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6PES

Cryo-EM structure of alpha-synuclein H50Q Wide Fibril

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000149molecular_functionSNARE binding
A0000287molecular_functionmagnesium ion binding
A0000976molecular_functiontranscription cis-regulatory region binding
A0001774biological_processmicroglial cell activation
A0001921biological_processpositive regulation of receptor recycling
A0001956biological_processpositive regulation of neurotransmitter secretion
A0001963biological_processsynaptic transmission, dopaminergic
A0003779molecular_functionactin binding
A0004860molecular_functionprotein kinase inhibitor activity
A0005504molecular_functionfatty acid binding
A0005507molecular_functioncopper ion binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005543molecular_functionphospholipid binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005764cellular_componentlysosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0006469biological_processnegative regulation of protein kinase activity
A0006631biological_processfatty acid metabolic process
A0006638biological_processneutral lipid metabolic process
A0006644biological_processphospholipid metabolic process
A0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
A0007006biological_processmitochondrial membrane organization
A0007268biological_processchemical synaptic transmission
A0007269biological_processneurotransmitter secretion
A0008198molecular_functionferrous iron binding
A0008270molecular_functionzinc ion binding
A0008289molecular_functionlipid binding
A0008344biological_processadult locomotory behavior
A0009410biological_processresponse to xenobiotic stimulus
A0010040biological_processresponse to iron(II) ion
A0010517biological_processregulation of phospholipase activity
A0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
A0014048biological_processregulation of glutamate secretion
A0014059biological_processregulation of dopamine secretion
A0015629cellular_componentactin cytoskeleton
A0016020cellular_componentmembrane
A0016079biological_processsynaptic vesicle exocytosis
A0016082biological_processsynaptic vesicle priming
A0016234cellular_componentinclusion body
A0016491molecular_functionoxidoreductase activity
A0019894molecular_functionkinesin binding
A0022898biological_processregulation of transmembrane transporter activity
A0030424cellular_componentaxon
A0030426cellular_componentgrowth cone
A0030544molecular_functionHsp70 protein binding
A0030672cellular_componentsynaptic vesicle membrane
A0031092cellular_componentplatelet alpha granule membrane
A0031115biological_processnegative regulation of microtubule polymerization
A0031623biological_processreceptor internalization
A0031648biological_processprotein destabilization
A0032026biological_processresponse to magnesium ion
A0032410biological_processnegative regulation of transporter activity
A0032496biological_processresponse to lipopolysaccharide
A0032769biological_processnegative regulation of monooxygenase activity
A0032991cellular_componentprotein-containing complex
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0034341biological_processresponse to type II interferon
A0034599biological_processcellular response to oxidative stress
A0035493biological_processSNARE complex assembly
A0035543biological_processpositive regulation of SNARE complex assembly
A0040012biological_processregulation of locomotion
A0042393molecular_functionhistone binding
A0042416biological_processdopamine biosynthetic process
A0042417biological_processdopamine metabolic process
A0042775biological_processmitochondrial ATP synthesis coupled electron transport
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043014molecular_functionalpha-tubulin binding
A0043025cellular_componentneuronal cell body
A0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
A0043030biological_processregulation of macrophage activation
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A0043524biological_processnegative regulation of neuron apoptotic process
A0043679cellular_componentaxon terminus
A0045202cellular_componentsynapse
A0045807biological_processpositive regulation of endocytosis
A0045920biological_processnegative regulation of exocytosis
A0045921biological_processpositive regulation of exocytosis
A0046872molecular_functionmetal ion binding
A0046928biological_processregulation of neurotransmitter secretion
A0048156molecular_functiontau protein binding
A0048168biological_processregulation of neuronal synaptic plasticity
A0048169biological_processregulation of long-term neuronal synaptic plasticity
A0048471cellular_componentperinuclear region of cytoplasm
A0048488biological_processsynaptic vesicle endocytosis
A0048489biological_processsynaptic vesicle transport
A0050729biological_processpositive regulation of inflammatory response
A0050806biological_processpositive regulation of synaptic transmission
A0050808biological_processsynapse organization
A0050812biological_processregulation of acyl-CoA biosynthetic process
A0051219molecular_functionphosphoprotein binding
A0051259biological_processprotein complex oligomerization
A0051262biological_processprotein tetramerization
A0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
A0051402biological_processneuron apoptotic process
A0051583biological_processdopamine uptake involved in synaptic transmission
A0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
A0051612biological_processnegative regulation of serotonin uptake
A0051621biological_processregulation of norepinephrine uptake
A0051622biological_processnegative regulation of norepinephrine uptake
A0055074biological_processcalcium ion homeostasis
A0060079biological_processexcitatory postsynaptic potential
A0060090molecular_functionmolecular adaptor activity
A0060291biological_processlong-term synaptic potentiation
A0060732biological_processpositive regulation of inositol phosphate biosynthetic process
A0060961molecular_functionphospholipase D inhibitor activity
A0061024biological_processmembrane organization
A0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
A0070555biological_processresponse to interleukin-1
A0070840molecular_functiondynein complex binding
A0071280biological_processcellular response to copper ion
A0071872biological_processcellular response to epinephrine stimulus
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0097435biological_processsupramolecular fiber organization
A0098794cellular_componentpostsynapse
A0099512cellular_componentsupramolecular fiber
A1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
A1903136molecular_functioncuprous ion binding
A1903284biological_processpositive regulation of glutathione peroxidase activity
A1903285biological_processpositive regulation of hydrogen peroxide catabolic process
A1903421biological_processregulation of synaptic vesicle recycling
A1903426biological_processregulation of reactive oxygen species biosynthetic process
A1904377biological_processpositive regulation of protein localization to cell periphery
A1904715biological_processnegative regulation of chaperone-mediated autophagy
A1905606biological_processregulation of presynapse assembly
A1990000biological_processamyloid fibril formation
A2000377biological_processregulation of reactive oxygen species metabolic process
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000149molecular_functionSNARE binding
B0000287molecular_functionmagnesium ion binding
B0000976molecular_functiontranscription cis-regulatory region binding
B0001774biological_processmicroglial cell activation
B0001921biological_processpositive regulation of receptor recycling
B0001956biological_processpositive regulation of neurotransmitter secretion
B0001963biological_processsynaptic transmission, dopaminergic
B0003779molecular_functionactin binding
B0004860molecular_functionprotein kinase inhibitor activity
B0005504molecular_functionfatty acid binding
B0005507molecular_functioncopper ion binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005543molecular_functionphospholipid binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005764cellular_componentlysosome
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005938cellular_componentcell cortex
B0006469biological_processnegative regulation of protein kinase activity
B0006631biological_processfatty acid metabolic process
B0006638biological_processneutral lipid metabolic process
B0006644biological_processphospholipid metabolic process
B0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
B0007006biological_processmitochondrial membrane organization
B0007268biological_processchemical synaptic transmission
B0007269biological_processneurotransmitter secretion
B0008198molecular_functionferrous iron binding
B0008270molecular_functionzinc ion binding
B0008289molecular_functionlipid binding
B0008344biological_processadult locomotory behavior
B0009410biological_processresponse to xenobiotic stimulus
B0010040biological_processresponse to iron(II) ion
B0010517biological_processregulation of phospholipase activity
B0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
B0014048biological_processregulation of glutamate secretion
B0014059biological_processregulation of dopamine secretion
B0015629cellular_componentactin cytoskeleton
B0016020cellular_componentmembrane
B0016079biological_processsynaptic vesicle exocytosis
B0016082biological_processsynaptic vesicle priming
B0016234cellular_componentinclusion body
B0016491molecular_functionoxidoreductase activity
B0019894molecular_functionkinesin binding
B0022898biological_processregulation of transmembrane transporter activity
B0030424cellular_componentaxon
B0030426cellular_componentgrowth cone
B0030544molecular_functionHsp70 protein binding
B0030672cellular_componentsynaptic vesicle membrane
B0031092cellular_componentplatelet alpha granule membrane
B0031115biological_processnegative regulation of microtubule polymerization
B0031623biological_processreceptor internalization
B0031648biological_processprotein destabilization
B0032026biological_processresponse to magnesium ion
B0032410biological_processnegative regulation of transporter activity
B0032496biological_processresponse to lipopolysaccharide
B0032769biological_processnegative regulation of monooxygenase activity
B0032991cellular_componentprotein-containing complex
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0034341biological_processresponse to type II interferon
B0034599biological_processcellular response to oxidative stress
B0035493biological_processSNARE complex assembly
B0035543biological_processpositive regulation of SNARE complex assembly
B0040012biological_processregulation of locomotion
B0042393molecular_functionhistone binding
B0042416biological_processdopamine biosynthetic process
B0042417biological_processdopamine metabolic process
B0042775biological_processmitochondrial ATP synthesis coupled electron transport
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043014molecular_functionalpha-tubulin binding
B0043025cellular_componentneuronal cell body
B0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
B0043030biological_processregulation of macrophage activation
B0043065biological_processpositive regulation of apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
B0043524biological_processnegative regulation of neuron apoptotic process
B0043679cellular_componentaxon terminus
B0045202cellular_componentsynapse
B0045807biological_processpositive regulation of endocytosis
B0045920biological_processnegative regulation of exocytosis
B0045921biological_processpositive regulation of exocytosis
B0046872molecular_functionmetal ion binding
B0046928biological_processregulation of neurotransmitter secretion
B0048156molecular_functiontau protein binding
B0048168biological_processregulation of neuronal synaptic plasticity
B0048169biological_processregulation of long-term neuronal synaptic plasticity
B0048471cellular_componentperinuclear region of cytoplasm
B0048488biological_processsynaptic vesicle endocytosis
B0048489biological_processsynaptic vesicle transport
B0050729biological_processpositive regulation of inflammatory response
B0050806biological_processpositive regulation of synaptic transmission
B0050808biological_processsynapse organization
B0050812biological_processregulation of acyl-CoA biosynthetic process
B0051219molecular_functionphosphoprotein binding
B0051259biological_processprotein complex oligomerization
B0051262biological_processprotein tetramerization
B0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
B0051402biological_processneuron apoptotic process
B0051583biological_processdopamine uptake involved in synaptic transmission
B0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
B0051612biological_processnegative regulation of serotonin uptake
B0051621biological_processregulation of norepinephrine uptake
B0051622biological_processnegative regulation of norepinephrine uptake
B0055074biological_processcalcium ion homeostasis
B0060079biological_processexcitatory postsynaptic potential
B0060090molecular_functionmolecular adaptor activity
B0060291biological_processlong-term synaptic potentiation
B0060732biological_processpositive regulation of inositol phosphate biosynthetic process
B0060961molecular_functionphospholipase D inhibitor activity
B0061024biological_processmembrane organization
B0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
B0070555biological_processresponse to interleukin-1
B0070840molecular_functiondynein complex binding
B0071280biological_processcellular response to copper ion
B0071872biological_processcellular response to epinephrine stimulus
B0071902biological_processpositive regulation of protein serine/threonine kinase activity
B0097435biological_processsupramolecular fiber organization
B0098794cellular_componentpostsynapse
B0099512cellular_componentsupramolecular fiber
B1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
B1903136molecular_functioncuprous ion binding
B1903284biological_processpositive regulation of glutathione peroxidase activity
B1903285biological_processpositive regulation of hydrogen peroxide catabolic process
B1903421biological_processregulation of synaptic vesicle recycling
B1903426biological_processregulation of reactive oxygen species biosynthetic process
B1904377biological_processpositive regulation of protein localization to cell periphery
B1904715biological_processnegative regulation of chaperone-mediated autophagy
B1905606biological_processregulation of presynapse assembly
B1990000biological_processamyloid fibril formation
B2000377biological_processregulation of reactive oxygen species metabolic process
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000149molecular_functionSNARE binding
C0000287molecular_functionmagnesium ion binding
C0000976molecular_functiontranscription cis-regulatory region binding
C0001774biological_processmicroglial cell activation
C0001921biological_processpositive regulation of receptor recycling
C0001956biological_processpositive regulation of neurotransmitter secretion
C0001963biological_processsynaptic transmission, dopaminergic
C0003779molecular_functionactin binding
C0004860molecular_functionprotein kinase inhibitor activity
C0005504molecular_functionfatty acid binding
C0005507molecular_functioncopper ion binding
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005543molecular_functionphospholipid binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005764cellular_componentlysosome
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0005938cellular_componentcell cortex
C0006469biological_processnegative regulation of protein kinase activity
C0006631biological_processfatty acid metabolic process
C0006638biological_processneutral lipid metabolic process
C0006644biological_processphospholipid metabolic process
C0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
C0007006biological_processmitochondrial membrane organization
C0007268biological_processchemical synaptic transmission
C0007269biological_processneurotransmitter secretion
C0008198molecular_functionferrous iron binding
C0008270molecular_functionzinc ion binding
C0008289molecular_functionlipid binding
C0008344biological_processadult locomotory behavior
C0009410biological_processresponse to xenobiotic stimulus
C0010040biological_processresponse to iron(II) ion
C0010517biological_processregulation of phospholipase activity
C0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
C0014048biological_processregulation of glutamate secretion
C0014059biological_processregulation of dopamine secretion
C0015629cellular_componentactin cytoskeleton
C0016020cellular_componentmembrane
C0016079biological_processsynaptic vesicle exocytosis
C0016082biological_processsynaptic vesicle priming
C0016234cellular_componentinclusion body
C0016491molecular_functionoxidoreductase activity
C0019894molecular_functionkinesin binding
C0022898biological_processregulation of transmembrane transporter activity
C0030424cellular_componentaxon
C0030426cellular_componentgrowth cone
C0030544molecular_functionHsp70 protein binding
C0030672cellular_componentsynaptic vesicle membrane
C0031092cellular_componentplatelet alpha granule membrane
C0031115biological_processnegative regulation of microtubule polymerization
C0031623biological_processreceptor internalization
C0031648biological_processprotein destabilization
C0032026biological_processresponse to magnesium ion
C0032410biological_processnegative regulation of transporter activity
C0032496biological_processresponse to lipopolysaccharide
C0032769biological_processnegative regulation of monooxygenase activity
C0032991cellular_componentprotein-containing complex
C0033138biological_processpositive regulation of peptidyl-serine phosphorylation
C0034341biological_processresponse to type II interferon
C0034599biological_processcellular response to oxidative stress
C0035493biological_processSNARE complex assembly
C0035543biological_processpositive regulation of SNARE complex assembly
C0040012biological_processregulation of locomotion
C0042393molecular_functionhistone binding
C0042416biological_processdopamine biosynthetic process
C0042417biological_processdopamine metabolic process
C0042775biological_processmitochondrial ATP synthesis coupled electron transport
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0043014molecular_functionalpha-tubulin binding
C0043025cellular_componentneuronal cell body
C0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
C0043030biological_processregulation of macrophage activation
C0043065biological_processpositive regulation of apoptotic process
C0043066biological_processnegative regulation of apoptotic process
C0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
C0043524biological_processnegative regulation of neuron apoptotic process
C0043679cellular_componentaxon terminus
C0045202cellular_componentsynapse
C0045807biological_processpositive regulation of endocytosis
C0045920biological_processnegative regulation of exocytosis
C0045921biological_processpositive regulation of exocytosis
C0046872molecular_functionmetal ion binding
C0046928biological_processregulation of neurotransmitter secretion
C0048156molecular_functiontau protein binding
C0048168biological_processregulation of neuronal synaptic plasticity
C0048169biological_processregulation of long-term neuronal synaptic plasticity
C0048471cellular_componentperinuclear region of cytoplasm
C0048488biological_processsynaptic vesicle endocytosis
C0048489biological_processsynaptic vesicle transport
C0050729biological_processpositive regulation of inflammatory response
C0050806biological_processpositive regulation of synaptic transmission
C0050808biological_processsynapse organization
C0050812biological_processregulation of acyl-CoA biosynthetic process
C0051219molecular_functionphosphoprotein binding
C0051259biological_processprotein complex oligomerization
C0051262biological_processprotein tetramerization
C0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
C0051402biological_processneuron apoptotic process
C0051583biological_processdopamine uptake involved in synaptic transmission
C0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
C0051612biological_processnegative regulation of serotonin uptake
C0051621biological_processregulation of norepinephrine uptake
C0051622biological_processnegative regulation of norepinephrine uptake
C0055074biological_processcalcium ion homeostasis
C0060079biological_processexcitatory postsynaptic potential
C0060090molecular_functionmolecular adaptor activity
C0060291biological_processlong-term synaptic potentiation
C0060732biological_processpositive regulation of inositol phosphate biosynthetic process
C0060961molecular_functionphospholipase D inhibitor activity
C0061024biological_processmembrane organization
C0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
C0070555biological_processresponse to interleukin-1
C0070840molecular_functiondynein complex binding
C0071280biological_processcellular response to copper ion
C0071872biological_processcellular response to epinephrine stimulus
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0097435biological_processsupramolecular fiber organization
C0098794cellular_componentpostsynapse
C0099512cellular_componentsupramolecular fiber
C1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
C1903136molecular_functioncuprous ion binding
C1903284biological_processpositive regulation of glutathione peroxidase activity
C1903285biological_processpositive regulation of hydrogen peroxide catabolic process
C1903421biological_processregulation of synaptic vesicle recycling
C1903426biological_processregulation of reactive oxygen species biosynthetic process
C1904377biological_processpositive regulation of protein localization to cell periphery
C1904715biological_processnegative regulation of chaperone-mediated autophagy
C1905606biological_processregulation of presynapse assembly
C1990000biological_processamyloid fibril formation
C2000377biological_processregulation of reactive oxygen species metabolic process
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000149molecular_functionSNARE binding
D0000287molecular_functionmagnesium ion binding
D0000976molecular_functiontranscription cis-regulatory region binding
D0001774biological_processmicroglial cell activation
D0001921biological_processpositive regulation of receptor recycling
D0001956biological_processpositive regulation of neurotransmitter secretion
D0001963biological_processsynaptic transmission, dopaminergic
D0003779molecular_functionactin binding
D0004860molecular_functionprotein kinase inhibitor activity
D0005504molecular_functionfatty acid binding
D0005507molecular_functioncopper ion binding
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005543molecular_functionphospholipid binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005764cellular_componentlysosome
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0005938cellular_componentcell cortex
D0006469biological_processnegative regulation of protein kinase activity
D0006631biological_processfatty acid metabolic process
D0006638biological_processneutral lipid metabolic process
D0006644biological_processphospholipid metabolic process
D0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
D0007006biological_processmitochondrial membrane organization
D0007268biological_processchemical synaptic transmission
D0007269biological_processneurotransmitter secretion
D0008198molecular_functionferrous iron binding
D0008270molecular_functionzinc ion binding
D0008289molecular_functionlipid binding
D0008344biological_processadult locomotory behavior
D0009410biological_processresponse to xenobiotic stimulus
D0010040biological_processresponse to iron(II) ion
D0010517biological_processregulation of phospholipase activity
D0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
D0014048biological_processregulation of glutamate secretion
D0014059biological_processregulation of dopamine secretion
D0015629cellular_componentactin cytoskeleton
D0016020cellular_componentmembrane
D0016079biological_processsynaptic vesicle exocytosis
D0016082biological_processsynaptic vesicle priming
D0016234cellular_componentinclusion body
D0016491molecular_functionoxidoreductase activity
D0019894molecular_functionkinesin binding
D0022898biological_processregulation of transmembrane transporter activity
D0030424cellular_componentaxon
D0030426cellular_componentgrowth cone
D0030544molecular_functionHsp70 protein binding
D0030672cellular_componentsynaptic vesicle membrane
D0031092cellular_componentplatelet alpha granule membrane
D0031115biological_processnegative regulation of microtubule polymerization
D0031623biological_processreceptor internalization
D0031648biological_processprotein destabilization
D0032026biological_processresponse to magnesium ion
D0032410biological_processnegative regulation of transporter activity
D0032496biological_processresponse to lipopolysaccharide
D0032769biological_processnegative regulation of monooxygenase activity
D0032991cellular_componentprotein-containing complex
D0033138biological_processpositive regulation of peptidyl-serine phosphorylation
D0034341biological_processresponse to type II interferon
D0034599biological_processcellular response to oxidative stress
D0035493biological_processSNARE complex assembly
D0035543biological_processpositive regulation of SNARE complex assembly
D0040012biological_processregulation of locomotion
D0042393molecular_functionhistone binding
D0042416biological_processdopamine biosynthetic process
D0042417biological_processdopamine metabolic process
D0042775biological_processmitochondrial ATP synthesis coupled electron transport
D0042802molecular_functionidentical protein binding
D0042995cellular_componentcell projection
D0043014molecular_functionalpha-tubulin binding
D0043025cellular_componentneuronal cell body
D0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
D0043030biological_processregulation of macrophage activation
D0043065biological_processpositive regulation of apoptotic process
D0043066biological_processnegative regulation of apoptotic process
D0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
D0043524biological_processnegative regulation of neuron apoptotic process
D0043679cellular_componentaxon terminus
D0045202cellular_componentsynapse
D0045807biological_processpositive regulation of endocytosis
D0045920biological_processnegative regulation of exocytosis
D0045921biological_processpositive regulation of exocytosis
D0046872molecular_functionmetal ion binding
D0046928biological_processregulation of neurotransmitter secretion
D0048156molecular_functiontau protein binding
D0048168biological_processregulation of neuronal synaptic plasticity
D0048169biological_processregulation of long-term neuronal synaptic plasticity
D0048471cellular_componentperinuclear region of cytoplasm
D0048488biological_processsynaptic vesicle endocytosis
D0048489biological_processsynaptic vesicle transport
D0050729biological_processpositive regulation of inflammatory response
D0050806biological_processpositive regulation of synaptic transmission
D0050808biological_processsynapse organization
D0050812biological_processregulation of acyl-CoA biosynthetic process
D0051219molecular_functionphosphoprotein binding
D0051259biological_processprotein complex oligomerization
D0051262biological_processprotein tetramerization
D0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
D0051402biological_processneuron apoptotic process
D0051583biological_processdopamine uptake involved in synaptic transmission
D0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
D0051612biological_processnegative regulation of serotonin uptake
D0051621biological_processregulation of norepinephrine uptake
D0051622biological_processnegative regulation of norepinephrine uptake
D0055074biological_processcalcium ion homeostasis
D0060079biological_processexcitatory postsynaptic potential
D0060090molecular_functionmolecular adaptor activity
D0060291biological_processlong-term synaptic potentiation
D0060732biological_processpositive regulation of inositol phosphate biosynthetic process
D0060961molecular_functionphospholipase D inhibitor activity
D0061024biological_processmembrane organization
D0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
D0070555biological_processresponse to interleukin-1
D0070840molecular_functiondynein complex binding
D0071280biological_processcellular response to copper ion
D0071872biological_processcellular response to epinephrine stimulus
D0071902biological_processpositive regulation of protein serine/threonine kinase activity
D0097435biological_processsupramolecular fiber organization
D0098794cellular_componentpostsynapse
D0099512cellular_componentsupramolecular fiber
D1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
D1903136molecular_functioncuprous ion binding
D1903284biological_processpositive regulation of glutathione peroxidase activity
D1903285biological_processpositive regulation of hydrogen peroxide catabolic process
D1903421biological_processregulation of synaptic vesicle recycling
D1903426biological_processregulation of reactive oxygen species biosynthetic process
D1904377biological_processpositive regulation of protein localization to cell periphery
D1904715biological_processnegative regulation of chaperone-mediated autophagy
D1905606biological_processregulation of presynapse assembly
D1990000biological_processamyloid fibril formation
D2000377biological_processregulation of reactive oxygen species metabolic process
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0000149molecular_functionSNARE binding
E0000287molecular_functionmagnesium ion binding
E0000976molecular_functiontranscription cis-regulatory region binding
E0001774biological_processmicroglial cell activation
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Y0005515molecular_functionprotein binding
Y0005543molecular_functionphospholipid binding
Y0005576cellular_componentextracellular region
Y0005615cellular_componentextracellular space
Y0005634cellular_componentnucleus
Y0005737cellular_componentcytoplasm
Y0005739cellular_componentmitochondrion
Y0005764cellular_componentlysosome
Y0005829cellular_componentcytosol
Y0005856cellular_componentcytoskeleton
Y0005886cellular_componentplasma membrane
Y0005938cellular_componentcell cortex
Y0006469biological_processnegative regulation of protein kinase activity
Y0006631biological_processfatty acid metabolic process
Y0006638biological_processneutral lipid metabolic process
Y0006644biological_processphospholipid metabolic process
Y0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
Y0007006biological_processmitochondrial membrane organization
Y0007268biological_processchemical synaptic transmission
Y0007269biological_processneurotransmitter secretion
Y0008198molecular_functionferrous iron binding
Y0008270molecular_functionzinc ion binding
Y0008289molecular_functionlipid binding
Y0008344biological_processadult locomotory behavior
Y0009410biological_processresponse to xenobiotic stimulus
Y0010040biological_processresponse to iron(II) ion
Y0010517biological_processregulation of phospholipase activity
Y0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
Y0014048biological_processregulation of glutamate secretion
Y0014059biological_processregulation of dopamine secretion
Y0015629cellular_componentactin cytoskeleton
Y0016020cellular_componentmembrane
Y0016079biological_processsynaptic vesicle exocytosis
Y0016082biological_processsynaptic vesicle priming
Y0016234cellular_componentinclusion body
Y0016491molecular_functionoxidoreductase activity
Y0019894molecular_functionkinesin binding
Y0022898biological_processregulation of transmembrane transporter activity
Y0030424cellular_componentaxon
Y0030426cellular_componentgrowth cone
Y0030544molecular_functionHsp70 protein binding
Y0030672cellular_componentsynaptic vesicle membrane
Y0031092cellular_componentplatelet alpha granule membrane
Y0031115biological_processnegative regulation of microtubule polymerization
Y0031623biological_processreceptor internalization
Y0031648biological_processprotein destabilization
Y0032026biological_processresponse to magnesium ion
Y0032410biological_processnegative regulation of transporter activity
Y0032496biological_processresponse to lipopolysaccharide
Y0032769biological_processnegative regulation of monooxygenase activity
Y0032991cellular_componentprotein-containing complex
Y0033138biological_processpositive regulation of peptidyl-serine phosphorylation
Y0034341biological_processresponse to type II interferon
Y0034599biological_processcellular response to oxidative stress
Y0035493biological_processSNARE complex assembly
Y0035543biological_processpositive regulation of SNARE complex assembly
Y0040012biological_processregulation of locomotion
Y0042393molecular_functionhistone binding
Y0042416biological_processdopamine biosynthetic process
Y0042417biological_processdopamine metabolic process
Y0042775biological_processmitochondrial ATP synthesis coupled electron transport
Y0042802molecular_functionidentical protein binding
Y0042995cellular_componentcell projection
Y0043014molecular_functionalpha-tubulin binding
Y0043025cellular_componentneuronal cell body
Y0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
Y0043030biological_processregulation of macrophage activation
Y0043065biological_processpositive regulation of apoptotic process
Y0043066biological_processnegative regulation of apoptotic process
Y0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Y0043524biological_processnegative regulation of neuron apoptotic process
Y0043679cellular_componentaxon terminus
Y0045202cellular_componentsynapse
Y0045807biological_processpositive regulation of endocytosis
Y0045920biological_processnegative regulation of exocytosis
Y0045921biological_processpositive regulation of exocytosis
Y0046872molecular_functionmetal ion binding
Y0046928biological_processregulation of neurotransmitter secretion
Y0048156molecular_functiontau protein binding
Y0048168biological_processregulation of neuronal synaptic plasticity
Y0048169biological_processregulation of long-term neuronal synaptic plasticity
Y0048471cellular_componentperinuclear region of cytoplasm
Y0048488biological_processsynaptic vesicle endocytosis
Y0048489biological_processsynaptic vesicle transport
Y0050729biological_processpositive regulation of inflammatory response
Y0050806biological_processpositive regulation of synaptic transmission
Y0050808biological_processsynapse organization
Y0050812biological_processregulation of acyl-CoA biosynthetic process
Y0051219molecular_functionphosphoprotein binding
Y0051259biological_processprotein complex oligomerization
Y0051262biological_processprotein tetramerization
Y0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
Y0051402biological_processneuron apoptotic process
Y0051583biological_processdopamine uptake involved in synaptic transmission
Y0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
Y0051612biological_processnegative regulation of serotonin uptake
Y0051621biological_processregulation of norepinephrine uptake
Y0051622biological_processnegative regulation of norepinephrine uptake
Y0055074biological_processcalcium ion homeostasis
Y0060079biological_processexcitatory postsynaptic potential
Y0060090molecular_functionmolecular adaptor activity
Y0060291biological_processlong-term synaptic potentiation
Y0060732biological_processpositive regulation of inositol phosphate biosynthetic process
Y0060961molecular_functionphospholipase D inhibitor activity
Y0061024biological_processmembrane organization
Y0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
Y0070555biological_processresponse to interleukin-1
Y0070840molecular_functiondynein complex binding
Y0071280biological_processcellular response to copper ion
Y0071872biological_processcellular response to epinephrine stimulus
Y0071902biological_processpositive regulation of protein serine/threonine kinase activity
Y0097435biological_processsupramolecular fiber organization
Y0098794cellular_componentpostsynapse
Y0099512cellular_componentsupramolecular fiber
Y1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
Y1903136molecular_functioncuprous ion binding
Y1903284biological_processpositive regulation of glutathione peroxidase activity
Y1903285biological_processpositive regulation of hydrogen peroxide catabolic process
Y1903421biological_processregulation of synaptic vesicle recycling
Y1903426biological_processregulation of reactive oxygen species biosynthetic process
Y1904377biological_processpositive regulation of protein localization to cell periphery
Y1904715biological_processnegative regulation of chaperone-mediated autophagy
Y1905606biological_processregulation of presynapse assembly
Y1990000biological_processamyloid fibril formation
Y2000377biological_processregulation of reactive oxygen species metabolic process
Z0000122biological_processnegative regulation of transcription by RNA polymerase II
Z0000149molecular_functionSNARE binding
Z0000287molecular_functionmagnesium ion binding
Z0000976molecular_functiontranscription cis-regulatory region binding
Z0001774biological_processmicroglial cell activation
Z0001921biological_processpositive regulation of receptor recycling
Z0001956biological_processpositive regulation of neurotransmitter secretion
Z0001963biological_processsynaptic transmission, dopaminergic
Z0003779molecular_functionactin binding
Z0004860molecular_functionprotein kinase inhibitor activity
Z0005504molecular_functionfatty acid binding
Z0005507molecular_functioncopper ion binding
Z0005509molecular_functioncalcium ion binding
Z0005515molecular_functionprotein binding
Z0005543molecular_functionphospholipid binding
Z0005576cellular_componentextracellular region
Z0005615cellular_componentextracellular space
Z0005634cellular_componentnucleus
Z0005737cellular_componentcytoplasm
Z0005739cellular_componentmitochondrion
Z0005764cellular_componentlysosome
Z0005829cellular_componentcytosol
Z0005856cellular_componentcytoskeleton
Z0005886cellular_componentplasma membrane
Z0005938cellular_componentcell cortex
Z0006469biological_processnegative regulation of protein kinase activity
Z0006631biological_processfatty acid metabolic process
Z0006638biological_processneutral lipid metabolic process
Z0006644biological_processphospholipid metabolic process
Z0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
Z0007006biological_processmitochondrial membrane organization
Z0007268biological_processchemical synaptic transmission
Z0007269biological_processneurotransmitter secretion
Z0008198molecular_functionferrous iron binding
Z0008270molecular_functionzinc ion binding
Z0008289molecular_functionlipid binding
Z0008344biological_processadult locomotory behavior
Z0009410biological_processresponse to xenobiotic stimulus
Z0010040biological_processresponse to iron(II) ion
Z0010517biological_processregulation of phospholipase activity
Z0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
Z0014048biological_processregulation of glutamate secretion
Z0014059biological_processregulation of dopamine secretion
Z0015629cellular_componentactin cytoskeleton
Z0016020cellular_componentmembrane
Z0016079biological_processsynaptic vesicle exocytosis
Z0016082biological_processsynaptic vesicle priming
Z0016234cellular_componentinclusion body
Z0016491molecular_functionoxidoreductase activity
Z0019894molecular_functionkinesin binding
Z0022898biological_processregulation of transmembrane transporter activity
Z0030424cellular_componentaxon
Z0030426cellular_componentgrowth cone
Z0030544molecular_functionHsp70 protein binding
Z0030672cellular_componentsynaptic vesicle membrane
Z0031092cellular_componentplatelet alpha granule membrane
Z0031115biological_processnegative regulation of microtubule polymerization
Z0031623biological_processreceptor internalization
Z0031648biological_processprotein destabilization
Z0032026biological_processresponse to magnesium ion
Z0032410biological_processnegative regulation of transporter activity
Z0032496biological_processresponse to lipopolysaccharide
Z0032769biological_processnegative regulation of monooxygenase activity
Z0032991cellular_componentprotein-containing complex
Z0033138biological_processpositive regulation of peptidyl-serine phosphorylation
Z0034341biological_processresponse to type II interferon
Z0034599biological_processcellular response to oxidative stress
Z0035493biological_processSNARE complex assembly
Z0035543biological_processpositive regulation of SNARE complex assembly
Z0040012biological_processregulation of locomotion
Z0042393molecular_functionhistone binding
Z0042416biological_processdopamine biosynthetic process
Z0042417biological_processdopamine metabolic process
Z0042775biological_processmitochondrial ATP synthesis coupled electron transport
Z0042802molecular_functionidentical protein binding
Z0042995cellular_componentcell projection
Z0043014molecular_functionalpha-tubulin binding
Z0043025cellular_componentneuronal cell body
Z0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
Z0043030biological_processregulation of macrophage activation
Z0043065biological_processpositive regulation of apoptotic process
Z0043066biological_processnegative regulation of apoptotic process
Z0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Z0043524biological_processnegative regulation of neuron apoptotic process
Z0043679cellular_componentaxon terminus
Z0045202cellular_componentsynapse
Z0045807biological_processpositive regulation of endocytosis
Z0045920biological_processnegative regulation of exocytosis
Z0045921biological_processpositive regulation of exocytosis
Z0046872molecular_functionmetal ion binding
Z0046928biological_processregulation of neurotransmitter secretion
Z0048156molecular_functiontau protein binding
Z0048168biological_processregulation of neuronal synaptic plasticity
Z0048169biological_processregulation of long-term neuronal synaptic plasticity
Z0048471cellular_componentperinuclear region of cytoplasm
Z0048488biological_processsynaptic vesicle endocytosis
Z0048489biological_processsynaptic vesicle transport
Z0050729biological_processpositive regulation of inflammatory response
Z0050806biological_processpositive regulation of synaptic transmission
Z0050808biological_processsynapse organization
Z0050812biological_processregulation of acyl-CoA biosynthetic process
Z0051219molecular_functionphosphoprotein binding
Z0051259biological_processprotein complex oligomerization
Z0051262biological_processprotein tetramerization
Z0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
Z0051402biological_processneuron apoptotic process
Z0051583biological_processdopamine uptake involved in synaptic transmission
Z0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
Z0051612biological_processnegative regulation of serotonin uptake
Z0051621biological_processregulation of norepinephrine uptake
Z0051622biological_processnegative regulation of norepinephrine uptake
Z0055074biological_processcalcium ion homeostasis
Z0060079biological_processexcitatory postsynaptic potential
Z0060090molecular_functionmolecular adaptor activity
Z0060291biological_processlong-term synaptic potentiation
Z0060732biological_processpositive regulation of inositol phosphate biosynthetic process
Z0060961molecular_functionphospholipase D inhibitor activity
Z0061024biological_processmembrane organization
Z0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
Z0070555biological_processresponse to interleukin-1
Z0070840molecular_functiondynein complex binding
Z0071280biological_processcellular response to copper ion
Z0071872biological_processcellular response to epinephrine stimulus
Z0071902biological_processpositive regulation of protein serine/threonine kinase activity
Z0097435biological_processsupramolecular fiber organization
Z0098794cellular_componentpostsynapse
Z0099512cellular_componentsupramolecular fiber
Z1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
Z1903136molecular_functioncuprous ion binding
Z1903284biological_processpositive regulation of glutathione peroxidase activity
Z1903285biological_processpositive regulation of hydrogen peroxide catabolic process
Z1903421biological_processregulation of synaptic vesicle recycling
Z1903426biological_processregulation of reactive oxygen species biosynthetic process
Z1904377biological_processpositive regulation of protein localization to cell periphery
Z1904715biological_processnegative regulation of chaperone-mediated autophagy
Z1905606biological_processregulation of presynapse assembly
Z1990000biological_processamyloid fibril formation
Z2000377biological_processregulation of reactive oxygen species metabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
AASP2
EGLN50
WASP2
WGLN50
VASP2
VGLN50
XASP2
XGLN50
YASP2
YGLN50
ZASP2
AGLN50
ZGLN50
BASP2
BGLN50
CASP2
CGLN50
DASP2
DGLN50
EASP2

site_idSWS_FT_FI2
Number of Residues10
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|PubMed:22407793
ChainResidueDetails
AMET1
ZMET1
BMET1
CMET1
DMET1
EMET1
WMET1
VMET1
XMET1
YMET1

site_idSWS_FT_FI3
Number of Residues10
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10617630
ChainResidueDetails
ASER87
ZSER87
BSER87
CSER87
DSER87
ESER87
WSER87
VSER87
XSER87
YSER87

site_idSWS_FT_FI4
Number of Residues10
DetailsMOD_RES: Phosphotyrosine; by FYN => ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:12893833
ChainResidueDetails
ATYR125
ZTYR125
BTYR125
CTYR125
DTYR125
ETYR125
WTYR125
VTYR125
XTYR125
YTYR125

site_idSWS_FT_FI5
Number of Residues10
DetailsMOD_RES: Phosphoserine; by BARK1, PLK2, CK2, CK1 and GRK5 => ECO:0000269|PubMed:10617630, ECO:0000269|PubMed:11813001, ECO:0000269|PubMed:24936070
ChainResidueDetails
ASER129
ZSER129
BSER129
CSER129
DSER129
ESER129
WSER129
VSER129
XSER129
YSER129

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PDB entries from 2024-07-24

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