6PEN

Structure of Spastin Hexamer (whole model) in complex with substrate peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0008568	molecular_function	microtubule severing ATPase activity
A	0016887	molecular_function	ATP hydrolysis activity
B	0005524	molecular_function	ATP binding
B	0008568	molecular_function	microtubule severing ATPase activity
B	0016887	molecular_function	ATP hydrolysis activity
C	0005524	molecular_function	ATP binding
C	0008568	molecular_function	microtubule severing ATPase activity
C	0016887	molecular_function	ATP hydrolysis activity
D	0005524	molecular_function	ATP binding
D	0008568	molecular_function	microtubule severing ATPase activity
D	0016887	molecular_function	ATP hydrolysis activity
E	0005524	molecular_function	ATP binding
E	0008568	molecular_function	microtubule severing ATPase activity
E	0016887	molecular_function	ATP hydrolysis activity
F	0005524	molecular_function	ATP binding
F	0008568	molecular_function	microtubule severing ATPase activity
F	0016887	molecular_function	ATP hydrolysis activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue ADP A 701

Chain	Residue
A	ALA345
A	SER547
A	THR550
A	BEF702
A	MG703
B	ARG498
A	GLY385
A	ASN386
A	GLY387
A	LYS388
A	THR389
A	MET390
A	LEU517
A	GLY546

---

site_id	AC2
Number of Residues	8
Details	binding site for residue BEF A 702

Chain	Residue
A	PRO384
A	GLY385
A	LYS388
A	ASN487
A	ADP701
A	MG703
B	ARG498
B	ARG499

---

site_id	AC3
Number of Residues	4
Details	binding site for residue MG A 703

Chain	Residue
A	THR389
A	ASP441
A	ADP701
A	BEF702

---

site_id	AC4
Number of Residues	13
Details	binding site for residue ADP B 701

Chain	Residue
B	ALA345
B	GLY385
B	ASN386
B	GLY387
B	THR389
B	MET390
B	LEU517
B	GLY546
B	SER547
B	BEF702
B	MG703
C	ASP470
C	ARG498

---

site_id	AC5
Number of Residues	8
Details	binding site for residue BEF B 702

Chain	Residue
B	PRO384
B	GLY385
B	LYS388
B	ASN487
B	ADP701
B	MG703
C	ARG498
C	ARG499

---

site_id	AC6
Number of Residues	4
Details	binding site for residue MG B 703

Chain	Residue
B	THR389
B	ASP441
B	ADP701
B	BEF702

---

site_id	AC7
Number of Residues	16
Details	binding site for residue ADP C 701

Chain	Residue
C	ASP343
C	ALA345
C	GLY385
C	ASN386
C	GLY387
C	LYS388
C	THR389
C	MET390
C	LEU517
C	GLY546
C	SER547
C	THR550
C	BEF702
C	MG703
D	ASP470
D	ARG498

---

site_id	AC8
Number of Residues	9
Details	binding site for residue BEF C 702

Chain	Residue
C	PRO383
C	PRO384
C	GLY385
C	ASN386
C	LYS388
C	ADP701
C	MG703
D	ARG498
D	ARG499

---

site_id	AC9
Number of Residues	4
Details	binding site for residue MG C 703

Chain	Residue
C	THR389
C	ASP441
C	ADP701
C	BEF702

---

site_id	AD1
Number of Residues	11
Details	binding site for residue ADP D 701

Chain	Residue
D	ASP343
D	ALA345
D	GLY385
D	ASN386
D	GLY387
D	LYS388
D	THR389
D	MET390
D	GLY546
D	BEF702
D	MG703

---

site_id	AD2
Number of Residues	8
Details	binding site for residue BEF D 702

Chain	Residue
D	PRO384
D	GLY385
D	LYS388
D	ASN487
D	ADP701
D	MG703
E	ARG498
E	ARG499

---

site_id	AD3
Number of Residues	3
Details	binding site for residue MG D 703

Chain	Residue
D	THR389
D	ADP701
D	BEF702

---

site_id	AD4
Number of Residues	10
Details	binding site for residue ADP E 701

Chain	Residue
E	ILE344
E	PRO384
E	GLY385
E	ASN386
E	GLY387
E	LYS388
E	THR389
E	MET390
E	LEU517
E	GLY546

---

Functional Information from PROSITE/UniProt

site_id	PS00674
Number of Residues	20
Details	AAA AAA-protein family signature. VlVMgATNrpqeLDeAVlrR

Chain	Residue	Details
A	VAL480-ARG499

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000305|PubMed:15716377

Chain	Residue	Details
A	LYS414
B	LYS414
C	LYS414
D	LYS414
E	LYS414
F	LYS414

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	GLY277
B	GLY277
C	GLY277
D	GLY277
E	GLY277
F	GLY277

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	LYS300
B	LYS300
C	LYS300
D	LYS300
E	LYS300
F	LYS300

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	ALA338
B	ALA338
C	ALA338
D	ALA338
E	ALA338
F	ALA338

---