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6PES

Cryo-EM structure of alpha-synuclein H50Q Wide Fibril

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000149molecular_functionSNARE binding
A0000287molecular_functionmagnesium ion binding
A0000976molecular_functiontranscription cis-regulatory region binding
A0001774biological_processmicroglial cell activation
A0001921biological_processpositive regulation of receptor recycling
A0001963biological_processsynaptic transmission, dopaminergic
A0003779molecular_functionactin binding
A0004857molecular_functionenzyme inhibitor activity
A0004860molecular_functionprotein kinase inhibitor activity
A0004869molecular_functioncysteine-type endopeptidase inhibitor activity
A0005504molecular_functionfatty acid binding
A0005507molecular_functioncopper ion binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005543molecular_functionphospholipid binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005640cellular_componentnuclear outer membrane
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005743cellular_componentmitochondrial inner membrane
A0005759cellular_componentmitochondrial matrix
A0005764cellular_componentlysosome
A0005829cellular_componentcytosol
A0005840cellular_componentribosome
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0006749biological_processglutathione metabolic process
A0008017molecular_functionmicrotubule binding
A0008021cellular_componentsynaptic vesicle
A0008047molecular_functionenzyme activator activity
A0008198molecular_functionferrous iron binding
A0008270molecular_functionzinc ion binding
A0008289molecular_functionlipid binding
A0010040biological_processresponse to iron(II) ion
A0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
A0014059biological_processregulation of dopamine secretion
A0015629cellular_componentactin cytoskeleton
A0015631molecular_functiontubulin binding
A0016020cellular_componentmembrane
A0016079biological_processsynaptic vesicle exocytosis
A0016082biological_processsynaptic vesicle priming
A0016234cellular_componentinclusion body
A0016491molecular_functionoxidoreductase activity
A0019894molecular_functionkinesin binding
A0019899molecular_functionenzyme binding
A0019904molecular_functionprotein domain specific binding
A0030424cellular_componentaxon
A0030426cellular_componentgrowth cone
A0030544molecular_functionHsp70 protein binding
A0030659cellular_componentcytoplasmic vesicle membrane
A0030672cellular_componentsynaptic vesicle membrane
A0031092cellular_componentplatelet alpha granule membrane
A0031115biological_processnegative regulation of microtubule polymerization
A0031623biological_processreceptor internalization
A0031648biological_processprotein destabilization
A0032026biological_processresponse to magnesium ion
A0032496biological_processresponse to lipopolysaccharide
A0032991cellular_componentprotein-containing complex
A0034341biological_processresponse to type II interferon
A0034599biological_processcellular response to oxidative stress
A0035493biological_processSNARE complex assembly
A0035543biological_processpositive regulation of SNARE complex assembly
A0042220biological_processresponse to cocaine
A0042393molecular_functionhistone binding
A0042416biological_processdopamine biosynthetic process
A0042802molecular_functionidentical protein binding
A0043014molecular_functionalpha-tubulin binding
A0043025cellular_componentneuronal cell body
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043195cellular_componentterminal bouton
A0043274molecular_functionphospholipase binding
A0043524biological_processnegative regulation of neuron apoptotic process
A0043679cellular_componentaxon terminus
A0044344biological_processcellular response to fibroblast growth factor stimulus
A0045202cellular_componentsynapse
A0045807biological_processpositive regulation of endocytosis
A0045920biological_processnegative regulation of exocytosis
A0045921biological_processpositive regulation of exocytosis
A0045963biological_processnegative regulation of dopamine metabolic process
A0046872molecular_functionmetal ion binding
A0048148biological_processbehavioral response to cocaine
A0048156molecular_functiontau protein binding
A0048471cellular_componentperinuclear region of cytoplasm
A0048487molecular_functionbeta-tubulin binding
A0048488biological_processsynaptic vesicle endocytosis
A0048489biological_processsynaptic vesicle transport
A0050729biological_processpositive regulation of inflammatory response
A0050808biological_processsynapse organization
A0051219molecular_functionphosphoprotein binding
A0051259biological_processprotein complex oligomerization
A0051262biological_processprotein tetramerization
A0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
A0051583biological_processdopamine uptake involved in synaptic transmission
A0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
A0051612biological_processnegative regulation of serotonin uptake
A0051621biological_processregulation of norepinephrine uptake
A0051622biological_processnegative regulation of norepinephrine uptake
A0055074biological_processcalcium ion homeostasis
A0060732biological_processpositive regulation of inositol phosphate biosynthetic process
A0060961molecular_functionphospholipase D inhibitor activity
A0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
A0070507biological_processregulation of microtubule cytoskeleton organization
A0070555biological_processresponse to interleukin-1
A0070840molecular_functiondynein complex binding
A0071280biological_processcellular response to copper ion
A0071872biological_processcellular response to epinephrine stimulus
A0097413cellular_componentLewy body
A0097435biological_processsupramolecular fiber organization
A0098793cellular_componentpresynapse
A0099512cellular_componentsupramolecular fiber
A0140311molecular_functionprotein sequestering activity
A0141108molecular_functiontransporter regulator activity
A1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
A1903136molecular_functioncuprous ion binding
A1903285biological_processpositive regulation of hydrogen peroxide catabolic process
A1903421biological_processregulation of synaptic vesicle recycling
A1903426biological_processregulation of reactive oxygen species biosynthetic process
A1904307biological_processresponse to desipramine
A1904377biological_processpositive regulation of protein localization to cell periphery
A1904715biological_processnegative regulation of chaperone-mediated autophagy
A1905606biological_processregulation of presynapse assembly
A1990000biological_processamyloid fibril formation
A2000377biological_processregulation of reactive oxygen species metabolic process
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000149molecular_functionSNARE binding
B0000287molecular_functionmagnesium ion binding
B0000976molecular_functiontranscription cis-regulatory region binding
B0001774biological_processmicroglial cell activation
B0001921biological_processpositive regulation of receptor recycling
B0001963biological_processsynaptic transmission, dopaminergic
B0003779molecular_functionactin binding
B0004857molecular_functionenzyme inhibitor activity
B0004860molecular_functionprotein kinase inhibitor activity
B0004869molecular_functioncysteine-type endopeptidase inhibitor activity
B0005504molecular_functionfatty acid binding
B0005507molecular_functioncopper ion binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005543molecular_functionphospholipid binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005640cellular_componentnuclear outer membrane
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005741cellular_componentmitochondrial outer membrane
B0005743cellular_componentmitochondrial inner membrane
B0005759cellular_componentmitochondrial matrix
B0005764cellular_componentlysosome
B0005829cellular_componentcytosol
B0005840cellular_componentribosome
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005938cellular_componentcell cortex
B0006749biological_processglutathione metabolic process
B0008017molecular_functionmicrotubule binding
B0008021cellular_componentsynaptic vesicle
B0008047molecular_functionenzyme activator activity
B0008198molecular_functionferrous iron binding
B0008270molecular_functionzinc ion binding
B0008289molecular_functionlipid binding
B0010040biological_processresponse to iron(II) ion
B0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
B0014059biological_processregulation of dopamine secretion
B0015629cellular_componentactin cytoskeleton
B0015631molecular_functiontubulin binding
B0016020cellular_componentmembrane
B0016079biological_processsynaptic vesicle exocytosis
B0016082biological_processsynaptic vesicle priming
B0016234cellular_componentinclusion body
B0016491molecular_functionoxidoreductase activity
B0019894molecular_functionkinesin binding
B0019899molecular_functionenzyme binding
B0019904molecular_functionprotein domain specific binding
B0030424cellular_componentaxon
B0030426cellular_componentgrowth cone
B0030544molecular_functionHsp70 protein binding
B0030659cellular_componentcytoplasmic vesicle membrane
B0030672cellular_componentsynaptic vesicle membrane
B0031092cellular_componentplatelet alpha granule membrane
B0031115biological_processnegative regulation of microtubule polymerization
B0031623biological_processreceptor internalization
B0031648biological_processprotein destabilization
B0032026biological_processresponse to magnesium ion
B0032496biological_processresponse to lipopolysaccharide
B0032991cellular_componentprotein-containing complex
B0034341biological_processresponse to type II interferon
B0034599biological_processcellular response to oxidative stress
B0035493biological_processSNARE complex assembly
B0035543biological_processpositive regulation of SNARE complex assembly
B0042220biological_processresponse to cocaine
B0042393molecular_functionhistone binding
B0042416biological_processdopamine biosynthetic process
B0042802molecular_functionidentical protein binding
B0043014molecular_functionalpha-tubulin binding
B0043025cellular_componentneuronal cell body
B0043065biological_processpositive regulation of apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0043195cellular_componentterminal bouton
B0043274molecular_functionphospholipase binding
B0043524biological_processnegative regulation of neuron apoptotic process
B0043679cellular_componentaxon terminus
B0044344biological_processcellular response to fibroblast growth factor stimulus
B0045202cellular_componentsynapse
B0045807biological_processpositive regulation of endocytosis
B0045920biological_processnegative regulation of exocytosis
B0045921biological_processpositive regulation of exocytosis
B0045963biological_processnegative regulation of dopamine metabolic process
B0046872molecular_functionmetal ion binding
B0048148biological_processbehavioral response to cocaine
B0048156molecular_functiontau protein binding
B0048471cellular_componentperinuclear region of cytoplasm
B0048487molecular_functionbeta-tubulin binding
B0048488biological_processsynaptic vesicle endocytosis
B0048489biological_processsynaptic vesicle transport
B0050729biological_processpositive regulation of inflammatory response
B0050808biological_processsynapse organization
B0051219molecular_functionphosphoprotein binding
B0051259biological_processprotein complex oligomerization
B0051262biological_processprotein tetramerization
B0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
B0051583biological_processdopamine uptake involved in synaptic transmission
B0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
B0051612biological_processnegative regulation of serotonin uptake
B0051621biological_processregulation of norepinephrine uptake
B0051622biological_processnegative regulation of norepinephrine uptake
B0055074biological_processcalcium ion homeostasis
B0060732biological_processpositive regulation of inositol phosphate biosynthetic process
B0060961molecular_functionphospholipase D inhibitor activity
B0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
B0070507biological_processregulation of microtubule cytoskeleton organization
B0070555biological_processresponse to interleukin-1
B0070840molecular_functiondynein complex binding
B0071280biological_processcellular response to copper ion
B0071872biological_processcellular response to epinephrine stimulus
B0097413cellular_componentLewy body
B0097435biological_processsupramolecular fiber organization
B0098793cellular_componentpresynapse
B0099512cellular_componentsupramolecular fiber
B0140311molecular_functionprotein sequestering activity
B0141108molecular_functiontransporter regulator activity
B1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
B1903136molecular_functioncuprous ion binding
B1903285biological_processpositive regulation of hydrogen peroxide catabolic process
B1903421biological_processregulation of synaptic vesicle recycling
B1903426biological_processregulation of reactive oxygen species biosynthetic process
B1904307biological_processresponse to desipramine
B1904377biological_processpositive regulation of protein localization to cell periphery
B1904715biological_processnegative regulation of chaperone-mediated autophagy
B1905606biological_processregulation of presynapse assembly
B1990000biological_processamyloid fibril formation
B2000377biological_processregulation of reactive oxygen species metabolic process
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000149molecular_functionSNARE binding
C0000287molecular_functionmagnesium ion binding
C0000976molecular_functiontranscription cis-regulatory region binding
C0001774biological_processmicroglial cell activation
C0001921biological_processpositive regulation of receptor recycling
C0001963biological_processsynaptic transmission, dopaminergic
C0003779molecular_functionactin binding
C0004857molecular_functionenzyme inhibitor activity
C0004860molecular_functionprotein kinase inhibitor activity
C0004869molecular_functioncysteine-type endopeptidase inhibitor activity
C0005504molecular_functionfatty acid binding
C0005507molecular_functioncopper ion binding
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005543molecular_functionphospholipid binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005640cellular_componentnuclear outer membrane
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005741cellular_componentmitochondrial outer membrane
C0005743cellular_componentmitochondrial inner membrane
C0005759cellular_componentmitochondrial matrix
C0005764cellular_componentlysosome
C0005829cellular_componentcytosol
C0005840cellular_componentribosome
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0005938cellular_componentcell cortex
C0006749biological_processglutathione metabolic process
C0008017molecular_functionmicrotubule binding
C0008021cellular_componentsynaptic vesicle
C0008047molecular_functionenzyme activator activity
C0008198molecular_functionferrous iron binding
C0008270molecular_functionzinc ion binding
C0008289molecular_functionlipid binding
C0010040biological_processresponse to iron(II) ion
C0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
C0014059biological_processregulation of dopamine secretion
C0015629cellular_componentactin cytoskeleton
C0015631molecular_functiontubulin binding
C0016020cellular_componentmembrane
C0016079biological_processsynaptic vesicle exocytosis
C0016082biological_processsynaptic vesicle priming
C0016234cellular_componentinclusion body
C0016491molecular_functionoxidoreductase activity
C0019894molecular_functionkinesin binding
C0019899molecular_functionenzyme binding
C0019904molecular_functionprotein domain specific binding
C0030424cellular_componentaxon
C0030426cellular_componentgrowth cone
C0030544molecular_functionHsp70 protein binding
C0030659cellular_componentcytoplasmic vesicle membrane
C0030672cellular_componentsynaptic vesicle membrane
C0031092cellular_componentplatelet alpha granule membrane
C0031115biological_processnegative regulation of microtubule polymerization
C0031623biological_processreceptor internalization
C0031648biological_processprotein destabilization
C0032026biological_processresponse to magnesium ion
C0032496biological_processresponse to lipopolysaccharide
C0032991cellular_componentprotein-containing complex
C0034341biological_processresponse to type II interferon
C0034599biological_processcellular response to oxidative stress
C0035493biological_processSNARE complex assembly
C0035543biological_processpositive regulation of SNARE complex assembly
C0042220biological_processresponse to cocaine
C0042393molecular_functionhistone binding
C0042416biological_processdopamine biosynthetic process
C0042802molecular_functionidentical protein binding
C0043014molecular_functionalpha-tubulin binding
C0043025cellular_componentneuronal cell body
C0043065biological_processpositive regulation of apoptotic process
C0043066biological_processnegative regulation of apoptotic process
C0043195cellular_componentterminal bouton
C0043274molecular_functionphospholipase binding
C0043524biological_processnegative regulation of neuron apoptotic process
C0043679cellular_componentaxon terminus
C0044344biological_processcellular response to fibroblast growth factor stimulus
C0045202cellular_componentsynapse
C0045807biological_processpositive regulation of endocytosis
C0045920biological_processnegative regulation of exocytosis
C0045921biological_processpositive regulation of exocytosis
C0045963biological_processnegative regulation of dopamine metabolic process
C0046872molecular_functionmetal ion binding
C0048148biological_processbehavioral response to cocaine
C0048156molecular_functiontau protein binding
C0048471cellular_componentperinuclear region of cytoplasm
C0048487molecular_functionbeta-tubulin binding
C0048488biological_processsynaptic vesicle endocytosis
C0048489biological_processsynaptic vesicle transport
C0050729biological_processpositive regulation of inflammatory response
C0050808biological_processsynapse organization
C0051219molecular_functionphosphoprotein binding
C0051259biological_processprotein complex oligomerization
C0051262biological_processprotein tetramerization
C0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
C0051583biological_processdopamine uptake involved in synaptic transmission
C0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
C0051612biological_processnegative regulation of serotonin uptake
C0051621biological_processregulation of norepinephrine uptake
C0051622biological_processnegative regulation of norepinephrine uptake
C0055074biological_processcalcium ion homeostasis
C0060732biological_processpositive regulation of inositol phosphate biosynthetic process
C0060961molecular_functionphospholipase D inhibitor activity
C0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
C0070507biological_processregulation of microtubule cytoskeleton organization
C0070555biological_processresponse to interleukin-1
C0070840molecular_functiondynein complex binding
C0071280biological_processcellular response to copper ion
C0071872biological_processcellular response to epinephrine stimulus
C0097413cellular_componentLewy body
C0097435biological_processsupramolecular fiber organization
C0098793cellular_componentpresynapse
C0099512cellular_componentsupramolecular fiber
C0140311molecular_functionprotein sequestering activity
C0141108molecular_functiontransporter regulator activity
C1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
C1903136molecular_functioncuprous ion binding
C1903285biological_processpositive regulation of hydrogen peroxide catabolic process
C1903421biological_processregulation of synaptic vesicle recycling
C1903426biological_processregulation of reactive oxygen species biosynthetic process
C1904307biological_processresponse to desipramine
C1904377biological_processpositive regulation of protein localization to cell periphery
C1904715biological_processnegative regulation of chaperone-mediated autophagy
C1905606biological_processregulation of presynapse assembly
C1990000biological_processamyloid fibril formation
C2000377biological_processregulation of reactive oxygen species metabolic process
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000149molecular_functionSNARE binding
D0000287molecular_functionmagnesium ion binding
D0000976molecular_functiontranscription cis-regulatory region binding
D0001774biological_processmicroglial cell activation
D0001921biological_processpositive regulation of receptor recycling
D0001963biological_processsynaptic transmission, dopaminergic
D0003779molecular_functionactin binding
D0004857molecular_functionenzyme inhibitor activity
D0004860molecular_functionprotein kinase inhibitor activity
D0004869molecular_functioncysteine-type endopeptidase inhibitor activity
D0005504molecular_functionfatty acid binding
D0005507molecular_functioncopper ion binding
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005543molecular_functionphospholipid binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005640cellular_componentnuclear outer membrane
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005741cellular_componentmitochondrial outer membrane
D0005743cellular_componentmitochondrial inner membrane
D0005759cellular_componentmitochondrial matrix
D0005764cellular_componentlysosome
D0005829cellular_componentcytosol
D0005840cellular_componentribosome
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0005938cellular_componentcell cortex
D0006749biological_processglutathione metabolic process
D0008017molecular_functionmicrotubule binding
D0008021cellular_componentsynaptic vesicle
D0008047molecular_functionenzyme activator activity
D0008198molecular_functionferrous iron binding
D0008270molecular_functionzinc ion binding
D0008289molecular_functionlipid binding
D0010040biological_processresponse to iron(II) ion
D0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
D0014059biological_processregulation of dopamine secretion
D0015629cellular_componentactin cytoskeleton
D0015631molecular_functiontubulin binding
D0016020cellular_componentmembrane
D0016079biological_processsynaptic vesicle exocytosis
D0016082biological_processsynaptic vesicle priming
D0016234cellular_componentinclusion body
D0016491molecular_functionoxidoreductase activity
D0019894molecular_functionkinesin binding
D0019899molecular_functionenzyme binding
D0019904molecular_functionprotein domain specific binding
D0030424cellular_componentaxon
D0030426cellular_componentgrowth cone
D0030544molecular_functionHsp70 protein binding
D0030659cellular_componentcytoplasmic vesicle membrane
D0030672cellular_componentsynaptic vesicle membrane
D0031092cellular_componentplatelet alpha granule membrane
D0031115biological_processnegative regulation of microtubule polymerization
D0031623biological_processreceptor internalization
D0031648biological_processprotein destabilization
D0032026biological_processresponse to magnesium ion
D0032496biological_processresponse to lipopolysaccharide
D0032991cellular_componentprotein-containing complex
D0034341biological_processresponse to type II interferon
D0034599biological_processcellular response to oxidative stress
D0035493biological_processSNARE complex assembly
D0035543biological_processpositive regulation of SNARE complex assembly
D0042220biological_processresponse to cocaine
D0042393molecular_functionhistone binding
D0042416biological_processdopamine biosynthetic process
D0042802molecular_functionidentical protein binding
D0043014molecular_functionalpha-tubulin binding
D0043025cellular_componentneuronal cell body
D0043065biological_processpositive regulation of apoptotic process
D0043066biological_processnegative regulation of apoptotic process
D0043195cellular_componentterminal bouton
D0043274molecular_functionphospholipase binding
D0043524biological_processnegative regulation of neuron apoptotic process
D0043679cellular_componentaxon terminus
D0044344biological_processcellular response to fibroblast growth factor stimulus
D0045202cellular_componentsynapse
D0045807biological_processpositive regulation of endocytosis
D0045920biological_processnegative regulation of exocytosis
D0045921biological_processpositive regulation of exocytosis
D0045963biological_processnegative regulation of dopamine metabolic process
D0046872molecular_functionmetal ion binding
D0048148biological_processbehavioral response to cocaine
D0048156molecular_functiontau protein binding
D0048471cellular_componentperinuclear region of cytoplasm
D0048487molecular_functionbeta-tubulin binding
D0048488biological_processsynaptic vesicle endocytosis
D0048489biological_processsynaptic vesicle transport
D0050729biological_processpositive regulation of inflammatory response
D0050808biological_processsynapse organization
D0051219molecular_functionphosphoprotein binding
D0051259biological_processprotein complex oligomerization
D0051262biological_processprotein tetramerization
D0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
D0051583biological_processdopamine uptake involved in synaptic transmission
D0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
D0051612biological_processnegative regulation of serotonin uptake
D0051621biological_processregulation of norepinephrine uptake
D0051622biological_processnegative regulation of norepinephrine uptake
D0055074biological_processcalcium ion homeostasis
D0060732biological_processpositive regulation of inositol phosphate biosynthetic process
D0060961molecular_functionphospholipase D inhibitor activity
D0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
D0070507biological_processregulation of microtubule cytoskeleton organization
D0070555biological_processresponse to interleukin-1
D0070840molecular_functiondynein complex binding
D0071280biological_processcellular response to copper ion
D0071872biological_processcellular response to epinephrine stimulus
D0097413cellular_componentLewy body
D0097435biological_processsupramolecular fiber organization
D0098793cellular_componentpresynapse
D0099512cellular_componentsupramolecular fiber
D0140311molecular_functionprotein sequestering activity
D0141108molecular_functiontransporter regulator activity
D1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
D1903136molecular_functioncuprous ion binding
D1903285biological_processpositive regulation of hydrogen peroxide catabolic process
D1903421biological_processregulation of synaptic vesicle recycling
D1903426biological_processregulation of reactive oxygen species biosynthetic process
D1904307biological_processresponse to desipramine
D1904377biological_processpositive regulation of protein localization to cell periphery
D1904715biological_processnegative regulation of chaperone-mediated autophagy
D1905606biological_processregulation of presynapse assembly
D1990000biological_processamyloid fibril formation
D2000377biological_processregulation of reactive oxygen species metabolic process
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0000149molecular_functionSNARE binding
E0000287molecular_functionmagnesium ion binding
E0000976molecular_functiontranscription cis-regulatory region binding
E0001774biological_processmicroglial cell activation
E0001921biological_processpositive regulation of receptor recycling
E0001963biological_processsynaptic transmission, dopaminergic
E0003779molecular_functionactin binding
E0004857molecular_functionenzyme inhibitor activity
E0004860molecular_functionprotein kinase inhibitor activity
E0004869molecular_functioncysteine-type endopeptidase inhibitor activity
E0005504molecular_functionfatty acid binding
E0005507molecular_functioncopper ion binding
E0005509molecular_functioncalcium ion binding
E0005515molecular_functionprotein binding
E0005543molecular_functionphospholipid binding
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0005634cellular_componentnucleus
E0005640cellular_componentnuclear outer membrane
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005741cellular_componentmitochondrial outer membrane
E0005743cellular_componentmitochondrial inner membrane
E0005759cellular_componentmitochondrial matrix
E0005764cellular_componentlysosome
E0005829cellular_componentcytosol
E0005840cellular_componentribosome
E0005856cellular_componentcytoskeleton
E0005886cellular_componentplasma membrane
E0005938cellular_componentcell cortex
E0006749biological_processglutathione metabolic process
E0008017molecular_functionmicrotubule binding
E0008021cellular_componentsynaptic vesicle
E0008047molecular_functionenzyme activator activity
E0008198molecular_functionferrous iron binding
E0008270molecular_functionzinc ion binding
E0008289molecular_functionlipid binding
E0010040biological_processresponse to iron(II) ion
E0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
E0014059biological_processregulation of dopamine secretion
E0015629cellular_componentactin cytoskeleton
E0015631molecular_functiontubulin binding
E0016020cellular_componentmembrane
E0016079biological_processsynaptic vesicle exocytosis
E0016082biological_processsynaptic vesicle priming
E0016234cellular_componentinclusion body
E0016491molecular_functionoxidoreductase activity
E0019894molecular_functionkinesin binding
E0019899molecular_functionenzyme binding
E0019904molecular_functionprotein domain specific binding
E0030424cellular_componentaxon
E0030426cellular_componentgrowth cone
E0030544molecular_functionHsp70 protein binding
E0030659cellular_componentcytoplasmic vesicle membrane
E0030672cellular_componentsynaptic vesicle membrane
E0031092cellular_componentplatelet alpha granule membrane
E0031115biological_processnegative regulation of microtubule polymerization
E0031623biological_processreceptor internalization
E0031648biological_processprotein destabilization
E0032026biological_processresponse to magnesium ion
E0032496biological_processresponse to lipopolysaccharide
E0032991cellular_componentprotein-containing complex
E0034341biological_processresponse to type II interferon
E0034599biological_processcellular response to oxidative stress
E0035493biological_processSNARE complex assembly
E0035543biological_processpositive regulation of SNARE complex assembly
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Y2000377biological_processregulation of reactive oxygen species metabolic process
Z0000122biological_processnegative regulation of transcription by RNA polymerase II
Z0000149molecular_functionSNARE binding
Z0000287molecular_functionmagnesium ion binding
Z0000976molecular_functiontranscription cis-regulatory region binding
Z0001774biological_processmicroglial cell activation
Z0001921biological_processpositive regulation of receptor recycling
Z0001963biological_processsynaptic transmission, dopaminergic
Z0003779molecular_functionactin binding
Z0004857molecular_functionenzyme inhibitor activity
Z0004860molecular_functionprotein kinase inhibitor activity
Z0004869molecular_functioncysteine-type endopeptidase inhibitor activity
Z0005504molecular_functionfatty acid binding
Z0005507molecular_functioncopper ion binding
Z0005509molecular_functioncalcium ion binding
Z0005515molecular_functionprotein binding
Z0005543molecular_functionphospholipid binding
Z0005576cellular_componentextracellular region
Z0005615cellular_componentextracellular space
Z0005634cellular_componentnucleus
Z0005640cellular_componentnuclear outer membrane
Z0005737cellular_componentcytoplasm
Z0005739cellular_componentmitochondrion
Z0005741cellular_componentmitochondrial outer membrane
Z0005743cellular_componentmitochondrial inner membrane
Z0005759cellular_componentmitochondrial matrix
Z0005764cellular_componentlysosome
Z0005829cellular_componentcytosol
Z0005840cellular_componentribosome
Z0005856cellular_componentcytoskeleton
Z0005886cellular_componentplasma membrane
Z0005938cellular_componentcell cortex
Z0006749biological_processglutathione metabolic process
Z0008017molecular_functionmicrotubule binding
Z0008021cellular_componentsynaptic vesicle
Z0008047molecular_functionenzyme activator activity
Z0008198molecular_functionferrous iron binding
Z0008270molecular_functionzinc ion binding
Z0008289molecular_functionlipid binding
Z0010040biological_processresponse to iron(II) ion
Z0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
Z0014059biological_processregulation of dopamine secretion
Z0015629cellular_componentactin cytoskeleton
Z0015631molecular_functiontubulin binding
Z0016020cellular_componentmembrane
Z0016079biological_processsynaptic vesicle exocytosis
Z0016082biological_processsynaptic vesicle priming
Z0016234cellular_componentinclusion body
Z0016491molecular_functionoxidoreductase activity
Z0019894molecular_functionkinesin binding
Z0019899molecular_functionenzyme binding
Z0019904molecular_functionprotein domain specific binding
Z0030424cellular_componentaxon
Z0030426cellular_componentgrowth cone
Z0030544molecular_functionHsp70 protein binding
Z0030659cellular_componentcytoplasmic vesicle membrane
Z0030672cellular_componentsynaptic vesicle membrane
Z0031092cellular_componentplatelet alpha granule membrane
Z0031115biological_processnegative regulation of microtubule polymerization
Z0031623biological_processreceptor internalization
Z0031648biological_processprotein destabilization
Z0032026biological_processresponse to magnesium ion
Z0032496biological_processresponse to lipopolysaccharide
Z0032991cellular_componentprotein-containing complex
Z0034341biological_processresponse to type II interferon
Z0034599biological_processcellular response to oxidative stress
Z0035493biological_processSNARE complex assembly
Z0035543biological_processpositive regulation of SNARE complex assembly
Z0042220biological_processresponse to cocaine
Z0042393molecular_functionhistone binding
Z0042416biological_processdopamine biosynthetic process
Z0042802molecular_functionidentical protein binding
Z0043014molecular_functionalpha-tubulin binding
Z0043025cellular_componentneuronal cell body
Z0043065biological_processpositive regulation of apoptotic process
Z0043066biological_processnegative regulation of apoptotic process
Z0043195cellular_componentterminal bouton
Z0043274molecular_functionphospholipase binding
Z0043524biological_processnegative regulation of neuron apoptotic process
Z0043679cellular_componentaxon terminus
Z0044344biological_processcellular response to fibroblast growth factor stimulus
Z0045202cellular_componentsynapse
Z0045807biological_processpositive regulation of endocytosis
Z0045920biological_processnegative regulation of exocytosis
Z0045921biological_processpositive regulation of exocytosis
Z0045963biological_processnegative regulation of dopamine metabolic process
Z0046872molecular_functionmetal ion binding
Z0048148biological_processbehavioral response to cocaine
Z0048156molecular_functiontau protein binding
Z0048471cellular_componentperinuclear region of cytoplasm
Z0048487molecular_functionbeta-tubulin binding
Z0048488biological_processsynaptic vesicle endocytosis
Z0048489biological_processsynaptic vesicle transport
Z0050729biological_processpositive regulation of inflammatory response
Z0050808biological_processsynapse organization
Z0051219molecular_functionphosphoprotein binding
Z0051259biological_processprotein complex oligomerization
Z0051262biological_processprotein tetramerization
Z0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
Z0051583biological_processdopamine uptake involved in synaptic transmission
Z0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
Z0051612biological_processnegative regulation of serotonin uptake
Z0051621biological_processregulation of norepinephrine uptake
Z0051622biological_processnegative regulation of norepinephrine uptake
Z0055074biological_processcalcium ion homeostasis
Z0060732biological_processpositive regulation of inositol phosphate biosynthetic process
Z0060961molecular_functionphospholipase D inhibitor activity
Z0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
Z0070507biological_processregulation of microtubule cytoskeleton organization
Z0070555biological_processresponse to interleukin-1
Z0070840molecular_functiondynein complex binding
Z0071280biological_processcellular response to copper ion
Z0071872biological_processcellular response to epinephrine stimulus
Z0097413cellular_componentLewy body
Z0097435biological_processsupramolecular fiber organization
Z0098793cellular_componentpresynapse
Z0099512cellular_componentsupramolecular fiber
Z0140311molecular_functionprotein sequestering activity
Z0141108molecular_functiontransporter regulator activity
Z1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
Z1903136molecular_functioncuprous ion binding
Z1903285biological_processpositive regulation of hydrogen peroxide catabolic process
Z1903421biological_processregulation of synaptic vesicle recycling
Z1903426biological_processregulation of reactive oxygen species biosynthetic process
Z1904307biological_processresponse to desipramine
Z1904377biological_processpositive regulation of protein localization to cell periphery
Z1904715biological_processnegative regulation of chaperone-mediated autophagy
Z1905606biological_processregulation of presynapse assembly
Z1990000biological_processamyloid fibril formation
Z2000377biological_processregulation of reactive oxygen species metabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues70
DetailsRepeat: {"description":"3; approximate"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues100
DetailsRepeat: {"description":"4"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues10
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues10
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"10617630","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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