6PZQ

Structure of the human respiratory syncytial virus M2-1 protein in complex with a short positive-sense gene-end RNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0005198	molecular_function	structural molecule activity
A	0005515	molecular_function	protein binding
A	0019083	biological_process	viral transcription
A	0030430	cellular_component	host cell cytoplasm
A	0031564	biological_process	transcription antitermination
A	0042025	cellular_component	host cell nucleus
A	0044423	cellular_component	virion component
A	0046782	biological_process	regulation of viral transcription
A	0046872	molecular_function	metal ion binding
A	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
B	0003723	molecular_function	RNA binding
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0019083	biological_process	viral transcription
B	0030430	cellular_component	host cell cytoplasm
B	0031564	biological_process	transcription antitermination
B	0042025	cellular_component	host cell nucleus
B	0044423	cellular_component	virion component
B	0046782	biological_process	regulation of viral transcription
B	0046872	molecular_function	metal ion binding
B	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
C	0003723	molecular_function	RNA binding
C	0005198	molecular_function	structural molecule activity
C	0005515	molecular_function	protein binding
C	0019083	biological_process	viral transcription
C	0030430	cellular_component	host cell cytoplasm
C	0031564	biological_process	transcription antitermination
C	0042025	cellular_component	host cell nucleus
C	0044423	cellular_component	virion component
C	0046782	biological_process	regulation of viral transcription
C	0046872	molecular_function	metal ion binding
C	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
D	0003723	molecular_function	RNA binding
D	0005198	molecular_function	structural molecule activity
D	0005515	molecular_function	protein binding
D	0019083	biological_process	viral transcription
D	0030430	cellular_component	host cell cytoplasm
D	0031564	biological_process	transcription antitermination
D	0042025	cellular_component	host cell nucleus
D	0044423	cellular_component	virion component
D	0046782	biological_process	regulation of viral transcription
D	0046872	molecular_function	metal ion binding
D	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 201

Chain	Residue
A	CYS7
A	CYS15
A	CYS21
A	HIS25

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN B 201

Chain	Residue
B	CYS7
B	CYS15
B	CYS21
B	HIS25

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN C 201

Chain	Residue
C	CYS15
C	CYS21
C	HIS25
C	CYS7

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN D 201

Chain	Residue
D	CYS7
D	CYS15
D	CYS21
D	HIS25

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	108
Details	ZN_FING: C3H1-type => ECO:0000255|PROSITE-ProRule:PRU00723, ECO:0000269|PubMed:24434552, ECO:0000269|PubMed:32697936

Chain	Residue	Details
A	MET1-PHE28
B	MET1-PHE28
C	MET1-PHE28
D	MET1-PHE28

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	SITE: Involved in RNA-binding => ECO:0000269|PubMed:32697936

Chain	Residue	Details
A	LYS8
B	ARG151
C	LYS8
C	PHE9
C	PHE23
C	LYS92
C	ARG151
D	LYS8
D	PHE9
D	PHE23
D	LYS92
A	PHE9
D	ARG151
A	PHE23
A	LYS92
A	ARG151
B	LYS8
B	PHE9
B	PHE23
B	LYS92

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphoserine; by host => ECO:0000269|PubMed:11711610

Chain	Residue	Details
A	SER58
A	SER61
B	SER58
B	SER61
C	SER58
C	SER61
D	SER58
D	SER61

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