6PY8
Crystal structure of the RBPJ-NOTCH1-NRARP ternary complex bound to DNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0001569 | biological_process | branching involved in blood vessel morphogenesis |
| B | 0002043 | biological_process | blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| B | 0005515 | molecular_function | protein binding |
| B | 0007219 | biological_process | Notch signaling pathway |
| B | 0045746 | biological_process | negative regulation of Notch signaling pathway |
| B | 0090263 | biological_process | positive regulation of canonical Wnt signaling pathway |
| C | 0000978 | molecular_function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| C | 0001228 | molecular_function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| E | 0000978 | molecular_function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| E | 0001228 | molecular_function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| E | 0003677 | molecular_function | DNA binding |
| E | 0003700 | molecular_function | DNA-binding transcription factor activity |
| E | 0005634 | cellular_component | nucleus |
| E | 0006355 | biological_process | regulation of DNA-templated transcription |
| E | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| G | 0001569 | biological_process | branching involved in blood vessel morphogenesis |
| G | 0002043 | biological_process | blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| G | 0005515 | molecular_function | protein binding |
| G | 0007219 | biological_process | Notch signaling pathway |
| G | 0045746 | biological_process | negative regulation of Notch signaling pathway |
| G | 0090263 | biological_process | positive regulation of canonical Wnt signaling pathway |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 58 |
| Details | Repeat: {"description":"ANK 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 180 |
| Details | Domain: {"description":"IPT/TIG"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"16530044","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P31266","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 58 |
| Details | Repeat: {"description":"ANK 1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 60 |
| Details | Repeat: {"description":"ANK 2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 58 |
| Details | Repeat: {"description":"ANK 3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 58 |
| Details | Repeat: {"description":"ANK 4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 58 |
| Details | Repeat: {"description":"ANK 5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 32 |
| Details | Region: {"description":"HIF1AN-binding","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"(3S)-3-hydroxyasparagine; by HIF1AN; partial","evidences":[{"source":"PubMed","id":"17573339","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"(3S)-3-hydroxyasparagine; by HIF1AN","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q01705","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
