Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 701 |
| Chain | Residue |
| A | GLU548 |
| A | HOH1188 |
| B | GLU54 |
| B | HOH889 |
| B | HOH1101 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 702 |
| Chain | Residue |
| A | HOH845 |
| A | HOH895 |
| A | ASN106 |
| A | ASN117 |
| A | HIS122 |
| A | GLU124 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 703 |
| Chain | Residue |
| A | PHE127 |
| A | LYS130 |
| A | GLU148 |
| A | HOH897 |
| A | HOH1116 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 704 |
| Chain | Residue |
| A | ASP341 |
| A | ASP366 |
| A | ASN367 |
| A | HOH832 |
| A | HOH900 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 705 |
| Chain | Residue |
| A | ALA307 |
| A | SER308 |
| A | HOH854 |
| B | TYR194 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 706 |
| Chain | Residue |
| A | SER347 |
| A | ASP348 |
| A | TYR350 |
| A | HOH953 |
| B | ILE377 |
| B | ARG512 |
| B | EDO711 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 707 |
| Chain | Residue |
| A | GLU191 |
| A | TYR193 |
| A | PRO197 |
| A | PRO222 |
| A | LYS223 |
| A | HOH839 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 708 |
| Chain | Residue |
| A | TRP378 |
| A | ASN408 |
| A | ASP413 |
| A | ASN414 |
| A | ASN443 |
| A | HOH915 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 709 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 710 |
| Chain | Residue |
| A | ARG376 |
| A | GLY511 |
| A | ARG512 |
| A | HOH861 |
| B | SER355 |
| B | ALA356 |
| B | HOH1036 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 701 |
| Chain | Residue |
| B | ASN106 |
| B | ASN117 |
| B | HIS122 |
| B | GLU124 |
| B | HOH815 |
| B | HOH963 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue CA B 702 |
| Chain | Residue |
| B | ASP366 |
| B | HOH848 |
| B | HOH887 |
| B | HOH1014 |
| B | HOH1074 |
| B | HOH1184 |
| B | HOH1212 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 703 |
| Chain | Residue |
| B | PHE127 |
| B | LYS130 |
| B | GLU148 |
| B | HOH907 |
| B | HOH935 |
| B | HOH1164 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 704 |
| Chain | Residue |
| B | GLU40 |
| B | HOH824 |
| B | HOH1016 |
| B | HOH1166 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 705 |
| Chain | Residue |
| B | HIS162 |
| B | ASN165 |
| B | GLY486 |
| B | THR487 |
| B | HOH1084 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue CA B 706 |
| Chain | Residue |
| A | GLU54 |
| B | GLU545 |
| B | GLU548 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 707 |
| Chain | Residue |
| B | ASP348 |
| B | HOH1036 |
| site_id | AD9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 708 |
| Chain | Residue |
| B | PHE38 |
| B | LYS174 |
| site_id | AE1 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 709 |
| Chain | Residue |
| B | ASN408 |
| B | ASP413 |
| B | ASN414 |
| B | ASN443 |
| B | EDO711 |
| B | HOH806 |
| B | HOH983 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 710 |
| Chain | Residue |
| B | HOH898 |
| B | GLU191 |
| B | TYR193 |
| B | PRO197 |
| B | PRO222 |
| B | LYS223 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 711 |
| Chain | Residue |
| A | EDO706 |
| B | TRP378 |
| B | ASN414 |
| B | ARG512 |
| B | EDO709 |
| B | HOH806 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue CA C 701 |
| Chain | Residue |
| C | ASN464 |
| C | ILE465 |
| C | ASP467 |
| C | HOH999 |
| site_id | AE5 |
| Number of Residues | 7 |
| Details | binding site for residue CA C 702 |
| Chain | Residue |
| C | ASP366 |
| C | HOH804 |
| C | HOH988 |
| C | HOH1024 |
| C | HOH1134 |
| C | HOH1167 |
| C | HOH1185 |
| site_id | AE6 |
| Number of Residues | 7 |
| Details | binding site for residue CA C 703 |
| Chain | Residue |
| C | ASN106 |
| C | ASP113 |
| C | ASN117 |
| C | HIS122 |
| C | GLU124 |
| C | HOH810 |
| C | HOH874 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 704 |
| Chain | Residue |
| C | PHE127 |
| C | LYS130 |
| C | GLU148 |
| C | HOH871 |
| C | HOH1002 |
| C | HOH1169 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue CA C 705 |
| Chain | Residue |
| C | PRO197 |
| C | GLN446 |
| C | HOH949 |
| C | HOH1124 |
| site_id | AE9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 706 |
| Chain | Residue |
| C | SER308 |
| D | ASN414 |
| site_id | AF1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 707 |
| Chain | Residue |
| C | ASN200 |
| C | PHE220 |
| C | ASP225 |
| C | LYS240 |
| C | GLU243 |
| C | ILE244 |
| site_id | AF2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 708 |
| Chain | Residue |
| C | GLY351 |
| C | ASN352 |
| C | GLY353 |
| C | SER354 |
| C | SER355 |
| site_id | AF3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 709 |
| Chain | Residue |
| C | SER230 |
| C | LYS231 |
| C | TRP232 |
| C | ARG233 |
| C | ASN268 |
| D | HOH824 |
| site_id | AF4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 710 |
| Chain | Residue |
| C | GLU191 |
| C | TYR193 |
| C | PRO197 |
| C | PRO222 |
| C | LYS223 |
| C | HOH872 |
| site_id | AF5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 711 |
| Chain | Residue |
| C | ILE377 |
| C | ARG512 |
| C | HOH980 |
| D | SER347 |
| D | ASP348 |
| site_id | AF6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO C 712 |
| Chain | Residue |
| C | TRP378 |
| C | ASN408 |
| C | ASP413 |
| C | ASN414 |
| C | ASN443 |
| C | HOH888 |
| C | HOH975 |
| site_id | AF7 |
| Number of Residues | 7 |
| Details | binding site for residue CA D 701 |
| Chain | Residue |
| D | ASP366 |
| D | HOH861 |
| D | HOH958 |
| D | HOH1026 |
| D | HOH1124 |
| D | HOH1164 |
| D | HOH1166 |
| site_id | AF8 |
| Number of Residues | 6 |
| Details | binding site for residue CA D 702 |
| Chain | Residue |
| D | ASN106 |
| D | ASN117 |
| D | HIS122 |
| D | GLU124 |
| D | HOH823 |
| D | HOH865 |
| site_id | AF9 |
| Number of Residues | 5 |
| Details | binding site for residue CA D 703 |
| Chain | Residue |
| C | GLU54 |
| C | HOH898 |
| D | GLU545 |
| D | GLU548 |
| D | HOH1134 |
| site_id | AG1 |
| Number of Residues | 5 |
| Details | binding site for residue CA D 704 |
| Chain | Residue |
| D | PHE127 |
| D | LYS130 |
| D | GLU148 |
| D | HOH879 |
| D | HOH1123 |
| site_id | AG2 |
| Number of Residues | 5 |
| Details | binding site for residue CA D 705 |
| Chain | Residue |
| D | GLN46 |
| D | GLU183 |
| D | ASN464 |
| D | HOH945 |
| D | HOH948 |
| site_id | AG3 |
| Number of Residues | 9 |
| Details | binding site for residue EDO D 706 |
| Chain | Residue |
| C | SER347 |
| C | ASP348 |
| C | TYR350 |
| C | HOH805 |
| D | ILE377 |
| D | TRP378 |
| D | ARG512 |
| D | HOH902 |
| D | HOH961 |
| site_id | AG4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO D 707 |
| Chain | Residue |
| B | GLU276 |
| D | SER230 |
| D | LYS231 |
| D | TRP232 |
| D | ARG233 |
| D | ASN267 |
| D | ASN268 |
| site_id | AG5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 708 |
| Chain | Residue |
| D | GLU191 |
| D | TYR193 |
| D | PRO197 |
| D | PRO222 |
| D | LYS223 |
| D | HOH857 |
| site_id | AG6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 709 |
| Chain | Residue |
| C | GLU169 |
| C | GLY170 |
| D | TYR559 |
| D | HOH870 |
