6PIX
Crystal structure of HCV NS3/4A D168A protease in complex with P4-P5-5 (WK-25)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0019062 | biological_process | virion attachment to host cell |
| A | 0019087 | biological_process | transformation of host cell by virus |
| A | 0033644 | cellular_component | host cell membrane |
| A | 0044423 | cellular_component | virion component |
| A | 0046718 | biological_process | symbiont entry into host cell |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1201 |
| Chain | Residue |
| A | CYS1097 |
| A | CYS1099 |
| A | CYS1145 |
| A | HIS1149 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | binding site for residue OLY A 1202 |
| Chain | Residue |
| A | VAL1078 |
| A | ASP1081 |
| A | LEU1135 |
| A | LYS1136 |
| A | GLY1137 |
| A | SER1138 |
| A | SER1139 |
| A | PHE1154 |
| A | ARG1155 |
| A | ALA1156 |
| A | ALA1157 |
| A | SO41204 |
| A | HOH1357 |
| A | HOH1361 |
| A | HOH1362 |
| A | HOH1380 |
| A | HOH1403 |
| A | GLN1041 |
| A | THR1042 |
| A | PHE1043 |
| A | TYR1056 |
| A | HIS1057 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1203 |
| Chain | Residue |
| A | LYS989 |
| A | THR1040 |
| A | GLN1041 |
| A | ARG1062 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 1204 |
| Chain | Residue |
| A | TYR1006 |
| A | GLN1008 |
| A | TYR1056 |
| A | OLY1202 |
| A | HOH1343 |
| A | HOH1355 |
| A | HOH1401 |
| A | HOH1415 |
