6PGW

Crystal structure of zebrafish Protocadherin-19 EC3-6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0005886	cellular_component	plasma membrane
A	0007155	biological_process	cell adhesion
A	0007156	biological_process	homophilic cell adhesion via plasma membrane adhesion molecules
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA A 701

Chain	Residue
A	GLU226
A	ASP282
A	GLU284
A	ASP318
A	HOH809
A	HOH810

---

site_id	AC2
Number of Residues	6
Details	binding site for residue CA A 702

Chain	Residue
A	ILE316
A	ASP318
A	ASP354
A	GLU226
A	GLU284
A	ASP315

---

site_id	AC3
Number of Residues	6
Details	binding site for residue CA A 703

Chain	Residue
A	ASN317
A	ASN319
A	ASP352
A	ASP354
A	ASN358
A	ASP404

---

site_id	AC4
Number of Residues	6
Details	binding site for residue CA A 704

Chain	Residue
A	GLU337
A	ASP389
A	GLU391
A	ASP425
A	HOH801
A	HOH804

---

site_id	AC5
Number of Residues	6
Details	binding site for residue CA A 705

Chain	Residue
A	GLU337
A	GLU391
A	ASP422
A	GLU423
A	ASP425
A	ASP458

---

site_id	AC6
Number of Residues	6
Details	binding site for residue CA A 706

Chain	Residue
A	ASN424
A	ASN426
A	ASP456
A	ASP458
A	ASN462
A	ASP513

---

site_id	AC7
Number of Residues	6
Details	binding site for residue CA A 707

Chain	Residue
A	GLU441
A	ASN498
A	GLU500
A	ASP534
A	HOH803
A	HOH812

---

site_id	AC8
Number of Residues	6
Details	binding site for residue CA A 708

Chain	Residue
A	GLU441
A	GLU500
A	ASP531
A	VAL532
A	ASP534
A	ASP572

---

site_id	AC9
Number of Residues	6
Details	binding site for residue CA A 709

Chain	Residue
A	ASN533
A	ASN535
A	ASP570
A	ASP572
A	ASN576
A	ASP622

---

site_id	AD1
Number of Residues	4
Details	binding site for residue NA A 710

Chain	Residue
A	ASP236
A	LEU237
A	THR272
A	HOH815

---

Functional Information from PROSITE/UniProt

site_id	PS00232
Number of Residues	11
Details	CADHERIN_1 Cadherin domain signature. VnViDiNDNaP

Chain	Residue	Details
A	VAL311-PRO321
A	VAL418-PRO428
A	ILE527-PRO537

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:27787195, ECO:0000269|PubMed:34520737, ECO:0000312|PDB:6PGW, ECO:0007744|PDB:5IU9

Chain	Residue	Details
A	GLU226
A	ASP354
A	ASN358
A	ASP404
A	ASP282
A	GLU284
A	ASP315
A	ILE316
A	ASN317
A	ASP318
A	ASN319
A	ASP352

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:27787195, ECO:0007744|PDB:5IU9

Chain	Residue	Details
A	ASP241
A	ASP243
A	ASN247

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:34520737, ECO:0007744|PDB:6PGW

Chain	Residue	Details
A	GLU337
A	ASP456
A	ASP458
A	ASN462
A	ASN498
A	GLU500
A	ASP513
A	ASP531
A	VAL532
A	ASN533
A	ASP534
A	ASP389
A	ASN535
A	ASP570
A	ASP572
A	ASN576
A	ASP622
A	GLU391
A	ASP422
A	GLU423
A	ASN424
A	ASP425
A	ASN426
A	GLU441

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498

Chain	Residue	Details
A	ASN238
A	ASN260
A	ASN353
A	ASN397
A	ASN462
A	ASN522
A	ASN546

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