6PLM

Legionella pneumophila SidJ/ Calmodulin 2 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000086	biological_process	G2/M transition of mitotic cell cycle
C	0000922	cellular_component	spindle pole
C	0002027	biological_process	regulation of heart rate
C	0005509	molecular_function	calcium ion binding
C	0005513	biological_process	detection of calcium ion
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005856	cellular_component	cytoskeleton
C	0005876	cellular_component	spindle microtubule
C	0005886	cellular_component	plasma membrane
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0008076	cellular_component	voltage-gated potassium channel complex
C	0008179	molecular_function	adenylate cyclase binding
C	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
C	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
C	0010856	molecular_function	adenylate cyclase activator activity
C	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C	0016020	cellular_component	membrane
C	0019855	molecular_function	calcium channel inhibitor activity
C	0019901	molecular_function	protein kinase binding
C	0021762	biological_process	substantia nigra development
C	0030017	cellular_component	sarcomere
C	0031432	molecular_function	titin binding
C	0031954	biological_process	positive regulation of protein autophosphorylation
C	0031982	cellular_component	vesicle
C	0032465	biological_process	regulation of cytokinesis
C	0032516	biological_process	positive regulation of phosphoprotein phosphatase activity
C	0032991	cellular_component	protein-containing complex
C	0034704	cellular_component	calcium channel complex
C	0035307	biological_process	positive regulation of protein dephosphorylation
C	0043209	cellular_component	myelin sheath
C	0043539	molecular_function	protein serine/threonine kinase activator activity
C	0044325	molecular_function	transmembrane transporter binding
C	0046872	molecular_function	metal ion binding
C	0048306	molecular_function	calcium-dependent protein binding
C	0050848	biological_process	regulation of calcium-mediated signaling
C	0051343	biological_process	positive regulation of cyclic-nucleotide phosphodiesterase activity
C	0051592	biological_process	response to calcium ion
C	0055117	biological_process	regulation of cardiac muscle contraction
C	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
C	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
C	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
C	0072542	molecular_function	protein phosphatase activator activity
C	0097225	cellular_component	sperm midpiece
C	1901020	biological_process	negative regulation of calcium ion transmembrane transporter activity
C	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
C	1902494	cellular_component	catalytic complex
C	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
D	0000086	biological_process	G2/M transition of mitotic cell cycle
D	0000922	cellular_component	spindle pole
D	0002027	biological_process	regulation of heart rate
D	0005509	molecular_function	calcium ion binding
D	0005513	biological_process	detection of calcium ion
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005819	cellular_component	spindle
D	0005856	cellular_component	cytoskeleton
D	0005876	cellular_component	spindle microtubule
D	0005886	cellular_component	plasma membrane
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0008076	cellular_component	voltage-gated potassium channel complex
D	0008179	molecular_function	adenylate cyclase binding
D	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
D	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
D	0010856	molecular_function	adenylate cyclase activator activity
D	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D	0016020	cellular_component	membrane
D	0019855	molecular_function	calcium channel inhibitor activity
D	0019901	molecular_function	protein kinase binding
D	0021762	biological_process	substantia nigra development
D	0030017	cellular_component	sarcomere
D	0031432	molecular_function	titin binding
D	0031954	biological_process	positive regulation of protein autophosphorylation
D	0031982	cellular_component	vesicle
D	0032465	biological_process	regulation of cytokinesis
D	0032516	biological_process	positive regulation of phosphoprotein phosphatase activity
D	0032991	cellular_component	protein-containing complex
D	0034704	cellular_component	calcium channel complex
D	0035307	biological_process	positive regulation of protein dephosphorylation
D	0043209	cellular_component	myelin sheath
D	0043539	molecular_function	protein serine/threonine kinase activator activity
D	0044325	molecular_function	transmembrane transporter binding
D	0046872	molecular_function	metal ion binding
D	0048306	molecular_function	calcium-dependent protein binding
D	0050848	biological_process	regulation of calcium-mediated signaling
D	0051343	biological_process	positive regulation of cyclic-nucleotide phosphodiesterase activity
D	0051592	biological_process	response to calcium ion
D	0055117	biological_process	regulation of cardiac muscle contraction
D	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
D	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
D	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
D	0072542	molecular_function	protein phosphatase activator activity
D	0097225	cellular_component	sperm midpiece
D	1901020	biological_process	negative regulation of calcium ion transmembrane transporter activity
D	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
D	1902494	cellular_component	catalytic complex
D	1905913	biological_process	negative regulation of calcium ion export across plasma membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue CA A 1001

Chain	Residue
A	ASP542
A	ASP545
A	POP1003

---

site_id	AC2
Number of Residues	3
Details	binding site for residue CA A 1002

Chain	Residue
A	ASN534
A	ASP542
A	POP1003

---

site_id	AC3
Number of Residues	9
Details	binding site for residue POP A 1003

Chain	Residue
A	ASN534
A	ARG536
A	ASP542
A	CA1001
A	CA1002
A	HOH1157
A	ARG352
A	LYS367
A	LYS370

---

site_id	AC4
Number of Residues	11
Details	binding site for residue AMP A 1004

Chain	Residue
A	HIS492
A	HIS494
A	ARG505
A	TYR506
A	GLN507
A	VAL510
A	GLN517
A	GLN519
A	GLY521
A	ASN733
A	ARG734

---

site_id	AC5
Number of Residues	3
Details	binding site for residue CA B 1001

Chain	Residue
B	ASP542
B	ASP545
B	POP1003

---

site_id	AC6
Number of Residues	3
Details	binding site for residue CA B 1002

Chain	Residue
B	ASN534
B	ASP542
B	POP1003

---

site_id	AC7
Number of Residues	8
Details	binding site for residue POP B 1003

Chain	Residue
B	ARG352
B	LYS367
B	ASN534
B	ARG536
B	ASP542
B	CA1001
B	CA1002
B	HOH1108

---

site_id	AC8
Number of Residues	11
Details	binding site for residue AMP B 1004

Chain	Residue
B	HIS492
B	ARG505
B	TYR506
B	GLN507
B	VAL510
B	GLN517
B	PHE518
B	GLN519
B	GLY521
B	ASN733
B	ARG734

---

site_id	AC9
Number of Residues	4
Details	binding site for residue CA C 201

Chain	Residue
C	ASP20
C	ASP22
C	ASP24
C	THR26

---

site_id	AD1
Number of Residues	5
Details	binding site for residue CA D 201

Chain	Residue
D	ASP20
D	ASP22
D	ASP24
D	THR26
D	HOH306

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
C	ASP20-LEU32
C	ASP56-PHE68
C	ASP93-LEU105
C	ASP129-PHE141

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585

Chain	Residue	Details
C	GLU31
C	ASP20
C	ASP22
C	ASP93
C	ASP95
C	ASN97
C	TYR99
C	GLU104
C	ASP129
C	ASP131
C	ASP133
C	GLN135
C	GLU140
D	ASP20
D	ASP22
D	ASP24
D	THR26
D	GLU31
D	ASP56
D	ASP58
D	ASN60
D	THR62
D	GLU67
D	ASP93
D	ASP95
D	ASN97
D	TYR99
D	GLU104
D	ASP129
D	ASP131
D	ASP133
D	GLN135
D	GLU140
C	ASP56
C	ASP58
C	ASN60
C	THR62
C	GLU67
C	ASP24
C	THR26

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N-acetylalanine => ECO:0000269|PubMed:7093203, ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712

Chain	Residue	Details
C	ALA1
D	ALA1

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
C	LYS21
D	LYS21

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP30

Chain	Residue	Details
C	THR44
D	THR44

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SER81
D	SER81

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
C	LYS94
D	LYS94

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332

Chain	Residue	Details
C	TYR99
D	TYR99

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
C	SER101
D	SER101

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
C	THR110
D	THR110

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315

Chain	Residue	Details
C	LYS115
D	LYS115

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
C	TYR138
D	TYR138

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157

Chain	Residue	Details
D	LYS21
C	LYS21

---