6PUL

Structure of human MAIT A-F7 TCR in complex with human MR1 3'D-5-OP-RU

Functional Information from GO Data

Chain	GOid	namespace	contents
F	0000139	cellular_component	Golgi membrane
F	0002376	biological_process	immune system process
F	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
F	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
F	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
F	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
F	0002715	biological_process	regulation of natural killer cell mediated immunity
F	0002726	biological_process	positive regulation of T cell cytokine production
F	0005198	molecular_function	structural molecule activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005765	cellular_component	lysosomal membrane
F	0005783	cellular_component	endoplasmic reticulum
F	0005788	cellular_component	endoplasmic reticulum lumen
F	0005794	cellular_component	Golgi apparatus
F	0005886	cellular_component	plasma membrane
F	0005925	cellular_component	focal adhesion
F	0006879	biological_process	intracellular iron ion homeostasis
F	0006955	biological_process	immune response
F	0007608	biological_process	sensory perception of smell
F	0007611	biological_process	learning or memory
F	0009897	cellular_component	external side of plasma membrane
F	0009986	cellular_component	cell surface
F	0010038	biological_process	response to metal ion
F	0012507	cellular_component	ER to Golgi transport vesicle membrane
F	0016020	cellular_component	membrane
F	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
F	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
F	0023026	molecular_function	MHC class II protein complex binding
F	0030670	cellular_component	phagocytic vesicle membrane
F	0031901	cellular_component	early endosome membrane
F	0031902	cellular_component	late endosome membrane
F	0031905	cellular_component	early endosome lumen
F	0032398	cellular_component	MHC class Ib protein complex
F	0033572	biological_process	transferrin transport
F	0034756	biological_process	regulation of iron ion transport
F	0034757	biological_process	negative regulation of iron ion transport
F	0035580	cellular_component	specific granule lumen
F	0042605	molecular_function	peptide antigen binding
F	0042612	cellular_component	MHC class I protein complex
F	0042613	cellular_component	MHC class II protein complex
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0042824	cellular_component	MHC class I peptide loading complex
F	0048260	biological_process	positive regulation of receptor-mediated endocytosis
F	0048261	biological_process	negative regulation of receptor-mediated endocytosis
F	0050680	biological_process	negative regulation of epithelial cell proliferation
F	0050768	biological_process	negative regulation of neurogenesis
F	0050778	biological_process	positive regulation of immune response
F	0050870	biological_process	positive regulation of T cell activation
F	0051289	biological_process	protein homotetramerization
F	0055038	cellular_component	recycling endosome membrane
F	0070062	cellular_component	extracellular exosome
F	0071281	biological_process	cellular response to iron ion
F	0071316	biological_process	cellular response to nicotine
F	1904724	cellular_component	tertiary granule lumen
F	1990000	biological_process	amyloid fibril formation
F	1990712	cellular_component	HFE-transferrin receptor complex
F	2000774	biological_process	positive regulation of cellular senescence
F	2000978	biological_process	negative regulation of forebrain neuron differentiation
H	0000139	cellular_component	Golgi membrane
H	0002376	biological_process	immune system process
H	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
H	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
H	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
H	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
H	0002715	biological_process	regulation of natural killer cell mediated immunity
H	0002726	biological_process	positive regulation of T cell cytokine production
H	0005198	molecular_function	structural molecule activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005765	cellular_component	lysosomal membrane
H	0005783	cellular_component	endoplasmic reticulum
H	0005788	cellular_component	endoplasmic reticulum lumen
H	0005794	cellular_component	Golgi apparatus
H	0005886	cellular_component	plasma membrane
H	0005925	cellular_component	focal adhesion
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006955	biological_process	immune response
H	0007608	biological_process	sensory perception of smell
H	0007611	biological_process	learning or memory
H	0009897	cellular_component	external side of plasma membrane
H	0009986	cellular_component	cell surface
H	0010038	biological_process	response to metal ion
H	0012507	cellular_component	ER to Golgi transport vesicle membrane
H	0016020	cellular_component	membrane
H	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
H	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
H	0023026	molecular_function	MHC class II protein complex binding
H	0030670	cellular_component	phagocytic vesicle membrane
H	0031901	cellular_component	early endosome membrane
H	0031902	cellular_component	late endosome membrane
H	0031905	cellular_component	early endosome lumen
H	0032398	cellular_component	MHC class Ib protein complex
H	0033572	biological_process	transferrin transport
H	0034756	biological_process	regulation of iron ion transport
H	0034757	biological_process	negative regulation of iron ion transport
H	0035580	cellular_component	specific granule lumen
H	0042605	molecular_function	peptide antigen binding
H	0042612	cellular_component	MHC class I protein complex
H	0042613	cellular_component	MHC class II protein complex
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0042824	cellular_component	MHC class I peptide loading complex
H	0048260	biological_process	positive regulation of receptor-mediated endocytosis
H	0048261	biological_process	negative regulation of receptor-mediated endocytosis
H	0050680	biological_process	negative regulation of epithelial cell proliferation
H	0050768	biological_process	negative regulation of neurogenesis
H	0050778	biological_process	positive regulation of immune response
H	0050870	biological_process	positive regulation of T cell activation
H	0051289	biological_process	protein homotetramerization
H	0055038	cellular_component	recycling endosome membrane
H	0070062	cellular_component	extracellular exosome
H	0071281	biological_process	cellular response to iron ion
H	0071316	biological_process	cellular response to nicotine
H	1904724	cellular_component	tertiary granule lumen
H	1990000	biological_process	amyloid fibril formation
H	1990712	cellular_component	HFE-transferrin receptor complex
H	2000774	biological_process	positive regulation of cellular senescence
H	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue GOL A 301

Chain	Residue
A	TYR84
A	TYR114
A	GLN117
A	ASP118
A	PHE119
A	ASP133
A	HOH494

---

site_id	AC2
Number of Residues	6
Details	binding site for residue GOL A 302

Chain	Residue
A	HOH493
G	THR54
G	THR55
G	ASP56
A	GLN64
A	ARG67

---

site_id	AC3
Number of Residues	16
Details	binding site for residue Q81 A 303

Chain	Residue
A	TYR7
A	ARG9
A	SER24
A	LYS43
A	TYR62
A	LEU66
A	TRP69
A	ARG94
A	ILE96
A	TYR152
A	GLN153
A	TRP156
A	HOH484
A	HOH497
A	HOH538
B	TYR95

---

site_id	AC4
Number of Residues	4
Details	binding site for residue GOL B 401

Chain	Residue
B	GLU193
B	THR195
B	HOH504
B	HOH518

---

site_id	AC5
Number of Residues	17
Details	binding site for residue Q81 C 301

Chain	Residue
C	TYR7
C	ARG9
C	SER24
C	LYS43
C	HIS58
C	TYR62
C	LEU66
C	TRP69
C	ARG94
C	ILE96
C	TYR152
C	GLN153
C	TRP156
C	HOH439
C	HOH493
C	HOH522
D	TYR95

---

site_id	AC6
Number of Residues	4
Details	binding site for residue GOL D 301

Chain	Residue
D	GLN19
D	TYR70
D	HOH425
D	HOH437

---

site_id	AC7
Number of Residues	5
Details	binding site for residue ACT E 301

Chain	Residue
D	GLY40
D	HOH408
E	ARG111
E	HOH410
E	HOH464

---

site_id	AC8
Number of Residues	6
Details	binding site for residue NA E 302

Chain	Residue
E	TYR47
E	PRO61
E	TYR64
E	HOH423
E	HOH427
E	HOH482

---

site_id	AC9
Number of Residues	8
Details	binding site for residue GOL F 101

Chain	Residue
F	GLN8
F	VAL9
F	VAL93
F	LYS94
F	TRP95
F	ASP96
F	HOH218
F	HOH222

---

site_id	AD1
Number of Residues	5
Details	binding site for residue GOL F 102

Chain	Residue
F	PRO5
F	LYS6
F	ILE7
F	LYS91
F	VAL93

---

site_id	AD2
Number of Residues	4
Details	binding site for residue NA F 103

Chain	Residue
F	THR71
F	THR73
F	ASP76
F	TYR78

---

site_id	AD3
Number of Residues	6
Details	binding site for residue NA F 104

Chain	Residue
F	ASN83
F	HIS84
F	LEU87
F	HOH278
F	HOH299
F	HOH304

---

site_id	AD4
Number of Residues	6
Details	binding site for residue GOL G 301

Chain	Residue
G	ARG36
G	ARG44
G	SER84
G	HOH420
G	HOH463
G	HOH578

---

site_id	AD5
Number of Residues	6
Details	binding site for residue NA G 302

Chain	Residue
G	HOH524
G	TYR47
G	PRO61
G	TYR64
G	HOH498
G	HOH510

---

site_id	AD6
Number of Residues	6
Details	binding site for residue NA H 501

Chain	Residue
H	ASN83
H	HIS84
H	LEU87
H	HOH656
H	HOH657
H	HOH660

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH

Chain	Residue	Details
F	TYR78-HIS84
A	TYR254-HIS260

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	356
Details	Region: {"description":"Antigen-binding cleft","evidences":[{"source":"PubMed","id":"23846752","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24695216","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26795251","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	172
Details	Region: {"description":"Alpha-1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	182
Details	Region: {"description":"Alpha-2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"39701104","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8BP6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23846752","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24101382","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LCW","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"4L4V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"39589872","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9CGR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23846752","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4L4V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12794138","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	176
Details	Domain: {"description":"Ig-like C1-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	12
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---