Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide WMH C 101 and ALA C 3 |
| Chain | Residue |
| A | TRP761 |
| A | GLY762 |
| C | GLY1 |
| C | ARG2 |
| C | TYR4 |
| C | PRO9 |
| C | ILE10 |
| C | ALA11 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for Di-peptide WMH C 101 and ALA C 11 |
| Chain | Residue |
| C | ALA3 |
| C | PRO9 |
| C | ILE10 |
| C | PHE12 |
| C | ARG2 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide WMH D 101 and ALA D 11 |
| Chain | Residue |
| D | ARG2 |
| D | ALA3 |
| D | PRO9 |
| D | ILE10 |
| D | PHE12 |
| D | HOH204 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide WMH D 101 and ALA D 3 |
| Chain | Residue |
| B | TRP761 |
| B | GLY762 |
| D | GLY1 |
| D | ARG2 |
| D | TYR4 |
| D | LYS5 |
| D | PRO9 |
| D | ILE10 |
| D | ALA11 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| A | LEU599-CYS604 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV |
| Chain | Residue | Details |
| A | ASP735-VAL746 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 454 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Charge relay system"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"9201958","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 26 |
| Details | Peptide: {"description":"Trypsin inhibitor 1","featureId":"PRO_0000042673"} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Reactive bond","evidences":[{"source":"UniProtKB","id":"P81705","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Cyclopeptide (Gly-Asp)"} |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 425 |
| Chain | Residue | Details |
| A | HIS603 | proton shuttle (general acid/base) |
| A | ASP646 | electrostatic stabiliser, modifies pKa |
| A | SER741 | covalent catalysis, proton shuttle (general acid/base) |
| A | GLY742 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 425 |
| Chain | Residue | Details |
| B | HIS603 | proton shuttle (general acid/base) |
| B | ASP646 | electrostatic stabiliser, modifies pKa |
| B | SER741 | covalent catalysis, proton shuttle (general acid/base) |
| B | GLY742 | electrostatic stabiliser |
