Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6PK4

cryoEM structure of the substrate-bound human CTP synthase 2 filament

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003883	molecular_function	CTP synthase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006220	biological_process	pyrimidine nucleotide metabolic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0044210	biological_process	'de novo' CTP biosynthetic process
A	0090407	biological_process	organophosphate biosynthetic process
A	0097268	cellular_component	cytoophidium
B	0003883	molecular_function	CTP synthase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006220	biological_process	pyrimidine nucleotide metabolic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0044210	biological_process	'de novo' CTP biosynthetic process
B	0090407	biological_process	organophosphate biosynthetic process
B	0097268	cellular_component	cytoophidium
C	0003883	molecular_function	CTP synthase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006220	biological_process	pyrimidine nucleotide metabolic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0042802	molecular_function	identical protein binding
C	0044210	biological_process	'de novo' CTP biosynthetic process
C	0090407	biological_process	organophosphate biosynthetic process
C	0097268	cellular_component	cytoophidium
D	0003883	molecular_function	CTP synthase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006220	biological_process	pyrimidine nucleotide metabolic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006241	biological_process	CTP biosynthetic process
D	0019856	biological_process	pyrimidine nucleobase biosynthetic process
D	0042802	molecular_function	identical protein binding
D	0044210	biological_process	'de novo' CTP biosynthetic process
D	0090407	biological_process	organophosphate biosynthetic process
D	0097268	cellular_component	cytoophidium

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue UTP A 601

Chain	Residue
A	SER12
B	LYS195
B	LYS229
C	GLN112
A	LYS38
A	TYR42
A	HIS55
A	ASP70
A	GLY149
A	ATP602
B	LYS193
B	THR194

site_id	AC2
Number of Residues	11
Details	binding site for residue ATP A 602

Chain	Residue
A	LYS16
A	GLY17
A	ILE18
A	LYS38
A	ASP70
A	GLU146
A	ARG217
A	VAL253
A	ASP312
A	UTP601
B	THR189

site_id	AC3
Number of Residues	11
Details	binding site for residue ATP B 602

Chain	Residue
A	THR189
B	LYS16
B	GLY17
B	ILE18
B	LYS38
B	ASP70
B	GLU146
B	ARG217
B	VAL253
B	ASP312
B	UTP601

site_id	AC4
Number of Residues	11
Details	binding site for residue ATP C 602

Chain	Residue
C	LYS16
C	GLY17
C	ILE18
C	LYS38
C	ASP70
C	GLU146
C	ARG217
C	VAL253
C	ASP312
C	UTP601
D	THR189

site_id	AC5
Number of Residues	11
Details	binding site for residue ATP D 602

Chain	Residue
C	THR189
D	LYS16
D	GLY17
D	ILE18
D	LYS38
D	ASP70
D	GLU146
D	ARG217
D	VAL253
D	ASP312
D	UTP601

site_id	AC6
Number of Residues	15
Details	binding site for Di-peptide UTP B 601 and HIS B 55

Chain	Residue
A	LYS193
A	THR194
A	LYS195
A	LYS229
B	SER12
B	LYS38
B	TYR42
B	TYR53
B	GLU54
B	GLY56
B	ASP68
B	ASP70
B	GLY149
B	ATP602
D	GLN112

site_id	AC7
Number of Residues	15
Details	binding site for Di-peptide UTP B 601 and HIS B 55

Chain	Residue
A	LYS193
A	THR194
A	LYS195
A	LYS229
B	SER12
B	LYS38
B	TYR42
B	TYR53
B	GLU54
B	GLY56
B	ASP68
B	ASP70
B	GLY149
B	ATP602
D	GLN112

site_id	AC8
Number of Residues	15
Details	binding site for Di-peptide UTP C 601 and HIS C 55

Chain	Residue
D	LYS195
D	LYS229
A	GLN112
C	SER12
C	LYS38
C	TYR42
C	TYR53
C	GLU54
C	GLY56
C	ASP68
C	ASP70
C	GLY149
C	ATP602
D	LYS193
D	THR194

site_id	AC9
Number of Residues	15
Details	binding site for Di-peptide UTP C 601 and HIS C 55

Chain	Residue
A	GLN112
C	SER12
C	LYS38
C	TYR42
C	TYR53
C	GLU54
C	GLY56
C	ASP68
C	ASP70
C	GLY149
C	ATP602
D	LYS193
D	THR194
D	LYS195
D	LYS229

site_id	AD1
Number of Residues	15
Details	binding site for Di-peptide UTP D 601 and HIS D 55

Chain	Residue
B	GLN112
C	LYS193
C	THR194
C	LYS195
C	LYS229
D	SER12
D	LYS38
D	TYR42
D	TYR53
D	GLU54
D	GLY56
D	ASP68
D	ASP70
D	GLY149
D	ATP602

site_id	AD2
Number of Residues	15
Details	binding site for Di-peptide UTP D 601 and HIS D 55

Chain	Residue
B	GLN112
C	LYS193
C	THR194
C	LYS195
C	LYS229
D	SER12
D	LYS38
D	TYR42
D	TYR53
D	GLU54
D	GLY56
D	ASP68
D	ASP70
D	GLY149
D	ATP602

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1016
Details	Domain: {"description":"Glutamine amidotransferase type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00605","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Active site: {"description":"For GATase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00605","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31873303","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6PK4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MII","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MH1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MII","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31873303","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6PK4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31873303","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6PK7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31873303","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6PK4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MIH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31873303","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PK7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31873303","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PK7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7MH1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MII","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34583994","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7MIH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)