Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0010506 | biological_process | regulation of autophagy |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0010506 | biological_process | regulation of autophagy |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 301 |
| Chain | Residue |
| A | ASN96 |
| A | GLY151 |
| A | ARG152 |
| A | HOH524 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | HOH425 |
| B | ARG153 |
| A | MET107 |
| A | LEU110 |
| A | SER111 |
| A | THR114 |
| A | HOH423 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | LYS237 |
| A | ARG261 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue CIT A 304 |
| Chain | Residue |
| A | GLY25 |
| A | ALA26 |
| A | ASP138 |
| A | LYS140 |
| A | ASP165 |
| A | PHE168 |
| A | EDO316 |
| A | HOH435 |
| A | HOH442 |
| A | HOH470 |
| A | HOH477 |
| A | HOH515 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 305 |
| Chain | Residue |
| A | LEU41 |
| A | TYR79 |
| A | GLU93 |
| A | TYR94 |
| A | GOL306 |
| A | HOH429 |
| A | HOH444 |
| B | ALA249 |
| B | PRO250 |
| B | GLN253 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | binding site for residue GOL A 306 |
| Chain | Residue |
| A | GLU73 |
| A | GLU93 |
| A | SER147 |
| A | PRO149 |
| A | ARG160 |
| A | LYS162 |
| A | GOL305 |
| A | HOH411 |
| A | HOH419 |
| B | ALA249 |
| B | GLN253 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 307 |
| Chain | Residue |
| A | GLU73 |
| A | HOH455 |
| B | VAL240 |
| B | PRO241 |
| B | THR242 |
| B | ILE243 |
| B | ARG252 |
| B | HOH433 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 308 |
| Chain | Residue |
| A | GLY97 |
| A | LEU146 |
| A | ARG152 |
| A | ILE159 |
| A | HOH407 |
| A | HOH422 |
| A | HOH488 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 309 |
| Chain | Residue |
| A | SER111 |
| A | GLU112 |
| A | HOH449 |
| A | HOH466 |
| A | HOH537 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 310 |
| Chain | Residue |
| A | SER248 |
| A | ALA249 |
| A | PRO250 |
| A | HOH457 |
| A | HOH571 |
| B | LYS13 |
| B | HIS35 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 311 |
| Chain | Residue |
| A | LYS50 |
| A | LYS51 |
| A | ASN52 |
| A | LEU53 |
| A | ALA54 |
| A | HOH402 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 312 |
| Chain | Residue |
| A | LYS62 |
| A | LYS65 |
| A | EDO317 |
| A | HOH426 |
| A | HOH556 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 313 |
| Chain | Residue |
| A | LYS201 |
| A | LYS264 |
| A | HOH456 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 314 |
| Chain | Residue |
| A | HIS72 |
| A | GLY124 |
| A | ARG127 |
| A | HOH401 |
| A | HOH406 |
| A | HOH447 |
| A | HOH511 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 315 |
| Chain | Residue |
| A | GLY133 |
| A | LEU172 |
| A | GLN173 |
| A | HOH430 |
| A | HOH461 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 316 |
| Chain | Residue |
| A | LYS140 |
| A | SER184 |
| A | CIT304 |
| A | HOH470 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 317 |
| Chain | Residue |
| A | LYS62 |
| A | LYS65 |
| A | ARG170 |
| A | TYR171 |
| A | EDO312 |
| A | HOH403 |
| A | HOH469 |
| site_id | AD9 |
| Number of Residues | 14 |
| Details | binding site for residue 34W A 318 |
| Chain | Residue |
| A | ILE22 |
| A | VAL30 |
| A | LYS32 |
| A | ALA44 |
| A | VAL76 |
| A | MET92 |
| A | GLU93 |
| A | TYR94 |
| A | CYS95 |
| A | LEU145 |
| A | HOH413 |
| A | HOH451 |
| A | HOH535 |
| B | HIS105 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 301 |
| Chain | Residue |
| A | LYS55 |
| B | GLN196 |
| B | HIS197 |
| B | HOH418 |
| site_id | AE2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 302 |
| Chain | Residue |
| A | GLN196 |
| A | HIS197 |
| B | LYS55 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 303 |
| Chain | Residue |
| B | LYS201 |
| B | HIS263 |
| B | LYS264 |
| B | HOH415 |
| B | HOH432 |
| site_id | AE4 |
| Number of Residues | 11 |
| Details | binding site for residue CIT B 304 |
| Chain | Residue |
| B | GLY25 |
| B | ALA26 |
| B | ASP138 |
| B | LYS140 |
| B | ASP165 |
| B | PHE168 |
| B | GOL306 |
| B | HOH429 |
| B | HOH449 |
| B | HOH498 |
| B | HOH536 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 305 |
| Chain | Residue |
| B | SER111 |
| B | GLU112 |
| B | ASP113 |
| B | HOH462 |
| site_id | AE6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 306 |
| Chain | Residue |
| B | PHE27 |
| B | ALA28 |
| B | LYS46 |
| B | GLU63 |
| B | ASP165 |
| B | GLY167 |
| B | CIT304 |
| B | HOH449 |
| B | HOH502 |
| site_id | AE7 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 307 |
| Chain | Residue |
| B | HIS130 |
| B | GLY133 |
| B | ILE134 |
| B | ILE135 |
| B | LEU172 |
| B | PHE269 |
| B | HOH402 |
| B | HOH416 |
| B | HOH455 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 308 |
| Chain | Residue |
| B | GLN196 |
| B | GLU234 |
| B | LYS237 |
| B | ARG261 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 309 |
| Chain | Residue |
| B | HIS130 |
| B | ASP268 |
| B | PHE269 |
| B | ASP270 |
| B | HOH405 |
| site_id | AF1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 310 |
| Chain | Residue |
| A | HIS105 |
| B | LYS32 |
| B | GLU42 |
| B | TYR94 |
| B | ASN96 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 311 |
| Chain | Residue |
| A | ARG153 |
| B | SER111 |
| B | THR114 |
| B | HOH419 |
| site_id | AF3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 312 |
| Chain | Residue |
| B | MET186 |
| B | TYR187 |
| B | GLN213 |
| B | LYS218 |
| B | ALA219 |
| B | GLN222 |
| site_id | AF4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 313 |
| Chain | Residue |
| B | LYS50 |
| B | LYS51 |
| B | ASN52 |
| B | LEU53 |
| B | ALA54 |
| B | HOH534 |
| site_id | AF5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 314 |
| Chain | Residue |
| B | PRO244 |
| B | ARG245 |
| B | GLU246 |
| site_id | AF6 |
| Number of Residues | 13 |
| Details | binding site for residue 34W B 315 |
| Chain | Residue |
| B | ILE22 |
| B | GLY23 |
| B | ALA44 |
| B | VAL76 |
| B | MET92 |
| B | GLU93 |
| B | TYR94 |
| B | CYS95 |
| B | GLY98 |
| B | LEU145 |
| B | ALA164 |
| B | 34W316 |
| B | HOH553 |
| site_id | AF7 |
| Number of Residues | 14 |
| Details | binding site for residue 34W B 316 |
| Chain | Residue |
| A | ALA106 |
| A | MET107 |
| A | HOH422 |
| B | GLY97 |
| B | GLY98 |
| B | ASP99 |
| B | ASP102 |
| B | TYR103 |
| B | ALA106 |
| B | MET107 |
| B | ARG153 |
| B | ALA154 |
| B | 34W315 |
| B | HOH516 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 25 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGHGAFAVVFkGrhraahdle.........VAVK |
| Chain | Residue | Details |
| A | ILE22-LYS46 | |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpqNILL |
| Chain | Residue | Details |
| A | ILE134-LEU146 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20921139","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O70405","evidenceCode":"ECO:0000250"}]} |
