Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6QC4

Ovine respiratory supercomplex I+III2 open class 3

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
4L	0005739	cellular_component	mitochondrion
4L	0005743	cellular_component	mitochondrial inner membrane
4L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
4L	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
4L	0030964	cellular_component	NADH dehydrogenase complex
4L	0042773	biological_process	ATP synthesis coupled electron transport
4L	0045271	cellular_component	respiratory chain complex I
4L	1902600	biological_process	proton transmembrane transport
A3	0005743	cellular_component	mitochondrial inner membrane
A3	0045271	cellular_component	respiratory chain complex I
A5	0022904	biological_process	respiratory electron transport chain
A6	0005739	cellular_component	mitochondrion
A6	0005743	cellular_component	mitochondrial inner membrane
A6	0006979	biological_process	response to oxidative stress
A6	0031966	cellular_component	mitochondrial membrane
A6	0032981	biological_process	mitochondrial respiratory chain complex I assembly
A6	0045271	cellular_component	respiratory chain complex I
A7	0005739	cellular_component	mitochondrion
A7	0005743	cellular_component	mitochondrial inner membrane
A7	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A7	0042773	biological_process	ATP synthesis coupled electron transport
A8	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AA	0006633	biological_process	fatty acid biosynthetic process
AB	0006633	biological_process	fatty acid biosynthetic process
AJ	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
AK	0032981	biological_process	mitochondrial respiratory chain complex I assembly
AL	0016020	cellular_component	membrane
AL	0032981	biological_process	mitochondrial respiratory chain complex I assembly
B1	0005739	cellular_component	mitochondrion
B1	0005743	cellular_component	mitochondrial inner membrane
B2	0005743	cellular_component	mitochondrial inner membrane
B2	0045271	cellular_component	respiratory chain complex I
B3	0005739	cellular_component	mitochondrion
B3	0022900	biological_process	electron transport chain
B4	0005739	cellular_component	mitochondrion
B4	0005743	cellular_component	mitochondrial inner membrane
B6	0005739	cellular_component	mitochondrion
B6	0005743	cellular_component	mitochondrial inner membrane
B6	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
B6	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
B7	0005739	cellular_component	mitochondrion
B8	0005739	cellular_component	mitochondrion
B8	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
B9	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
C1	0005739	cellular_component	mitochondrion
C1	0045271	cellular_component	respiratory chain complex I
C2	0005737	cellular_component	cytoplasm
C2	0005739	cellular_component	mitochondrion
C2	0005743	cellular_component	mitochondrial inner membrane
C2	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
C2	0032981	biological_process	mitochondrial respiratory chain complex I assembly
C2	0045271	cellular_component	respiratory chain complex I
D1	0003954	molecular_function	NADH dehydrogenase activity
D1	0005739	cellular_component	mitochondrion
D1	0005743	cellular_component	mitochondrial inner membrane
D1	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D1	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D1	0009060	biological_process	aerobic respiration
D1	0016020	cellular_component	membrane
D1	0031966	cellular_component	mitochondrial membrane
D1	0032981	biological_process	mitochondrial respiratory chain complex I assembly
D1	0045271	cellular_component	respiratory chain complex I
D1	1902600	biological_process	proton transmembrane transport
D2	0005739	cellular_component	mitochondrion
D2	0005743	cellular_component	mitochondrial inner membrane
D2	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D2	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D2	0032981	biological_process	mitochondrial respiratory chain complex I assembly
D2	0045271	cellular_component	respiratory chain complex I
D2	0072593	biological_process	reactive oxygen species metabolic process
D2	1902600	biological_process	proton transmembrane transport
D3	0005739	cellular_component	mitochondrion
D3	0005743	cellular_component	mitochondrial inner membrane
D3	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D3	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D3	0030964	cellular_component	NADH dehydrogenase complex
D3	0045271	cellular_component	respiratory chain complex I
D3	1902600	biological_process	proton transmembrane transport
D4	0003954	molecular_function	NADH dehydrogenase activity
D4	0005739	cellular_component	mitochondrion
D4	0005743	cellular_component	mitochondrial inner membrane
D4	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D4	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D4	0009060	biological_process	aerobic respiration
D4	0015990	biological_process	electron transport coupled proton transport
D4	0032981	biological_process	mitochondrial respiratory chain complex I assembly
D4	0042773	biological_process	ATP synthesis coupled electron transport
D4	0045271	cellular_component	respiratory chain complex I
D4	0048039	molecular_function	ubiquinone binding
D5	0003954	molecular_function	NADH dehydrogenase activity
D5	0005739	cellular_component	mitochondrion
D5	0005743	cellular_component	mitochondrial inner membrane
D5	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D5	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D5	0015990	biological_process	electron transport coupled proton transport
D5	0032981	biological_process	mitochondrial respiratory chain complex I assembly
D5	0042773	biological_process	ATP synthesis coupled electron transport
D5	0045271	cellular_component	respiratory chain complex I
D6	0005739	cellular_component	mitochondrion
D6	0005743	cellular_component	mitochondrial inner membrane
D6	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D6	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D6	0032981	biological_process	mitochondrial respiratory chain complex I assembly
D6	0045271	cellular_component	respiratory chain complex I
D6	1902600	biological_process	proton transmembrane transport
S1	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S1	0016020	cellular_component	membrane
S1	0016491	molecular_function	oxidoreductase activity
S1	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
S1	0042773	biological_process	ATP synthesis coupled electron transport
S1	0051536	molecular_function	iron-sulfur cluster binding
S2	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
S2	0048038	molecular_function	quinone binding
S2	0051287	molecular_function	NAD binding
S3	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S3	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
S4	0022900	biological_process	electron transport chain
S6	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
S7	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S7	0048038	molecular_function	quinone binding
S7	0051536	molecular_function	iron-sulfur cluster binding
S7	0051539	molecular_function	4 iron, 4 sulfur cluster binding
S8	0016020	cellular_component	membrane
S8	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
S8	0051539	molecular_function	4 iron, 4 sulfur cluster binding
V1	0005739	cellular_component	mitochondrion
V1	0005743	cellular_component	mitochondrial inner membrane
V1	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
V1	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
V1	0010181	molecular_function	FMN binding
V1	0046872	molecular_function	metal ion binding
V1	0051287	molecular_function	NAD binding
V1	0051539	molecular_function	4 iron, 4 sulfur cluster binding
V1	1902600	biological_process	proton transmembrane transport
V2	0016491	molecular_function	oxidoreductase activity
V3	0005739	cellular_component	mitochondrion
V3	0045271	cellular_component	respiratory chain complex I
a1	0046872	molecular_function	metal ion binding
a2	0004222	molecular_function	metalloendopeptidase activity
a2	0006508	biological_process	proteolysis
a2	0046872	molecular_function	metal ion binding
a3	0046872	molecular_function	metal ion binding
a4	0004222	molecular_function	metalloendopeptidase activity
a4	0006508	biological_process	proteolysis
a4	0046872	molecular_function	metal ion binding
b1	0005739	cellular_component	mitochondrion
b1	0005743	cellular_component	mitochondrial inner membrane
b1	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
b1	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
b1	0009055	molecular_function	electron transfer activity
b1	0016020	cellular_component	membrane
b1	0016491	molecular_function	oxidoreductase activity
b1	0022904	biological_process	respiratory electron transport chain
b1	0045275	cellular_component	respiratory chain complex III
b1	0046872	molecular_function	metal ion binding
b1	1902600	biological_process	proton transmembrane transport
b2	0005739	cellular_component	mitochondrion
b2	0005743	cellular_component	mitochondrial inner membrane
b2	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
b2	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
b2	0009055	molecular_function	electron transfer activity
b2	0016020	cellular_component	membrane
b2	0016491	molecular_function	oxidoreductase activity
b2	0022904	biological_process	respiratory electron transport chain
b2	0045275	cellular_component	respiratory chain complex III
b2	0046872	molecular_function	metal ion binding
b2	1902600	biological_process	proton transmembrane transport
c1	0009055	molecular_function	electron transfer activity
c1	0020037	molecular_function	heme binding
c2	0009055	molecular_function	electron transfer activity
c2	0020037	molecular_function	heme binding
d1	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
d1	0045275	cellular_component	respiratory chain complex III
d2	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
d2	0045275	cellular_component	respiratory chain complex III
f1	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
f1	0016020	cellular_component	membrane
f1	0051537	molecular_function	2 iron, 2 sulfur cluster binding
f2	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
f2	0016020	cellular_component	membrane
f2	0051537	molecular_function	2 iron, 2 sulfur cluster binding
h1	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
h2	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
i1	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
i1	0045275	cellular_component	respiratory chain complex III
i2	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
i2	0045275	cellular_component	respiratory chain complex III
q1	0005739	cellular_component	mitochondrion
q1	0005743	cellular_component	mitochondrial inner membrane
q1	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
q1	0045275	cellular_component	respiratory chain complex III
q2	0005739	cellular_component	mitochondrion
q2	0005743	cellular_component	mitochondrial inner membrane
q2	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
q2	0045275	cellular_component	respiratory chain complex III

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue HEM b1 401

Chain	Residue
b1	GLN44
b1	HIS182
b1	PHE183
b1	PRO186
b1	GLY48
b1	LEU51
b1	ARG80
b1	HIS83
b1	ALA87
b1	GLY130
b1	LEU133
b1	PRO134

site_id	AC2
Number of Residues	13
Details	binding site for residue HEM b1 402

Chain	Residue
b1	TRP31
b1	GLY34
b1	LEU37
b1	HIS97
b1	ARG100
b1	SER106
b1	TRP113
b1	GLY116
b1	LEU119
b1	HIS196
b1	LEU200
b1	SER205
b1	ASN206

site_id	AC3
Number of Residues	11
Details	binding site for residue HEC c1 501

Chain	Residue
c1	CYS37
c1	CYS40
c1	HIS41
c1	ASN105
c1	ALA108
c1	ARG120
c1	TYR126
c1	PHE152
c1	ILE157
c1	MET159
c1	PRO162

site_id	AC4
Number of Residues	8
Details	binding site for residue FES f1 501

Chain	Residue
f1	CYS139
f1	HIS141
f1	LEU142
f1	CYS144
f1	CYS158
f1	CYS160
f1	HIS161
f1	SER163

site_id	AC5
Number of Residues	10
Details	binding site for residue HEM b2 401

Chain	Residue
b2	GLY48
b2	ARG80
b2	HIS83
b2	ALA87
b2	GLY130
b2	PRO134
b2	HIS182
b2	PHE183
b2	PRO186
b2	ASN255

site_id	AC6
Number of Residues	12
Details	binding site for residue HEM b2 402

Chain	Residue
b2	TRP31
b2	GLY34
b2	LEU37
b2	HIS97
b2	ARG100
b2	SER106
b2	TRP113
b2	GLY116
b2	LEU119
b2	HIS196
b2	LEU200
b2	ASN206

site_id	AC7
Number of Residues	11
Details	binding site for residue HEC c2 501

Chain	Residue
c2	CYS37
c2	SER39
c2	CYS40
c2	HIS41
c2	ASN105
c2	ALA108
c2	PRO110
c2	PHE152
c2	ILE157
c2	GLY158
c2	MET159

site_id	AC8
Number of Residues	8
Details	binding site for residue FES f2 501

Chain	Residue
f2	CYS139
f2	HIS141
f2	LEU142
f2	CYS144
f2	CYS158
f2	HIS161
f2	SER163
f2	PRO175

site_id	AC9
Number of Residues	7
Details	binding site for residue PC1 D2 401

Chain	Residue
AK	TRP132
D2	ILE276
D2	ILE277
D4	TYR166
D4	SER191
D4	MET195
D4	ALA198

site_id	AD1
Number of Residues	10
Details	binding site for residue ZMP AB 101

Chain	Residue
B9	LYS51
B9	LEU62
B9	ALA66
AB	ASP43
AB	SER44
AB	LEU45
B9	GLN12
B9	ARG46
B9	PHE47
B9	HIS50

site_id	AD2
Number of Residues	9
Details	binding site for residue SF4 V1 500

Chain	Residue
V1	PRO203
V1	SER358
V1	CYS359
V1	GLY360
V1	GLN361
V1	CYS362
V1	CYS365
V1	THR403
V1	CYS405

site_id	AD3
Number of Residues	15
Details	binding site for residue FMN V1 501

Chain	Residue
V1	GLY67
V1	ARG68
V1	GLY69
V1	ALA71
V1	LYS78
V1	ASN96
V1	ASP98
V1	GLY100
V1	TYR184
V1	GLY187
V1	GLU188
V1	VAL222
V1	ALA223
V1	ASN224
V1	THR227

site_id	AD4
Number of Residues	8
Details	binding site for residue FES V2 300

Chain	Residue
V1	PRO102
V2	CYS103
V2	THR105
V2	PRO107
V2	CYS108
V2	CYS144
V2	ALA147
V2	CYS148

site_id	AD5
Number of Residues	10
Details	binding site for residue SF4 S1 801

Chain	Residue
S1	HIS101
S1	ASP104
S1	CYS105
S1	CYS108
S1	GLN110
S1	CYS114
S1	LEU116
S1	GLN117
S1	VAL205
S1	GLY206

site_id	AD6
Number of Residues	8
Details	binding site for residue SF4 S1 802

Chain	Residue
S1	CYS153
S1	ILE154
S1	CYS156
S1	THR157
S1	CYS159
S1	CYS203
S1	PRO204
S1	VAL205

site_id	AD7
Number of Residues	8
Details	binding site for residue FES S1 803

Chain	Residue
S1	CYS41
S1	TYR42
S1	GLY50
S1	ASN51
S1	CYS52
S1	ARG53
S1	CYS55
S1	CYS69

site_id	AD8
Number of Residues	9
Details	binding site for residue SF4 S7 300

Chain	Residue
S2	ARG105
S2	HIS190
S7	ALA53
S7	CYS54
S7	CYS55
S7	SER118
S7	CYS119
S7	CYS149
S7	PRO150

site_id	AD9
Number of Residues	11
Details	binding site for residue SF4 S8 201

Chain	Residue
S8	HIS65
S8	CYS87
S8	PRO88
S8	ILE92
S8	CYS116
S8	ILE117
S8	TYR118
S8	CYS119
S8	GLY120
S8	CYS122
S8	GLU133

site_id	AE1
Number of Residues	8
Details	binding site for residue SF4 S8 202

Chain	Residue
S8	CYS77
S8	ILE78
S8	ALA79
S8	CYS80
S8	LYS81
S8	CYS83
S8	CYS126
S8	ILE131

site_id	AE2
Number of Residues	5
Details	binding site for residue ZN S6 300

Chain	Residue
S6	CYS59
S6	HIS68
S6	VAL71
S6	CYS84
S6	CYS87

site_id	AE3
Number of Residues	16
Details	binding site for residue NDP A9 401

Chain	Residue
A9	GLY25
A9	ALA26
A9	THR27
A9	GLY28
A9	PHE29
A9	ARG50
A9	LEU94
A9	VAL95
A9	GLY96
A9	ARG97
A9	VAL109
A9	ILE132
A9	HIS134
A9	ASP170
A9	ILE171
A9	ARG177

site_id	AE4
Number of Residues	16
Details	binding site for Di-peptide ZMP AA 101 and SER AA 44

Chain	Residue
A6	LYS28
A6	ARG32
A6	TRP38
A6	MET65
A6	PHE66
A6	ASN69
A6	ALA70
A6	VAL72
A6	LEU81
A6	GLU88
AA	MET37
AA	ASP43
AA	LEU45
AA	ASP46
AA	GLN47
AA	VAL48

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM

Chain	Residue	Details
AB	ASP39-MET54

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI

Chain	Residue	Details
AB	ASP64-ILE76

site_id	PS00143
Number of Residues	24
Details	INSULINASE Insulinase family, zinc-binding region signature. GsryenfnnlGtSHLLRLAsSlTT

Chain	Residue	Details
a2	GLY54-THR77

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaVCP

Chain	Residue	Details
S8	CYS77-PRO88
S8	CYS116-PRO127

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
S2	LEU83-LYS94

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREiwDMFgvffanHpdlRrIL

Chain	Residue	Details
S3	GLU131-LEU152

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC

Chain	Residue	Details
S1	PRO38-CYS55

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
S1	CYS105-GLN117

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCIrF

Chain	Residue	Details
S1	ARG152-PHE162

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES

Chain	Residue	Details
V1	GLY180-SER195

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
V1	GLU357-GLY368

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpIaDAIKLFiKE

Chain	Residue	Details
D1	GLY44-GLU59

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLTEGEseLVs.G

Chain	Residue	Details
D1	PRO197-GLY210

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DklFTlieveCLGaCvnAP

Chain	Residue	Details
V2	ASP134-PRO152

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYvPgCPP

Chain	Residue	Details
S7	GLY135-PRO151

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	220
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
D2	PRO3-SER23
D2	ASP274-MET294
D2	LEU325-ILE345
D5	MET366-LEU386
D5	LEU413-GLY433
D5	LEU457-ILE477
D5	TYR485-SER505
D5	GLY582-LEU602
D2	HIS25-MET45
D2	SER67-MET87
D2	MET96-PRO116
D2	ILE122-LEU142
D2	ILE145-GLY165
D2	ILE178-PRO198
D2	MET200-MET220
D2	ALA237-LEU257

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: axial binding residue => ECO:0000250\|UniProtKB:P00157

Chain	Residue	Details
b1	HIS83
b1	HIS97
b1	HIS182
b1	HIS196
b2	HIS83
b2	HIS97
b2	HIS182
b2	HIS196

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P00157

Chain	Residue	Details
b1	HIS201
b2	HIS201

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)