id	AD2
Number of Residues	3
Details	binding site for residue GOL A 811

Chain	Residue
A	ASP511
A	LEU514
A	ASP515

---

site_id	AD3
Number of Residues	6
Details	binding site for residue BU1 A 812

Chain	Residue
A	GLN486
A	HIS490
A	ASP511
A	GLY513
A	ASN670
A	HOH926

---

site_id	AD4
Number of Residues	3
Details	binding site for residue PGO A 813

Chain	Residue
A	GLU84
A	ASN88
A	MET146

---

site_id	AD5
Number of Residues	7
Details	binding site for residue PGO A 814

Chain	Residue
A	THR173
A	PHE464
A	ASN481
A	GLN485
A	CYS702
A	GOL806
A	HOH1004

---

site_id	AD6
Number of Residues	7
Details	binding site for residue HEZ A 815

Chain	Residue
A	ARG432
A	ASN435
A	TRP436
A	LYS439
A	LEU443
A	GLU620
A	ILE621

---

site_id	AD7
Number of Residues	10
Details	binding site for residue P15 A 816

Chain	Residue
A	LYS268
A	ILE272
A	ARG273
A	TRP420
A	ALA424
A	LYS427
A	ASN592
A	GLU595
A	LYS596
A	ASP599

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	49
Details	Domain: {"description":"Myosin N-terminal SH3-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU01190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Region: {"description":"Actin-binding"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N6,N6,N6-trimethyllysine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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