6PWC
A complex structure of arrestin-2 bound to neurotensin receptor 1
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000139 | cellular_component | Golgi membrane |
A | 0000785 | cellular_component | chromatin |
A | 0001664 | molecular_function | G protein-coupled receptor binding |
A | 0001934 | biological_process | positive regulation of protein phosphorylation |
A | 0002029 | biological_process | desensitization of G protein-coupled receptor signaling pathway |
A | 0002031 | biological_process | G protein-coupled receptor internalization |
A | 0002092 | biological_process | positive regulation of receptor internalization |
A | 0003713 | molecular_function | transcription coactivator activity |
A | 0004402 | molecular_function | histone acetyltransferase activity |
A | 0004857 | molecular_function | enzyme inhibitor activity |
A | 0005096 | molecular_function | GTPase activator activity |
A | 0005159 | molecular_function | insulin-like growth factor receptor binding |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005765 | cellular_component | lysosomal membrane |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0005905 | cellular_component | clathrin-coated pit |
A | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
A | 0007165 | biological_process | signal transduction |
A | 0007600 | biological_process | sensory perception |
A | 0009968 | biological_process | negative regulation of signal transduction |
A | 0010613 | biological_process | positive regulation of cardiac muscle hypertrophy |
A | 0015031 | biological_process | protein transport |
A | 0016020 | cellular_component | membrane |
A | 0016567 | biological_process | protein ubiquitination |
A | 0016604 | cellular_component | nuclear body |
A | 0019899 | molecular_function | enzyme binding |
A | 0030659 | cellular_component | cytoplasmic vesicle membrane |
A | 0030666 | cellular_component | endocytic vesicle membrane |
A | 0031143 | cellular_component | pseudopodium |
A | 0031397 | biological_process | negative regulation of protein ubiquitination |
A | 0031410 | cellular_component | cytoplasmic vesicle |
A | 0031625 | molecular_function | ubiquitin protein ligase binding |
A | 0031701 | molecular_function | angiotensin receptor binding |
A | 0032088 | biological_process | negative regulation of NF-kappaB transcription factor activity |
A | 0032715 | biological_process | negative regulation of interleukin-6 production |
A | 0032717 | biological_process | negative regulation of interleukin-8 production |
A | 0035025 | biological_process | positive regulation of Rho protein signal transduction |
A | 0042995 | cellular_component | cell projection |
A | 0043149 | biological_process | stress fiber assembly |
A | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
A | 0045746 | biological_process | negative regulation of Notch signaling pathway |
A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
A | 0060090 | molecular_function | molecular adaptor activity |
A | 0070374 | biological_process | positive regulation of ERK1 and ERK2 cascade |
A | 1902533 | biological_process | positive regulation of intracellular signal transduction |
A | 1990763 | molecular_function | arrestin family protein binding |
R | 0004930 | molecular_function | G protein-coupled receptor activity |
R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
R | 0016020 | cellular_component | membrane |
R | 0016492 | molecular_function | G protein-coupled neurotensin receptor activity |
Functional Information from PROSITE/UniProt
site_id | PS00237 |
Number of Residues | 17 |
Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ATAlNVASLSVERYLaI |
Chain | Residue | Details |
R | ALA154-ILE170 |
site_id | PS00290 |
Number of Residues | 7 |
Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
Chain | Residue | Details |
H | TYR204-HIS210 | |
L | TYR193-HIS199 |
site_id | PS00295 |
Number of Residues | 19 |
Details | ARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL |
Chain | Residue | Details |
A | PHE61-LEU79 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 20 |
Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"UniProtKB","id":"P20789","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 32 |
Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"P20789","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 19 |
Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"UniProtKB","id":"P20789","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 64 |
Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"P20789","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI5 |
Number of Residues | 21 |
Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"UniProtKB","id":"P20789","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI6 |
Number of Residues | 20 |
Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"UniProtKB","id":"P20789","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI7 |
Number of Residues | 24 |
Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"UniProtKB","id":"P20789","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI8 |
Number of Residues | 21 |
Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"UniProtKB","id":"P20789","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI9 |
Number of Residues | 20 |
Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"UniProtKB","id":"P20789","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI10 |
Number of Residues | 23 |
Details | Region: {"description":"Neurotensin binding","evidences":[{"evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI11 |
Number of Residues | 2 |
Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"21725197","evidenceCode":"ECO:0000305"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI12 |
Number of Residues | 41 |
Details | Region: {"description":"Interaction with CHRM2","evidences":[{"evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI13 |
Number of Residues | 4 |
Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI14 |
Number of Residues | 1 |
Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8BWG8","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |