6PME
TRK-A IN COMPLEX WITH LIGAND
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| B | 0016020 | cellular_component | membrane |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0004713 | molecular_function | protein tyrosine kinase activity |
| C | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| C | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| C | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 801 |
| Chain | Residue |
| A | HIS504 |
| A | CYS579 |
| A | GLU581 |
| B | CYS501 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue OOY A 802 |
| Chain | Residue |
| A | MET592 |
| A | ARG593 |
| A | GLY595 |
| A | ASP596 |
| A | ARG654 |
| A | LEU657 |
| A | GLY667 |
| A | PHE669 |
| A | GLY670 |
| A | LEU516 |
| A | ALA542 |
| A | PHE589 |
| A | GLU590 |
| A | TYR591 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue SRT A 803 |
| Chain | Residue |
| A | HIS571 |
| A | SER632 |
| A | GLN633 |
| A | HIS778 |
| A | GLN782 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 801 |
| Chain | Residue |
| B | HIS504 |
| B | ILE505 |
| B | CYS579 |
| B | GLU581 |
| C | CYS501 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue OOY B 802 |
| Chain | Residue |
| B | ALA542 |
| B | VAL573 |
| B | PHE589 |
| B | GLU590 |
| B | TYR591 |
| B | MET592 |
| B | ARG593 |
| B | LEU657 |
| B | GLY667 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue SRT B 803 |
| Chain | Residue |
| B | HIS571 |
| B | ALA629 |
| B | SER632 |
| B | GLN633 |
| B | HIS778 |
| B | GLN782 |
| B | ALA785 |
| C | PRO619 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue ZN C 801 |
| Chain | Residue |
| A | CYS501 |
| C | HIS504 |
| C | ILE505 |
| C | CYS579 |
| C | GLU581 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | binding site for residue OOY C 802 |
| Chain | Residue |
| C | LEU516 |
| C | GLY517 |
| C | ALA542 |
| C | PHE589 |
| C | GLU590 |
| C | TYR591 |
| C | MET592 |
| C | ARG593 |
| C | GLY595 |
| C | LEU657 |
| C | GLY667 |
| C | PHE669 |
| C | GLY670 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 29 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGKVFlAechnllpeqdkml.....VAVK |
| Chain | Residue | Details |
| A | LEU516-LYS544 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLATRNCLV |
| Chain | Residue | Details |
| A | PHE646-VAL658 |
| site_id | PS00239 |
| Number of Residues | 9 |
| Details | RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DIYstdYYR |
| Chain | Residue | Details |
| A | ASP674-ARG682 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 45 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY522-ASP537 | |
| B | GLY522-ASP537 | |
| C | GLY522-ASP537 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 |
| Chain | Residue | Details |
| A | ARG748 | |
| B | ARG748 | |
| C | ARG748 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | GLY614 | |
| A | ALA642 | |
| B | GLY614 | |
| B | ALA642 | |
| C | GLY614 | |
| C | ALA642 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | SITE: Breakpoint for translocation to form TRK and TRK-T3 |
| Chain | Residue | Details |
| A | TYR496 | |
| B | TYR496 | |
| C | TYR496 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | SITE: Breakpoint for translocation to form TRK-T1 |
| Chain | Residue | Details |
| A | PRO584 | |
| B | PRO584 | |
| C | PRO584 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | SITE: Interaction with SHC1 |
| Chain | Residue | Details |
| A | HIS594 | |
| B | HIS594 | |
| C | HIS594 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:27676246, ECO:0000269|PubMed:8155326 |
| Chain | Residue | Details |
| A | HIS594 | |
| B | HIS594 | |
| C | HIS594 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:8155326 |
| Chain | Residue | Details |
| A | ILE774 | |
| B | ILE774 | |
| C | ILE774 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:8155326 |
| Chain | Residue | Details |
| A | HIS778 | |
| A | ALA779 | |
| B | HIS778 | |
| B | ALA779 | |
| C | HIS778 | |
| C | ALA779 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASP499 | |
| B | ASP499 | |
| C | ASP499 |
