6PY8

Crystal structure of the RBPJ-NOTCH1-NRARP ternary complex bound to DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0001569	biological_process	branching involved in blood vessel morphogenesis
B	0001935	biological_process	endothelial cell proliferation
B	0001938	biological_process	positive regulation of endothelial cell proliferation
B	0002040	biological_process	sprouting angiogenesis
B	0002043	biological_process	blood vessel endothelial cell proliferation involved in sprouting angiogenesis
B	0005515	molecular_function	protein binding
B	0007219	biological_process	Notch signaling pathway
B	0022407	biological_process	regulation of cell-cell adhesion
B	0030217	biological_process	T cell differentiation
B	0032525	biological_process	somite rostral/caudal axis specification
B	0045581	biological_process	negative regulation of T cell differentiation
B	0045746	biological_process	negative regulation of Notch signaling pathway
B	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
B	0101023	biological_process	vascular endothelial cell proliferation
B	1905564	biological_process	positive regulation of vascular endothelial cell proliferation
C	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
C	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
E	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0005634	cellular_component	nucleus
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0001569	biological_process	branching involved in blood vessel morphogenesis
G	0001935	biological_process	endothelial cell proliferation
G	0001938	biological_process	positive regulation of endothelial cell proliferation
G	0002040	biological_process	sprouting angiogenesis
G	0002043	biological_process	blood vessel endothelial cell proliferation involved in sprouting angiogenesis
G	0005515	molecular_function	protein binding
G	0007219	biological_process	Notch signaling pathway
G	0022407	biological_process	regulation of cell-cell adhesion
G	0030217	biological_process	T cell differentiation
G	0032525	biological_process	somite rostral/caudal axis specification
G	0045581	biological_process	negative regulation of T cell differentiation
G	0045746	biological_process	negative regulation of Notch signaling pathway
G	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
G	0101023	biological_process	vascular endothelial cell proliferation
G	1905564	biological_process	positive regulation of vascular endothelial cell proliferation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q01705

Chain	Residue	Details
F	THR1862
K	THR1862

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: (3S)-3-hydroxyasparagine; by HIF1AN; partial => ECO:0000269|PubMed:17573339

Chain	Residue	Details
F	ASN1956
K	ASN1956

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: (3S)-3-hydroxyasparagine; by HIF1AN => ECO:0000250

Chain	Residue	Details
F	ASN2023
K	ASN2023

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site_id	SWS_FT_FI4
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q01705

Chain	Residue	Details
F	LYS1759
K	LYS1759

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