6PWZ
Crystal structure of human uridine-cytidine kinase 2 complexed with 2'-azidocytidine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004849 | molecular_function | uridine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0007631 | biological_process | feeding behavior |
| A | 0009224 | biological_process | CMP biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043771 | molecular_function | cytidine kinase activity |
| A | 0044206 | biological_process | UMP salvage |
| A | 0044211 | biological_process | CTP salvage |
| A | 0048678 | biological_process | response to axon injury |
| A | 0071453 | biological_process | cellular response to oxygen levels |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004849 | molecular_function | uridine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0007631 | biological_process | feeding behavior |
| B | 0009224 | biological_process | CMP biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043771 | molecular_function | cytidine kinase activity |
| B | 0044206 | biological_process | UMP salvage |
| B | 0044211 | biological_process | CTP salvage |
| B | 0048678 | biological_process | response to axon injury |
| B | 0071453 | biological_process | cellular response to oxygen levels |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004849 | molecular_function | uridine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0007631 | biological_process | feeding behavior |
| C | 0009224 | biological_process | CMP biosynthetic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0043771 | molecular_function | cytidine kinase activity |
| C | 0044206 | biological_process | UMP salvage |
| C | 0044211 | biological_process | CTP salvage |
| C | 0048678 | biological_process | response to axon injury |
| C | 0071453 | biological_process | cellular response to oxygen levels |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004849 | molecular_function | uridine kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0007631 | biological_process | feeding behavior |
| D | 0009224 | biological_process | CMP biosynthetic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0016740 | molecular_function | transferase activity |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0043771 | molecular_function | cytidine kinase activity |
| D | 0044206 | biological_process | UMP salvage |
| D | 0044211 | biological_process | CTP salvage |
| D | 0048678 | biological_process | response to axon injury |
| D | 0071453 | biological_process | cellular response to oxygen levels |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0004849 | molecular_function | uridine kinase activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0007631 | biological_process | feeding behavior |
| E | 0009224 | biological_process | CMP biosynthetic process |
| E | 0016301 | molecular_function | kinase activity |
| E | 0016740 | molecular_function | transferase activity |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0043771 | molecular_function | cytidine kinase activity |
| E | 0044206 | biological_process | UMP salvage |
| E | 0044211 | biological_process | CTP salvage |
| E | 0048678 | biological_process | response to axon injury |
| E | 0071453 | biological_process | cellular response to oxygen levels |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0004849 | molecular_function | uridine kinase activity |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0007631 | biological_process | feeding behavior |
| F | 0009224 | biological_process | CMP biosynthetic process |
| F | 0016301 | molecular_function | kinase activity |
| F | 0016740 | molecular_function | transferase activity |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0043771 | molecular_function | cytidine kinase activity |
| F | 0044206 | biological_process | UMP salvage |
| F | 0044211 | biological_process | CTP salvage |
| F | 0048678 | biological_process | response to axon injury |
| F | 0071453 | biological_process | cellular response to oxygen levels |
| G | 0000166 | molecular_function | nucleotide binding |
| G | 0004849 | molecular_function | uridine kinase activity |
| G | 0005524 | molecular_function | ATP binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005829 | cellular_component | cytosol |
| G | 0007631 | biological_process | feeding behavior |
| G | 0009224 | biological_process | CMP biosynthetic process |
| G | 0016301 | molecular_function | kinase activity |
| G | 0016740 | molecular_function | transferase activity |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0043771 | molecular_function | cytidine kinase activity |
| G | 0044206 | biological_process | UMP salvage |
| G | 0044211 | biological_process | CTP salvage |
| G | 0048678 | biological_process | response to axon injury |
| G | 0071453 | biological_process | cellular response to oxygen levels |
| H | 0000166 | molecular_function | nucleotide binding |
| H | 0004849 | molecular_function | uridine kinase activity |
| H | 0005524 | molecular_function | ATP binding |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005829 | cellular_component | cytosol |
| H | 0007631 | biological_process | feeding behavior |
| H | 0009224 | biological_process | CMP biosynthetic process |
| H | 0016301 | molecular_function | kinase activity |
| H | 0016740 | molecular_function | transferase activity |
| H | 0042802 | molecular_function | identical protein binding |
| H | 0043771 | molecular_function | cytidine kinase activity |
| H | 0044206 | biological_process | UMP salvage |
| H | 0044211 | biological_process | CTP salvage |
| H | 0048678 | biological_process | response to axon injury |
| H | 0071453 | biological_process | cellular response to oxygen levels |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 301 |
| Chain | Residue |
| A | GLY28 |
| A | ALA30 |
| A | SER31 |
| A | GLY32 |
| A | LYS33 |
| A | SER34 |
| A | ARG169 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | THR200 |
| A | LYS202 |
| A | TYR203 |
| A | TYR141 |
| A | ARG146 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 303 |
| Chain | Residue |
| A | ASP156 |
| A | ASP158 |
| A | PRO209 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 304 |
| Chain | Residue |
| A | PHE81 |
| A | ASP87 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 305 |
| Chain | Residue |
| A | ASN91 |
| A | LEU138 |
| A | SER142 |
| A | VAL145 |
| B | GLU92 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 306 |
| Chain | Residue |
| A | PHE81 |
| A | PHE83 |
| A | ASP84 |
| A | GLN184 |
| A | PHE188 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 307 |
| Chain | Residue |
| A | SER63 |
| A | TYR65 |
| A | ASP90 |
| A | LEU93 |
| A | PRO110 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 B 301 |
| Chain | Residue |
| B | GLY28 |
| B | ALA30 |
| B | SER31 |
| B | GLY32 |
| B | LYS33 |
| B | SER34 |
| B | ARG169 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 302 |
| Chain | Residue |
| B | ASP156 |
| B | ASP158 |
| B | PRO209 |
| B | HOH406 |
| H | LYS201 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue GOL B 303 |
| Chain | Residue |
| B | SER164 |
| C | GLU179 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 304 |
| Chain | Residue |
| B | SER70 |
| D | HIS85 |
| D | ASP87 |
| D | TYR141 |
| D | GLU195 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 C 301 |
| Chain | Residue |
| C | GLY28 |
| C | ALA30 |
| C | SER31 |
| C | GLY32 |
| C | LYS33 |
| C | SER34 |
| C | ARG169 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 302 |
| Chain | Residue |
| C | GLN61 |
| C | PRO86 |
| C | PHE89 |
| C | ASN91 |
| C | LEU138 |
| C | SER142 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 303 |
| Chain | Residue |
| C | LEU43 |
| C | ASN219 |
| C | VAL222 |
| C | GLN226 |
| site_id | AD6 |
| Number of Residues | 1 |
| Details | binding site for residue GOL C 304 |
| Chain | Residue |
| C | SER164 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 305 |
| Chain | Residue |
| C | THR29 |
| C | ASP62 |
| C | TYR65 |
| C | ASP84 |
| C | PHE89 |
| C | ILE137 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 D 301 |
| Chain | Residue |
| D | ALA30 |
| D | SER31 |
| D | GLY32 |
| D | LYS33 |
| D | SER34 |
| D | ARG169 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 302 |
| Chain | Residue |
| D | GLN61 |
| D | ASN91 |
| D | ILE94 |
| D | LEU138 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 303 |
| Chain | Residue |
| D | ILE58 |
| D | LEU59 |
| D | SER60 |
| D | SER63 |
| site_id | AE2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL D 304 |
| Chain | Residue |
| D | PHE81 |
| D | PHE83 |
| D | ASP84 |
| D | ARG166 |
| D | GLN184 |
| D | PHE188 |
| D | P6D308 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 305 |
| Chain | Residue |
| D | GLN108 |
| D | LYS96 |
| D | GLU100 |
| D | VAL107 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL D 306 |
| Chain | Residue |
| D | ILE186 |
| G | SER164 |
| G | LEU168 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 307 |
| Chain | Residue |
| D | ASP156 |
| D | ALA159 |
| D | LEU198 |
| D | LYS201 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue P6D D 308 |
| Chain | Residue |
| D | TYR65 |
| D | ARG174 |
| D | GOL304 |
| D | HOH402 |
| E | SER172 |
| E | GLY175 |
| site_id | AE7 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 E 301 |
| Chain | Residue |
| E | ALA30 |
| E | SER31 |
| E | GLY32 |
| E | LYS33 |
| E | SER34 |
| E | ARG169 |
| E | HOH402 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue GOL E 302 |
| Chain | Residue |
| E | TYR141 |
| E | ARG146 |
| E | LYS202 |
| E | TYR203 |
| site_id | AE9 |
| Number of Residues | 3 |
| Details | binding site for residue GOL E 303 |
| Chain | Residue |
| E | ASP156 |
| E | ASP158 |
| E | LYS201 |
| site_id | AF1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL E 304 |
| Chain | Residue |
| E | GLN61 |
| E | PRO86 |
| E | PHE89 |
| E | ASN91 |
| E | ILE94 |
| E | LEU138 |
| E | TYR141 |
| site_id | AF2 |
| Number of Residues | 2 |
| Details | binding site for residue GOL E 305 |
| Chain | Residue |
| E | ASN91 |
| E | TYR141 |
| site_id | AF3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL E 306 |
| Chain | Residue |
| A | SER70 |
| E | HIS85 |
| E | TYR141 |
| site_id | AF4 |
| Number of Residues | 8 |
| Details | binding site for residue P6D E 307 |
| Chain | Residue |
| D | ILE171 |
| D | SER172 |
| D | GLU173 |
| E | TYR65 |
| E | ALA76 |
| E | ASP84 |
| E | PHE114 |
| E | ARG174 |
| site_id | AF5 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 F 301 |
| Chain | Residue |
| F | ALA30 |
| F | SER31 |
| F | GLY32 |
| F | LYS33 |
| F | SER34 |
| F | ARG169 |
| site_id | AF6 |
| Number of Residues | 2 |
| Details | binding site for residue GOL F 302 |
| Chain | Residue |
| F | LYS96 |
| F | GLU100 |
| site_id | AF7 |
| Number of Residues | 2 |
| Details | binding site for residue GOL F 303 |
| Chain | Residue |
| D | ARG210 |
| F | TYR203 |
| site_id | AF8 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 G 301 |
| Chain | Residue |
| G | GLY28 |
| G | ALA30 |
| G | SER31 |
| G | GLY32 |
| G | LYS33 |
| G | SER34 |
| G | ARG169 |
| site_id | AF9 |
| Number of Residues | 2 |
| Details | binding site for residue GOL G 302 |
| Chain | Residue |
| G | SER35 |
| G | ARG169 |
| site_id | AG1 |
| Number of Residues | 8 |
| Details | binding site for residue PO4 H 301 |
| Chain | Residue |
| H | GLY28 |
| H | ALA30 |
| H | SER31 |
| H | GLY32 |
| H | LYS33 |
| H | SER34 |
| H | ARG169 |
| H | HOH409 |
| site_id | AG2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL H 302 |
| Chain | Residue |
| H | ASP156 |
| H | ASP158 |
| H | PRO209 |
| H | ARG210 |
| site_id | AG3 |
| Number of Residues | 2 |
| Details | binding site for residue GOL H 303 |
| Chain | Residue |
| H | SER142 |
| H | GLU144 |
| site_id | AG4 |
| Number of Residues | 5 |
| Details | binding site for residue P6D H 304 |
| Chain | Residue |
| H | ASP62 |
| H | ASP84 |
| H | ILE137 |
| H | ARG174 |
| H | GLN184 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 64 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15130468, ECO:0000269|PubMed:15735337 |
| Chain | Residue | Details |
| A | GLY27 | |
| B | ASP84 | |
| B | TYR112 | |
| B | HIS117 | |
| B | ARG166 | |
| B | ARG176 | |
| B | GLN184 | |
| B | ASP213 | |
| C | GLY27 | |
| C | ASP84 | |
| C | TYR112 | |
| A | ASP84 | |
| C | HIS117 | |
| C | ARG166 | |
| C | ARG176 | |
| C | GLN184 | |
| C | ASP213 | |
| D | GLY27 | |
| D | ASP84 | |
| D | TYR112 | |
| D | HIS117 | |
| D | ARG166 | |
| A | TYR112 | |
| D | ARG176 | |
| D | GLN184 | |
| D | ASP213 | |
| E | GLY27 | |
| E | ASP84 | |
| E | TYR112 | |
| E | HIS117 | |
| E | ARG166 | |
| E | ARG176 | |
| E | GLN184 | |
| A | HIS117 | |
| E | ASP213 | |
| F | GLY27 | |
| F | ASP84 | |
| F | TYR112 | |
| F | HIS117 | |
| F | ARG166 | |
| F | ARG176 | |
| F | GLN184 | |
| F | ASP213 | |
| G | GLY27 | |
| A | ARG166 | |
| G | ASP84 | |
| G | TYR112 | |
| G | HIS117 | |
| G | ARG166 | |
| G | ARG176 | |
| G | GLN184 | |
| G | ASP213 | |
| H | GLY27 | |
| H | ASP84 | |
| H | TYR112 | |
| A | ARG176 | |
| H | HIS117 | |
| H | ARG166 | |
| H | ARG176 | |
| H | GLN184 | |
| H | ASP213 | |
| A | GLN184 | |
| A | ASP213 | |
| B | GLY27 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330 |
| Chain | Residue | Details |
| A | ALA2 | |
| B | ALA2 | |
| C | ALA2 | |
| D | ALA2 | |
| E | ALA2 | |
| F | ALA2 | |
| G | ALA2 | |
| H | ALA2 |
