6Q2S

Cryo-EM structure of RET/GFRa3/ARTN extracellular complex. The 3D refinement was applied with C2 symmetry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000794	cellular_component	condensed nuclear chromosome
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005940	cellular_component	septin ring
A	0008083	molecular_function	growth factor activity
A	0016925	biological_process	protein sumoylation
A	0030116	molecular_function	glial cell-derived neurotrophic factor receptor binding
A	0030971	molecular_function	receptor tyrosine kinase binding
A	0031386	molecular_function	protein tag activity
A	0042802	molecular_function	identical protein binding
A	0044389	molecular_function	ubiquitin-like protein ligase binding
B	0000794	cellular_component	condensed nuclear chromosome
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005940	cellular_component	septin ring
B	0008083	molecular_function	growth factor activity
B	0016925	biological_process	protein sumoylation
B	0030116	molecular_function	glial cell-derived neurotrophic factor receptor binding
B	0030971	molecular_function	receptor tyrosine kinase binding
B	0031386	molecular_function	protein tag activity
B	0042802	molecular_function	identical protein binding
B	0044389	molecular_function	ubiquitin-like protein ligase binding
C	0001764	biological_process	neuron migration
C	0005102	molecular_function	signaling receptor binding
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0007165	biological_process	signal transduction
C	0007399	biological_process	nervous system development
C	0007411	biological_process	axon guidance
C	0007422	biological_process	peripheral nervous system development
C	0008046	molecular_function	axon guidance receptor activity
C	0009897	cellular_component	external side of plasma membrane
C	0016167	molecular_function	glial cell-derived neurotrophic factor receptor activity
C	0019898	cellular_component	extrinsic component of membrane
C	0035860	biological_process	glial cell-derived neurotrophic factor receptor signaling pathway
C	0038023	molecular_function	signaling receptor activity
C	0043235	cellular_component	receptor complex
C	0048485	biological_process	sympathetic nervous system development
C	0048666	biological_process	neuron development
C	0098552	cellular_component	side of membrane
D	0001764	biological_process	neuron migration
D	0005102	molecular_function	signaling receptor binding
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0007165	biological_process	signal transduction
D	0007399	biological_process	nervous system development
D	0007411	biological_process	axon guidance
D	0007422	biological_process	peripheral nervous system development
D	0008046	molecular_function	axon guidance receptor activity
D	0009897	cellular_component	external side of plasma membrane
D	0016167	molecular_function	glial cell-derived neurotrophic factor receptor activity
D	0019898	cellular_component	extrinsic component of membrane
D	0035860	biological_process	glial cell-derived neurotrophic factor receptor signaling pathway
D	0038023	molecular_function	signaling receptor activity
D	0043235	cellular_component	receptor complex
D	0048485	biological_process	sympathetic nervous system development
D	0048666	biological_process	neuron development
D	0098552	cellular_component	side of membrane
E	0005509	molecular_function	calcium ion binding
E	0007156	biological_process	homophilic cell adhesion via plasma membrane adhesion molecules
E	0016020	cellular_component	membrane
F	0005509	molecular_function	calcium ion binding
F	0007156	biological_process	homophilic cell adhesion via plasma membrane adhesion molecules
F	0016020	cellular_component	membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16765900","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GH0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	228
Details	Region: {"description":"Cadherin-like region 3 (CLD3)","evidences":[{"source":"PubMed","id":"11445581","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31535977","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25242331","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4UX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Q2J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31535977","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6Q2J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Breakpoint for translocation to form the TRIM27/RET oncogene","evidences":[{"source":"PubMed","id":"3037315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"20473317","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---