6QAJ
Structure of the tripartite motif of KAP1/TRIM28
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003796 | molecular_function | lysozyme activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0009253 | biological_process | peptidoglycan catabolic process |
A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
A | 0016998 | biological_process | cell wall macromolecule catabolic process |
A | 0030430 | cellular_component | host cell cytoplasm |
A | 0031640 | biological_process | killing of cells of another organism |
A | 0042742 | biological_process | defense response to bacterium |
A | 0044659 | biological_process | viral release from host cell by cytolysis |
B | 0003796 | molecular_function | lysozyme activity |
B | 0008270 | molecular_function | zinc ion binding |
B | 0009253 | biological_process | peptidoglycan catabolic process |
B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
B | 0016998 | biological_process | cell wall macromolecule catabolic process |
B | 0030430 | cellular_component | host cell cytoplasm |
B | 0031640 | biological_process | killing of cells of another organism |
B | 0042742 | biological_process | defense response to bacterium |
B | 0044659 | biological_process | viral release from host cell by cytolysis |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue ZN A 500 |
Chain | Residue |
A | CYS65 |
A | CYS68 |
A | CYS88 |
A | CYS91 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue ZN A 501 |
Chain | Residue |
A | CYS83 |
A | HIS85 |
A | CYS117 |
A | VAL119 |
A | CYS120 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue ZN A 502 |
Chain | Residue |
A | CYS209 |
A | HIS212 |
A | CYS229 |
A | CYS232 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue ZN A 503 |
Chain | Residue |
A | CYS221 |
A | SER223 |
A | CYS224 |
A | HIS237 |
A | HIS240 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue ZN B 501 |
Chain | Residue |
B | CYS221 |
B | CYS224 |
B | HIS237 |
B | HIS240 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue ZN B 502 |
Chain | Residue |
B | CYS209 |
B | VAL211 |
B | HIS212 |
B | CYS229 |
B | CYS232 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue ZN B 503 |
Chain | Residue |
B | CYS65 |
B | CYS68 |
B | CYS88 |
B | CYS91 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue ZN B 504 |
Chain | Residue |
B | CYS83 |
B | HIS85 |
B | CYS117 |
B | CYS120 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 |
Chain | Residue | Details |
A | GLU-96 | |
B | GLU-96 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 |
Chain | Residue | Details |
A | ASP-87 | |
B | ASP-87 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:8266098 |
Chain | Residue | Details |
A | LEU-75 | |
A | PHE-3 | |
B | LEU-75 | |
B | PHE-3 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000303|PubMed:7831309 |
Chain | Residue | Details |
A | SER10 | |
A | ASN25 | |
B | SER10 | |
B | ASN25 |
site_id | SWS_FT_FI5 |
Number of Residues | 112 |
Details | ZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 |
Chain | Residue | Details |
A | CYS65-LYS121 | |
B | CYS65-LYS121 |
site_id | SWS_FT_FI6 |
Number of Residues | 94 |
Details | ZN_FING: B box-type 1; atypical => ECO:0000255|PROSITE-ProRule:PRU00024 |
Chain | Residue | Details |
A | ASP148-THR195 | |
B | ASP148-THR195 |
site_id | SWS_FT_FI7 |
Number of Residues | 82 |
Details | ZN_FING: B box-type 2 => ECO:0000255|PROSITE-ProRule:PRU00024 |
Chain | Residue | Details |
A | GLU204-LEU245 | |
B | GLU204-LEU245 |
site_id | SWS_FT_FI8 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00024 |
Chain | Residue | Details |
A | CYS153 | |
B | CYS156 | |
B | CYS177 | |
B | HIS181 | |
B | CYS209 | |
B | HIS212 | |
B | CYS232 | |
B | HIS237 | |
A | CYS156 | |
A | CYS177 | |
A | HIS181 | |
A | CYS209 | |
A | HIS212 | |
A | CYS232 | |
A | HIS237 | |
B | CYS153 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER138 | |
B | SER138 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q62318 |
Chain | Residue | Details |
A | LYS266 | |
B | LYS266 |
site_id | SWS_FT_FI11 |
Number of Residues | 4 |
Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS304 | |
A | LYS377 | |
B | LYS304 | |
B | LYS377 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS340 | |
B | LYS340 |
site_id | SWS_FT_FI13 |
Number of Residues | 8 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS127 | |
A | LYS272 | |
A | LYS407 | |
B | LYS127 | |
B | LYS272 | |
B | LYS407 |
site_id | SWS_FT_FI14 |
Number of Residues | 8 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS199 | |
A | LYS254 | |
A | LYS261 | |
A | LYS319 | |
B | LYS199 | |
B | LYS254 | |
B | LYS261 | |
B | LYS319 |
site_id | SWS_FT_FI15 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS304 | |
B | LYS304 |
site_id | SWS_FT_FI16 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447 |
Chain | Residue | Details |
A | LYS366 | |
B | LYS366 |
site_id | SWS_FT_FI17 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS377 | |
B | LYS377 |