Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6Q8I

Nterminal domain of human SMU1 in complex with human REDmid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0006397	biological_process	mRNA processing
A	0008380	biological_process	RNA splicing
A	0016607	cellular_component	nuclear speck
A	0071005	cellular_component	U2-type precatalytic spliceosome
A	0071011	cellular_component	precatalytic spliceosome
B	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
B	0000398	biological_process	mRNA splicing, via spliceosome
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0006397	biological_process	mRNA processing
B	0008380	biological_process	RNA splicing
B	0016607	cellular_component	nuclear speck
B	0071005	cellular_component	U2-type precatalytic spliceosome
B	0071011	cellular_component	precatalytic spliceosome
C	0000228	cellular_component	nuclear chromosome
C	0000278	biological_process	mitotic cell cycle
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0000922	cellular_component	spindle pole
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005681	cellular_component	spliceosomal complex
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0006397	biological_process	mRNA processing
C	0007094	biological_process	mitotic spindle assembly checkpoint signaling
C	0008380	biological_process	RNA splicing
C	0016607	cellular_component	nuclear speck
C	0034501	biological_process	protein localization to kinetochore
C	0042802	molecular_function	identical protein binding
C	0071005	cellular_component	U2-type precatalytic spliceosome
C	0097431	cellular_component	mitotic spindle pole
D	0000228	cellular_component	nuclear chromosome
D	0000278	biological_process	mitotic cell cycle
D	0000398	biological_process	mRNA splicing, via spliceosome
D	0000922	cellular_component	spindle pole
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005681	cellular_component	spliceosomal complex
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0006397	biological_process	mRNA processing
D	0007094	biological_process	mitotic spindle assembly checkpoint signaling
D	0008380	biological_process	RNA splicing
D	0016607	cellular_component	nuclear speck
D	0034501	biological_process	protein localization to kinetochore
D	0042802	molecular_function	identical protein binding
D	0071005	cellular_component	U2-type precatalytic spliceosome
D	0097431	cellular_component	mitotic spindle pole
E	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
E	0000398	biological_process	mRNA splicing, via spliceosome
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0006397	biological_process	mRNA processing
E	0008380	biological_process	RNA splicing
E	0016607	cellular_component	nuclear speck
E	0071005	cellular_component	U2-type precatalytic spliceosome
E	0071011	cellular_component	precatalytic spliceosome
F	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
F	0000398	biological_process	mRNA splicing, via spliceosome
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0006397	biological_process	mRNA processing
F	0008380	biological_process	RNA splicing
F	0016607	cellular_component	nuclear speck
F	0071005	cellular_component	U2-type precatalytic spliceosome
F	0071011	cellular_component	precatalytic spliceosome
G	0000228	cellular_component	nuclear chromosome
G	0000278	biological_process	mitotic cell cycle
G	0000398	biological_process	mRNA splicing, via spliceosome
G	0000922	cellular_component	spindle pole
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005681	cellular_component	spliceosomal complex
G	0005694	cellular_component	chromosome
G	0005737	cellular_component	cytoplasm
G	0005856	cellular_component	cytoskeleton
G	0006397	biological_process	mRNA processing
G	0007094	biological_process	mitotic spindle assembly checkpoint signaling
G	0008380	biological_process	RNA splicing
G	0016607	cellular_component	nuclear speck
G	0034501	biological_process	protein localization to kinetochore
G	0042802	molecular_function	identical protein binding
G	0071005	cellular_component	U2-type precatalytic spliceosome
G	0097431	cellular_component	mitotic spindle pole
H	0000228	cellular_component	nuclear chromosome
H	0000278	biological_process	mitotic cell cycle
H	0000398	biological_process	mRNA splicing, via spliceosome
H	0000922	cellular_component	spindle pole
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005681	cellular_component	spliceosomal complex
H	0005694	cellular_component	chromosome
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0006397	biological_process	mRNA processing
H	0007094	biological_process	mitotic spindle assembly checkpoint signaling
H	0008380	biological_process	RNA splicing
H	0016607	cellular_component	nuclear speck
H	0034501	biological_process	protein localization to kinetochore
H	0042802	molecular_function	identical protein binding
H	0071005	cellular_component	U2-type precatalytic spliceosome
H	0097431	cellular_component	mitotic spindle pole
I	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
I	0000398	biological_process	mRNA splicing, via spliceosome
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0006397	biological_process	mRNA processing
I	0008380	biological_process	RNA splicing
I	0016607	cellular_component	nuclear speck
I	0071005	cellular_component	U2-type precatalytic spliceosome
I	0071011	cellular_component	precatalytic spliceosome
J	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
J	0000398	biological_process	mRNA splicing, via spliceosome
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0006397	biological_process	mRNA processing
J	0008380	biological_process	RNA splicing
J	0016607	cellular_component	nuclear speck
J	0071005	cellular_component	U2-type precatalytic spliceosome
J	0071011	cellular_component	precatalytic spliceosome
K	0000228	cellular_component	nuclear chromosome
K	0000278	biological_process	mitotic cell cycle
K	0000398	biological_process	mRNA splicing, via spliceosome
K	0000922	cellular_component	spindle pole
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005681	cellular_component	spliceosomal complex
K	0005694	cellular_component	chromosome
K	0005737	cellular_component	cytoplasm
K	0005856	cellular_component	cytoskeleton
K	0006397	biological_process	mRNA processing
K	0007094	biological_process	mitotic spindle assembly checkpoint signaling
K	0008380	biological_process	RNA splicing
K	0016607	cellular_component	nuclear speck
K	0034501	biological_process	protein localization to kinetochore
K	0042802	molecular_function	identical protein binding
K	0071005	cellular_component	U2-type precatalytic spliceosome
K	0097431	cellular_component	mitotic spindle pole
L	0000228	cellular_component	nuclear chromosome
L	0000278	biological_process	mitotic cell cycle
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0000922	cellular_component	spindle pole
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005681	cellular_component	spliceosomal complex
L	0005694	cellular_component	chromosome
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0006397	biological_process	mRNA processing
L	0007094	biological_process	mitotic spindle assembly checkpoint signaling
L	0008380	biological_process	RNA splicing
L	0016607	cellular_component	nuclear speck
L	0034501	biological_process	protein localization to kinetochore
L	0042802	molecular_function	identical protein binding
L	0071005	cellular_component	U2-type precatalytic spliceosome
L	0097431	cellular_component	mitotic spindle pole
M	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
M	0000398	biological_process	mRNA splicing, via spliceosome
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0006397	biological_process	mRNA processing
M	0008380	biological_process	RNA splicing
M	0016607	cellular_component	nuclear speck
M	0071005	cellular_component	U2-type precatalytic spliceosome
M	0071011	cellular_component	precatalytic spliceosome
N	0000381	biological_process	regulation of alternative mRNA splicing, via spliceosome
N	0000398	biological_process	mRNA splicing, via spliceosome
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0006397	biological_process	mRNA processing
N	0008380	biological_process	RNA splicing
N	0016607	cellular_component	nuclear speck
N	0071005	cellular_component	U2-type precatalytic spliceosome
N	0071011	cellular_component	precatalytic spliceosome
O	0000228	cellular_component	nuclear chromosome
O	0000278	biological_process	mitotic cell cycle
O	0000398	biological_process	mRNA splicing, via spliceosome
O	0000922	cellular_component	spindle pole
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005681	cellular_component	spliceosomal complex
O	0005694	cellular_component	chromosome
O	0005737	cellular_component	cytoplasm
O	0005856	cellular_component	cytoskeleton
O	0006397	biological_process	mRNA processing
O	0007094	biological_process	mitotic spindle assembly checkpoint signaling
O	0008380	biological_process	RNA splicing
O	0016607	cellular_component	nuclear speck
O	0034501	biological_process	protein localization to kinetochore
O	0042802	molecular_function	identical protein binding
O	0071005	cellular_component	U2-type precatalytic spliceosome
O	0097431	cellular_component	mitotic spindle pole
P	0000228	cellular_component	nuclear chromosome
P	0000278	biological_process	mitotic cell cycle
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0000922	cellular_component	spindle pole
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005681	cellular_component	spliceosomal complex
P	0005694	cellular_component	chromosome
P	0005737	cellular_component	cytoplasm
P	0005856	cellular_component	cytoskeleton
P	0006397	biological_process	mRNA processing
P	0007094	biological_process	mitotic spindle assembly checkpoint signaling
P	0008380	biological_process	RNA splicing
P	0016607	cellular_component	nuclear speck
P	0034501	biological_process	protein localization to kinetochore
P	0042802	molecular_function	identical protein binding
P	0071005	cellular_component	U2-type precatalytic spliceosome
P	0097431	cellular_component	mitotic spindle pole

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVTGsvDgFIEVWNF

Chain	Residue	Details
A	LEU229-PHE243
A	ILE364-MET378

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
K	LYS98
D	LYS98
G	LYS98
H	LYS98
L	LYS98
O	LYS98
P	LYS98
N	SER2

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:Q9Z1M8

Chain	Residue	Details
K	LYS137
J	LYS379
M	LYS379
N	LYS379
D	LYS137
G	LYS137
H	LYS137
L	LYS137
O	LYS137
P	LYS137
I	LYS379

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
K	SER287
H	SER287
H	SER417
H	SER536
L	SER287
L	SER417
L	SER536
O	SER287
O	SER417
O	SER536
P	SER287
K	SER417
P	SER417
P	SER536
K	SER536
D	SER287
D	SER417
D	SER536
G	SER287
G	SER417
G	SER536

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648

Chain	Residue	Details
K	SER460
D	SER460
G	SER460
H	SER460
L	SER460
O	SER460
P	SER460

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:17525332

Chain	Residue	Details
K	THR485
D	THR485
G	THR485
H	THR485
L	THR485
O	THR485
P	THR485

site_id	SWS_FT_FI6
Number of Residues	14
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
K	LYS151
K	LYS501
K	LYS509
K	LYS541
K	LYS543
K	LYS553
D	LYS151
D	LYS310
D	LYS331
D	LYS386
D	LYS388
D	LYS404
D	LYS408
D	LYS496
D	LYS501
D	LYS509
D	LYS541
D	LYS543
D	LYS553
G	LYS151
K	LYS310
G	LYS310
G	LYS331
G	LYS386
G	LYS388
G	LYS404
G	LYS408
G	LYS496
G	LYS501
G	LYS509
K	LYS331
G	LYS541
G	LYS543
G	LYS553
H	LYS151
H	LYS310
H	LYS331
H	LYS386
H	LYS388
H	LYS404
K	LYS386
H	LYS408
H	LYS496
H	LYS501
H	LYS509
H	LYS541
H	LYS543
H	LYS553
L	LYS151
L	LYS310
K	LYS388
L	LYS331
L	LYS386
L	LYS388
L	LYS404
L	LYS408
L	LYS496
L	LYS501
L	LYS509
L	LYS541
L	LYS543
K	LYS404
L	LYS553
O	LYS151
O	LYS310
O	LYS331
O	LYS386
O	LYS388
O	LYS404
O	LYS408
O	LYS496
K	LYS408
O	LYS501
O	LYS509
O	LYS541
O	LYS543
O	LYS553
P	LYS151
P	LYS310
P	LYS331
P	LYS386
K	LYS496
P	LYS388
P	LYS404
P	LYS408
P	LYS496
P	LYS501
P	LYS509
P	LYS541
P	LYS543
P	LYS553

site_id	SWS_FT_FI7
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:25218447, ECO:0007744\|PubMed:28112733

Chain	Residue	Details
K	LYS544
D	LYS544
G	LYS544
H	LYS544
L	LYS544
O	LYS544
P	LYS544

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)