6PYP

Binary Complex of Human Glycerol 3-Phosphate Dehydrogenase, R269A mutant

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0006072	biological_process	glycerol-3-phosphate metabolic process
A	0006094	biological_process	gluconeogenesis
A	0006127	biological_process	glycerol-3-phosphate shuttle
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0042803	molecular_function	protein homodimerization activity
A	0045821	biological_process	positive regulation of glycolytic process
A	0046168	biological_process	glycerol-3-phosphate catabolic process
A	0047952	molecular_function	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A	0051287	molecular_function	NAD binding
A	0070062	cellular_component	extracellular exosome
A	0071320	biological_process	cellular response to cAMP
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0141152	molecular_function	glycerol-3-phosphate dehydrogenase (NAD+) activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0006072	biological_process	glycerol-3-phosphate metabolic process
B	0006094	biological_process	gluconeogenesis
B	0006127	biological_process	glycerol-3-phosphate shuttle
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0042803	molecular_function	protein homodimerization activity
B	0045821	biological_process	positive regulation of glycolytic process
B	0046168	biological_process	glycerol-3-phosphate catabolic process
B	0047952	molecular_function	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B	0051287	molecular_function	NAD binding
B	0070062	cellular_component	extracellular exosome
B	0071320	biological_process	cellular response to cAMP
B	0071356	biological_process	cellular response to tumor necrosis factor
B	0141152	molecular_function	glycerol-3-phosphate dehydrogenase (NAD+) activity

PDBデータベースに由来する情報

site_id	AC1
残基数	19
詳細	binding site for residue NAD A 401

鎖名	残基
A	SER11
A	ILE119
A	LYS120
A	ASN151
A	ILE152
A	ALA153
A	HOH502
A	HOH503
A	HOH577
A	HOH596
A	HOH641
A	GLY12
A	ASN13
A	TRP14
A	PHE41
A	VAL93
A	PRO94
A	PHE97
A	LEU118

---

site_id	AC2
残基数	4
詳細	binding site for residue PO4 A 402

鎖名	残基
A	LYS240
A	SER249
A	HOH505
A	HOH567

---

site_id	AC3
残基数	8
詳細	binding site for residue 3SY A 403

鎖名	残基
A	LEU129
A	LYS130
A	LEU131
A	GLU134
A	ASP195
A	PHE242
A	CYS243
A	SER244

---

site_id	AC4
残基数	5
詳細	binding site for residue POP B 401

鎖名	残基
B	GLY12
B	ASN13
B	TRP14
B	PRO94
B	HOH534

---

site_id	AC5
残基数	6
詳細	binding site for residue K B 402

鎖名	残基
B	ALA26
B	ALA27
B	LEU29
B	PHE32
B	HOH526
B	HOH614

---

UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id	PS00957
残基数	22
詳細	NAD_G3PDH NAD-dependent glycerol-3-phosphate dehydrogenase signature. GALKNVVAvGaGFcdGLgFGdN

鎖名	残基	詳細
A	GLY201-ASN222

---

SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	2
詳細	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000305"}]}

鎖名

残基

詳細

---

site_id	SWS_FT_FI2
残基数	21
詳細	Binding site: {"evidences":[{"source":"PubMed","id":"16460752","evidenceCode":"ECO:0000269"}]}

鎖名

残基

詳細

---

site_id	SWS_FT_FI3
残基数	4
詳細	Binding site: {}

鎖名

残基

詳細

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site_id	SWS_FT_FI4
残基数	2
詳細	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

鎖名

残基

詳細

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site_id	SWS_FT_FI5
残基数	2
詳細	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P13707","evidenceCode":"ECO:0000250"}]}

鎖名

残基

詳細

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site_id	SWS_FT_FI6
残基数	2
詳細	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"O35077","evidenceCode":"ECO:0000250"}]}

鎖名

残基

詳細

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