6PIC
Crystal structure of Marinobacter subterrani acetylpolyamine amidohydrolase (msAPAH) complexed with 6-amino-N-hydroxyhexanamide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004407 | molecular_function | histone deacetylase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0040029 | biological_process | epigenetic regulation of gene expression |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004407 | molecular_function | histone deacetylase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0040029 | biological_process | epigenetic regulation of gene expression |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004407 | molecular_function | histone deacetylase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0040029 | biological_process | epigenetic regulation of gene expression |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004407 | molecular_function | histone deacetylase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0040029 | biological_process | epigenetic regulation of gene expression |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0004407 | molecular_function | histone deacetylase activity |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0040029 | biological_process | epigenetic regulation of gene expression |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0004407 | molecular_function | histone deacetylase activity |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0040029 | biological_process | epigenetic regulation of gene expression |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0004407 | molecular_function | histone deacetylase activity |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0040029 | biological_process | epigenetic regulation of gene expression |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0004407 | molecular_function | histone deacetylase activity |
| H | 0016787 | molecular_function | hydrolase activity |
| H | 0040029 | biological_process | epigenetic regulation of gene expression |
| H | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | ASP195 |
| A | HIS197 |
| A | ASP284 |
| A | 6XA405 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue K A 402 |
| Chain | Residue |
| A | ASP193 |
| A | ASP195 |
| A | HIS197 |
| A | SER216 |
| A | LEU217 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue K A 403 |
| Chain | Residue |
| A | PHE206 |
| A | ARG209 |
| A | VAL212 |
| A | TYR243 |
| A | HOH506 |
| A | HOH510 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 404 |
| Chain | Residue |
| A | LYS83 |
| A | ASP104 |
| A | ASP106 |
| A | HOH502 |
| A | HOH576 |
| A | HOH582 |
| A | HOH591 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | binding site for residue 6XA A 405 |
| Chain | Residue |
| A | GLU17 |
| A | ASP117 |
| A | HIS158 |
| A | HIS159 |
| A | TYR168 |
| A | ASP195 |
| A | HIS197 |
| A | PHE225 |
| A | ASP284 |
| A | TYR323 |
| A | ZN401 |
| A | HOH523 |
| C | PHE91 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 401 |
| Chain | Residue |
| B | ASP195 |
| B | HIS197 |
| B | ASP284 |
| B | 6XA405 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue K B 402 |
| Chain | Residue |
| B | ASP193 |
| B | ASP195 |
| B | HIS197 |
| B | SER216 |
| B | LEU217 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue K B 403 |
| Chain | Residue |
| B | PHE206 |
| B | ARG209 |
| B | VAL212 |
| B | TYR243 |
| B | HOH503 |
| B | HOH521 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 404 |
| Chain | Residue |
| B | ASP104 |
| B | ASP106 |
| B | HOH504 |
| B | HOH506 |
| B | HOH561 |
| B | HOH573 |
| site_id | AD1 |
| Number of Residues | 13 |
| Details | binding site for residue 6XA B 405 |
| Chain | Residue |
| B | GLU17 |
| B | ASP117 |
| B | HIS158 |
| B | HIS159 |
| B | TYR168 |
| B | ASP195 |
| B | HIS197 |
| B | PHE225 |
| B | ASP284 |
| B | TYR323 |
| B | ZN401 |
| B | HOH511 |
| H | PHE91 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 401 |
| Chain | Residue |
| C | ASP195 |
| C | HIS197 |
| C | ASP284 |
| C | 6XA405 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue K C 402 |
| Chain | Residue |
| C | ASP193 |
| C | ASP195 |
| C | HIS197 |
| C | SER216 |
| C | LEU217 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue K C 403 |
| Chain | Residue |
| C | PHE206 |
| C | ARG209 |
| C | VAL212 |
| C | TYR243 |
| C | HOH513 |
| C | HOH525 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 404 |
| Chain | Residue |
| C | ASP104 |
| C | ASP106 |
| C | HOH510 |
| C | HOH561 |
| C | HOH567 |
| C | HOH578 |
| site_id | AD6 |
| Number of Residues | 14 |
| Details | binding site for residue 6XA C 405 |
| Chain | Residue |
| C | ASP284 |
| C | TYR323 |
| C | ZN401 |
| C | HOH519 |
| C | HOH521 |
| A | PHE91 |
| C | GLU17 |
| C | ASP117 |
| C | HIS158 |
| C | HIS159 |
| C | GLY167 |
| C | TYR168 |
| C | ASP195 |
| C | HIS197 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 401 |
| Chain | Residue |
| D | ASP195 |
| D | HIS197 |
| D | ASP284 |
| D | 6XA405 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue K D 402 |
| Chain | Residue |
| D | ASP193 |
| D | ASP195 |
| D | HIS197 |
| D | SER216 |
| D | LEU217 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue K D 403 |
| Chain | Residue |
| D | PHE206 |
| D | ARG209 |
| D | VAL212 |
| D | TYR243 |
| D | HOH507 |
| D | HOH523 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 404 |
| Chain | Residue |
| D | ASP104 |
| D | ASP106 |
| D | HOH502 |
| D | HOH549 |
| D | HOH561 |
| D | HOH571 |
| site_id | AE2 |
| Number of Residues | 13 |
| Details | binding site for residue 6XA D 405 |
| Chain | Residue |
| D | GLU17 |
| D | ASP117 |
| D | HIS158 |
| D | HIS159 |
| D | TYR168 |
| D | ASP195 |
| D | HIS197 |
| D | ASP284 |
| D | TYR323 |
| D | ZN401 |
| D | HOH501 |
| D | HOH562 |
| F | PHE91 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 401 |
| Chain | Residue |
| E | ASP195 |
| E | HIS197 |
| E | ASP284 |
| E | 6XA405 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue K E 402 |
| Chain | Residue |
| E | ASP193 |
| E | ASP195 |
| E | HIS197 |
| E | SER216 |
| E | LEU217 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue K E 403 |
| Chain | Residue |
| E | PHE206 |
| E | ARG209 |
| E | VAL212 |
| E | TYR243 |
| E | HOH507 |
| E | HOH522 |
| site_id | AE6 |
| Number of Residues | 7 |
| Details | binding site for residue MG E 404 |
| Chain | Residue |
| E | LYS83 |
| E | ASP104 |
| E | ASP106 |
| E | HOH514 |
| E | HOH546 |
| E | HOH573 |
| E | HOH576 |
| site_id | AE7 |
| Number of Residues | 13 |
| Details | binding site for residue 6XA E 405 |
| Chain | Residue |
| E | GLU17 |
| E | ASP117 |
| E | HIS158 |
| E | HIS159 |
| E | TYR168 |
| E | ASP195 |
| E | HIS197 |
| E | PHE225 |
| E | ASP284 |
| E | TYR323 |
| E | ZN401 |
| E | HOH512 |
| G | PHE91 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN F 401 |
| Chain | Residue |
| F | ASP195 |
| F | HIS197 |
| F | ASP284 |
| F | 6XA405 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue K F 402 |
| Chain | Residue |
| F | ASP193 |
| F | ASP195 |
| F | HIS197 |
| F | SER216 |
| F | LEU217 |
| site_id | AF1 |
| Number of Residues | 6 |
| Details | binding site for residue K F 403 |
| Chain | Residue |
| F | PHE206 |
| F | ARG209 |
| F | VAL212 |
| F | TYR243 |
| F | HOH519 |
| F | HOH536 |
| site_id | AF2 |
| Number of Residues | 6 |
| Details | binding site for residue MG F 404 |
| Chain | Residue |
| F | ASP104 |
| F | ASP106 |
| F | HOH505 |
| F | HOH565 |
| F | HOH579 |
| F | HOH584 |
| site_id | AF3 |
| Number of Residues | 13 |
| Details | binding site for residue 6XA F 405 |
| Chain | Residue |
| D | PHE91 |
| F | GLU17 |
| F | ASP117 |
| F | HIS158 |
| F | HIS159 |
| F | GLY167 |
| F | TYR168 |
| F | ASP195 |
| F | HIS197 |
| F | ASP284 |
| F | TYR323 |
| F | ZN401 |
| F | HOH509 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN G 401 |
| Chain | Residue |
| G | ASP195 |
| G | HIS197 |
| G | ASP284 |
| G | 6XA405 |
| site_id | AF5 |
| Number of Residues | 5 |
| Details | binding site for residue K G 402 |
| Chain | Residue |
| G | ASP193 |
| G | ASP195 |
| G | HIS197 |
| G | SER216 |
| G | LEU217 |
| site_id | AF6 |
| Number of Residues | 6 |
| Details | binding site for residue K G 403 |
| Chain | Residue |
| G | PHE206 |
| G | ARG209 |
| G | VAL212 |
| G | TYR243 |
| G | HOH515 |
| G | HOH525 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue MG G 404 |
| Chain | Residue |
| G | ASP104 |
| G | ASP106 |
| G | HOH522 |
| G | HOH538 |
| G | HOH561 |
| G | HOH563 |
| site_id | AF8 |
| Number of Residues | 13 |
| Details | binding site for residue 6XA G 405 |
| Chain | Residue |
| G | GLU17 |
| G | ASP117 |
| G | HIS158 |
| G | HIS159 |
| G | GLY167 |
| G | TYR168 |
| G | ASP195 |
| G | HIS197 |
| G | PHE225 |
| G | ASP284 |
| G | TYR323 |
| G | ZN401 |
| G | HOH518 |
| site_id | AF9 |
| Number of Residues | 4 |
| Details | binding site for residue ZN H 401 |
| Chain | Residue |
| H | ASP195 |
| H | HIS197 |
| H | ASP284 |
| H | 6XA405 |
| site_id | AG1 |
| Number of Residues | 5 |
| Details | binding site for residue K H 402 |
| Chain | Residue |
| H | ASP193 |
| H | ASP195 |
| H | HIS197 |
| H | SER216 |
| H | LEU217 |
| site_id | AG2 |
| Number of Residues | 6 |
| Details | binding site for residue K H 403 |
| Chain | Residue |
| H | PHE206 |
| H | ARG209 |
| H | VAL212 |
| H | TYR243 |
| H | HOH509 |
| H | HOH515 |
| site_id | AG3 |
| Number of Residues | 6 |
| Details | binding site for residue MG H 404 |
| Chain | Residue |
| H | ASP104 |
| H | ASP106 |
| H | HOH525 |
| H | HOH561 |
| H | HOH566 |
| H | HOH567 |
| site_id | AG4 |
| Number of Residues | 13 |
| Details | binding site for residue 6XA H 405 |
| Chain | Residue |
| B | PHE91 |
| H | GLU17 |
| H | ASP117 |
| H | HIS158 |
| H | HIS159 |
| H | TYR168 |
| H | ASP195 |
| H | HIS197 |
| H | PHE225 |
| H | ASP284 |
| H | TYR323 |
| H | ZN401 |
| H | HOH502 |
