Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6PTE

Crystal Structure of ILNAMITKI peptide bound to HLA-A2

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000139	cellular_component	Golgi membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002376	biological_process	immune system process
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0010038	biological_process	response to metal ion
B	0010977	biological_process	negative regulation of neuron projection development
B	0012507	cellular_component	ER to Golgi transport vesicle membrane
B	0016020	cellular_component	membrane
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0031905	cellular_component	early endosome lumen
B	0033077	biological_process	T cell differentiation in thymus
B	0033572	biological_process	transferrin transport
B	0034756	biological_process	regulation of iron ion transport
B	0034757	biological_process	negative regulation of iron ion transport
B	0035580	cellular_component	specific granule lumen
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0048261	biological_process	negative regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0055038	cellular_component	recycling endosome membrane
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0070062	cellular_component	extracellular exosome
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1904724	cellular_component	tertiary granule lumen
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
F	0000139	cellular_component	Golgi membrane
F	0001913	biological_process	T cell mediated cytotoxicity
F	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
F	0002237	biological_process	response to molecule of bacterial origin
F	0002376	biological_process	immune system process
F	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
F	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
F	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
F	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
F	0002726	biological_process	positive regulation of T cell cytokine production
F	0005198	molecular_function	structural molecule activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005765	cellular_component	lysosomal membrane
F	0005783	cellular_component	endoplasmic reticulum
F	0005788	cellular_component	endoplasmic reticulum lumen
F	0005794	cellular_component	Golgi apparatus
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005925	cellular_component	focal adhesion
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0006955	biological_process	immune response
F	0007608	biological_process	sensory perception of smell
F	0007611	biological_process	learning or memory
F	0009897	cellular_component	external side of plasma membrane
F	0009986	cellular_component	cell surface
F	0010038	biological_process	response to metal ion
F	0010977	biological_process	negative regulation of neuron projection development
F	0012507	cellular_component	ER to Golgi transport vesicle membrane
F	0016020	cellular_component	membrane
F	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
F	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
F	0023026	molecular_function	MHC class II protein complex binding
F	0030670	cellular_component	phagocytic vesicle membrane
F	0031901	cellular_component	early endosome membrane
F	0031902	cellular_component	late endosome membrane
F	0031905	cellular_component	early endosome lumen
F	0033077	biological_process	T cell differentiation in thymus
F	0033572	biological_process	transferrin transport
F	0034756	biological_process	regulation of iron ion transport
F	0034757	biological_process	negative regulation of iron ion transport
F	0035580	cellular_component	specific granule lumen
F	0042026	biological_process	protein refolding
F	0042605	molecular_function	peptide antigen binding
F	0042612	cellular_component	MHC class I protein complex
F	0042613	cellular_component	MHC class II protein complex
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0042824	cellular_component	MHC class I peptide loading complex
F	0045646	biological_process	regulation of erythrocyte differentiation
F	0048260	biological_process	positive regulation of receptor-mediated endocytosis
F	0048261	biological_process	negative regulation of receptor-mediated endocytosis
F	0050680	biological_process	negative regulation of epithelial cell proliferation
F	0050768	biological_process	negative regulation of neurogenesis
F	0050778	biological_process	positive regulation of immune response
F	0050870	biological_process	positive regulation of T cell activation
F	0051289	biological_process	protein homotetramerization
F	0055038	cellular_component	recycling endosome membrane
F	0060586	biological_process	multicellular organismal-level iron ion homeostasis
F	0070062	cellular_component	extracellular exosome
F	0071281	biological_process	cellular response to iron ion
F	0071283	biological_process	cellular response to iron(III) ion
F	0071316	biological_process	cellular response to nicotine
F	1904724	cellular_component	tertiary granule lumen
F	1990000	biological_process	amyloid fibril formation
F	1990712	cellular_component	HFE-transferrin receptor complex
F	2000774	biological_process	positive regulation of cellular senescence
F	2000978	biological_process	negative regulation of forebrain neuron differentiation
I	0000139	cellular_component	Golgi membrane
I	0001913	biological_process	T cell mediated cytotoxicity
I	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
I	0002237	biological_process	response to molecule of bacterial origin
I	0002376	biological_process	immune system process
I	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
I	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
I	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
I	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
I	0002726	biological_process	positive regulation of T cell cytokine production
I	0005198	molecular_function	structural molecule activity
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005765	cellular_component	lysosomal membrane
I	0005783	cellular_component	endoplasmic reticulum
I	0005788	cellular_component	endoplasmic reticulum lumen
I	0005794	cellular_component	Golgi apparatus
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0005925	cellular_component	focal adhesion
I	0006826	biological_process	iron ion transport
I	0006879	biological_process	intracellular iron ion homeostasis
I	0006955	biological_process	immune response
I	0007608	biological_process	sensory perception of smell
I	0007611	biological_process	learning or memory
I	0009897	cellular_component	external side of plasma membrane
I	0009986	cellular_component	cell surface
I	0010038	biological_process	response to metal ion
I	0010977	biological_process	negative regulation of neuron projection development
I	0012507	cellular_component	ER to Golgi transport vesicle membrane
I	0016020	cellular_component	membrane
I	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
I	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
I	0023026	molecular_function	MHC class II protein complex binding
I	0030670	cellular_component	phagocytic vesicle membrane
I	0031901	cellular_component	early endosome membrane
I	0031902	cellular_component	late endosome membrane
I	0031905	cellular_component	early endosome lumen
I	0033077	biological_process	T cell differentiation in thymus
I	0033572	biological_process	transferrin transport
I	0034756	biological_process	regulation of iron ion transport
I	0034757	biological_process	negative regulation of iron ion transport
I	0035580	cellular_component	specific granule lumen
I	0042026	biological_process	protein refolding
I	0042605	molecular_function	peptide antigen binding
I	0042612	cellular_component	MHC class I protein complex
I	0042613	cellular_component	MHC class II protein complex
I	0042802	molecular_function	identical protein binding
I	0042803	molecular_function	protein homodimerization activity
I	0042824	cellular_component	MHC class I peptide loading complex
I	0045646	biological_process	regulation of erythrocyte differentiation
I	0048260	biological_process	positive regulation of receptor-mediated endocytosis
I	0048261	biological_process	negative regulation of receptor-mediated endocytosis
I	0050680	biological_process	negative regulation of epithelial cell proliferation
I	0050768	biological_process	negative regulation of neurogenesis
I	0050778	biological_process	positive regulation of immune response
I	0050870	biological_process	positive regulation of T cell activation
I	0051289	biological_process	protein homotetramerization
I	0055038	cellular_component	recycling endosome membrane
I	0060586	biological_process	multicellular organismal-level iron ion homeostasis
I	0070062	cellular_component	extracellular exosome
I	0071281	biological_process	cellular response to iron ion
I	0071283	biological_process	cellular response to iron(III) ion
I	0071316	biological_process	cellular response to nicotine
I	1904724	cellular_component	tertiary granule lumen
I	1990000	biological_process	amyloid fibril formation
I	1990712	cellular_component	HFE-transferrin receptor complex
I	2000774	biological_process	positive regulation of cellular senescence
I	2000978	biological_process	negative regulation of forebrain neuron differentiation
L	0000139	cellular_component	Golgi membrane
L	0001913	biological_process	T cell mediated cytotoxicity
L	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
L	0002237	biological_process	response to molecule of bacterial origin
L	0002376	biological_process	immune system process
L	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
L	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
L	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
L	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
L	0002726	biological_process	positive regulation of T cell cytokine production
L	0005198	molecular_function	structural molecule activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005765	cellular_component	lysosomal membrane
L	0005783	cellular_component	endoplasmic reticulum
L	0005788	cellular_component	endoplasmic reticulum lumen
L	0005794	cellular_component	Golgi apparatus
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0005925	cellular_component	focal adhesion
L	0006826	biological_process	iron ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0006955	biological_process	immune response
L	0007608	biological_process	sensory perception of smell
L	0007611	biological_process	learning or memory
L	0009897	cellular_component	external side of plasma membrane
L	0009986	cellular_component	cell surface
L	0010038	biological_process	response to metal ion
L	0010977	biological_process	negative regulation of neuron projection development
L	0012507	cellular_component	ER to Golgi transport vesicle membrane
L	0016020	cellular_component	membrane
L	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
L	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
L	0023026	molecular_function	MHC class II protein complex binding
L	0030670	cellular_component	phagocytic vesicle membrane
L	0031901	cellular_component	early endosome membrane
L	0031902	cellular_component	late endosome membrane
L	0031905	cellular_component	early endosome lumen
L	0033077	biological_process	T cell differentiation in thymus
L	0033572	biological_process	transferrin transport
L	0034756	biological_process	regulation of iron ion transport
L	0034757	biological_process	negative regulation of iron ion transport
L	0035580	cellular_component	specific granule lumen
L	0042026	biological_process	protein refolding
L	0042605	molecular_function	peptide antigen binding
L	0042612	cellular_component	MHC class I protein complex
L	0042613	cellular_component	MHC class II protein complex
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0042824	cellular_component	MHC class I peptide loading complex
L	0045646	biological_process	regulation of erythrocyte differentiation
L	0048260	biological_process	positive regulation of receptor-mediated endocytosis
L	0048261	biological_process	negative regulation of receptor-mediated endocytosis
L	0050680	biological_process	negative regulation of epithelial cell proliferation
L	0050768	biological_process	negative regulation of neurogenesis
L	0050778	biological_process	positive regulation of immune response
L	0050870	biological_process	positive regulation of T cell activation
L	0051289	biological_process	protein homotetramerization
L	0055038	cellular_component	recycling endosome membrane
L	0060586	biological_process	multicellular organismal-level iron ion homeostasis
L	0070062	cellular_component	extracellular exosome
L	0071281	biological_process	cellular response to iron ion
L	0071283	biological_process	cellular response to iron(III) ion
L	0071316	biological_process	cellular response to nicotine
L	1904724	cellular_component	tertiary granule lumen
L	1990000	biological_process	amyloid fibril formation
L	1990712	cellular_component	HFE-transferrin receptor complex
L	2000774	biological_process	positive regulation of cellular senescence
L	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue GOL A 401

Chain	Residue
A	TYR59
A	GLY62
A	GLU63
A	LYS66
A	HOH539
A	HOH618

site_id	AC2
Number of Residues	8
Details	binding site for residue GOL A 402

Chain	Residue
A	HIS192
A	ALA193
A	HOH503
A	HOH563
A	HOH580
A	TYR84
A	ASN86
A	HIS191

site_id	AC3
Number of Residues	6
Details	binding site for residue NA B 201

Chain	Residue
B	ASN84
B	HIS85
B	LEU88
B	HOH384
B	HOH386
B	HOH391

site_id	AC4
Number of Residues	9
Details	binding site for residue GOL C 301

Chain	Residue
A	ARG97
A	TRP147
A	VAL152
A	LEU156
A	HOH547
C	ASN3
C	MET5
C	ILE6
C	THR7

site_id	AC5
Number of Residues	9
Details	binding site for residue GOL E 401

Chain	Residue
D	ILE1
E	GLU58
E	TYR59
E	GLY62
E	GLU63
E	HOH534
E	HOH545
E	HOH592
E	HOH685

site_id	AC6
Number of Residues	8
Details	binding site for residue GOL E 402

Chain	Residue
E	TYR84
E	ASN86
E	HIS191
E	HIS192
E	ALA193
E	HOH524
E	HOH638
E	HOH662

site_id	AC7
Number of Residues	6
Details	binding site for residue NA F 201

Chain	Residue
F	ASN84
F	HIS85
F	LEU88
F	HOH388
F	HOH391
F	HOH396

site_id	AC8
Number of Residues	9
Details	binding site for residue GOL D 301

Chain	Residue
D	ASN3
D	MET5
D	ILE6
D	THR7
E	ARG97
E	HIS114
E	TRP147
E	VAL152
E	HOH607

site_id	AC9
Number of Residues	8
Details	binding site for residue GOL H 401

Chain	Residue
H	TYR59
H	GLY62
H	GLU63
H	LYS66
H	TRP167
H	HOH588
H	HOH615
H	HOH658

site_id	AD1
Number of Residues	8
Details	binding site for residue GOL H 402

Chain	Residue
H	TYR84
H	ASN86
H	HIS191
H	HIS192
H	ALA193
H	HOH508
H	HOH568
H	HOH665

site_id	AD2
Number of Residues	5
Details	binding site for residue NA I 201

Chain	Residue
I	ASN84
I	HIS85
I	LEU88
I	HOH381
I	HOH385

site_id	AD3
Number of Residues	10
Details	binding site for residue GOL G 301

Chain	Residue
G	ASN3
G	MET5
G	ILE6
G	THR7
H	ARG97
H	HIS114
H	TRP147
H	VAL152
H	LEU156
H	HOH558

site_id	AD4
Number of Residues	8
Details	binding site for residue GOL K 401

Chain	Residue
K	HOH538
K	TYR84
K	ASN86
K	HIS191
K	HIS192
K	ALA193
K	HOH503
K	HOH533

site_id	AD5
Number of Residues	6
Details	binding site for residue GOL K 402

Chain	Residue
K	TYR59
K	GLY62
K	GLU63
K	HOH508
K	HOH619
K	HOH689

site_id	AD6
Number of Residues	6
Details	binding site for residue NA L 201

Chain	Residue
L	ASN84
L	HIS85
L	LEU88
L	HOH384
L	HOH392
L	HOH395

site_id	AD7
Number of Residues	9
Details	binding site for residue GOL J 301

Chain	Residue
J	ASN3
J	MET5
J	ILE6
J	THR7
K	ARG97
K	HIS114
K	TRP147
K	VAL152
K	HOH597

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH

Chain	Residue	Details
B	TYR79-HIS85
A	TYR257-HIS263

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269\|PubMed:7554280

Chain	Residue	Details
B	GLN3
E	THR143
E	LYS146
E	TYR171
H	TYR7
H	THR73
H	TYR84
H	THR143
H	LYS146
H	TYR171
K	TYR7
F	GLN3
K	THR73
K	TYR84
K	THR143
K	LYS146
K	TYR171
I	GLN3
L	GLN3
A	LYS146
A	TYR171
E	TYR7
E	THR73
E	TYR84

site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269\|PubMed:7918443

Chain	Residue	Details
B	ILE2
F	ILE2
I	ILE2
L	ILE2
H	TYR116
H	TYR159
K	TYR116
K	TYR159

site_id	SWS_FT_FI3
Number of Residues	24
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269\|PubMed:7918443

Chain	Residue	Details
B	LYS20
F	LYS59
F	LYS92
F	LYS95
I	LYS20
I	LYS42
I	LYS49
I	LYS59
I	LYS92
I	LYS95
L	LYS20
B	LYS42
L	LYS42
L	LYS49
L	LYS59
L	LYS92
L	LYS95
B	LYS49
B	LYS59
B	LYS92
B	LYS95
F	LYS20
F	LYS42
F	LYS49

site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218

Chain	Residue	Details
A	ASN86
E	ASN86
H	ASN86
K	ASN86

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)